11,520 research outputs found
Completion of Mitosis Requires Neither fzr/rap nor fzr2, a Male Germline-Specific Drosophila Cdh1 Homolog
AbstractProteolysis of mitotic regulators like securins and cyclins requires Fizzy(FZY)/Cdc20 and Fizzy-related(FZR)/Hct1/Cdh1 proteins [1–5]. Budding yeast Cdh1 acts not only during G1, but is also required for B-type cyclin degradation during exit from mitosis when Cdh1 is a target of the mitotic exit network controlling progression through late mitosis and cytokinesis [6, 7]. In contrast, observations in frog and Drosophila embryos have suggested that the orthologous FZR is not involved during exit from mitosis [3, 8]. However, the potential involvement of minor amounts of maternally derived FZR was not excluded in these studies. Similarly, the reported absence of severe mitotic defects in chicken Cdh1−/− cells [9] might be explained by the recent identification of multiple Cdh1 genes [10]. Here, we have carefully analyzed the FZR requirement during exit from mitosis in Drosophila, which, apart from fzr, has only one additional homolog. We find that this fzr2 gene, although expressed in the male germline, is not expressed during mitotic divisions. Moreover, by characterizing fzr alleles, we demonstrate that completion of mitosis including Cyclin B degradation does not require FZR. However, fzr is an essential gene corresponding to the rap locus, and FZR, which accumulates predominantly in the cytoplasm, is clearly required during G1
A Straightforward Introduction to Continuous Quantum Measurement
We present a pedagogical treatment of the formalism of continuous quantum
measurement. Our aim is to show the reader how the equations describing such
measurements are derived and manipulated in a direct manner. We also give
elementary background material for those new to measurement theory, and
describe further various aspects of continuous measurements that should be
helpful to those wanting to use such measurements in applications.
Specifically, we use the simple and direct approach of generalized measurements
to derive the stochastic master equation describing the continuous measurements
of observables, give a tutorial on stochastic calculus, treat multiple
observers and inefficient detection, examine a general form of the measurement
master equation, and show how the master equation leads to information gain and
disturbance. To conclude, we give a detailed treatment of imaging the resonance
fluorescence from a single atom as a concrete example of how a continuous
position measurement arises in a physical system.Comment: 24 pages, 3 eps figues. To appear in Contemporary Physic
Optimal control of entanglement via quantum feedback
It has recently been shown that finding the optimal measurement on the
environment for stationary Linear Quadratic Gaussian control problems is a
semi-definite program. We apply this technique to the control of the
EPR-correlations between two bosonic modes interacting via a parametric
Hamiltonian at steady state. The optimal measurement turns out to be nonlocal
homodyne measurement -- the outputs of the two modes must be combined before
measurement. We also find the optimal local measurement and control technique.
This gives the same degree of entanglement but a higher degree of purity than
the local technique previously considered [S. Mancini, Phys. Rev. A {\bf 73},
010304(R) (2006)].Comment: 10 pages, 5 figure
Rapid state purification protocols for a Cooper pair box
We propose techniques for implementing two different rapid state purification
schemes, within the constraints present in a superconducting charge qubit
system. Both schemes use a continuous measurement of charge (z) measurements,
and seek to minimize the time required to purify the conditional state. Our
methods are designed to make the purification process relatively insensitive to
rotations about the x-axis, due to the Josephson tunnelling Hamiltonian. The
first proposed method, based on the scheme of Jacobs [Phys. Rev. A 67,
030301(R) (2003)] uses the measurement results to control bias (z) pulses so as
to rotate the Bloch vector onto the x-axis of the Bloch sphere. The second
proposed method, based on the scheme of Wiseman and Ralph [New J. Phys. 8, 90
(2006)] uses a simple feedback protocol which tightly rotates the Bloch vector
about an axis almost parallel with the measurement axis. We compare the
performance of these and other techniques by a number of different measures.Comment: 14 pages, 14 figures. v2: Revised version after referee comments.
Accepted for publication by Physical Review
Heat Transfer Operators Associated with Quantum Operations
Any quantum operation applied on a physical system is performed as a unitary
transformation on a larger extended system. If the extension used is a heat
bath in thermal equilibrium, the concomitant change in the state of the bath
necessarily implies a heat exchange with it. The dependence of the average heat
transferred to the bath on the initial state of the system can then be found
from the expectation value of a hermitian operator, which is named as the heat
transfer operator (HTO). The purpose of this article is the investigation of
the relation between the HTOs and the associated quantum operations. Since, any
given quantum operation on a system can be realized by different baths and
unitaries, many different HTOs are possible for each quantum operation. On the
other hand, there are also strong restrictions on the HTOs which arise from the
unitarity of the transformations. The most important of these is the Landauer
erasure principle. This article is concerned with the question of finding a
complete set of restrictions on the HTOs that are associated with a given
quantum operation. An answer to this question has been found only for a subset
of quantum operations. For erasure operations, these characterizations are
equivalent to the generalized Landauer erasure principle. For the case of
generic quantum operations however, it appears that the HTOs obey further
restrictions which cannot be obtained from the entropic restrictions of the
generalized Landauer erasure principle.Comment: A significant revision is made; 33 pages with 2 figure
Optimal Unravellings for Feedback Control in Linear Quantum Systems
For quantum systems with linear dynamics in phase space much of classical
feedback control theory applies. However, there are some questions that are
sensible only for the quantum case, such as: given a fixed interaction between
the system and the environment what is the optimal measurement on the
environment for a particular control problem? We show that for a broad class of
optimal (state-based) control problems (the stationary
Linear-Quadratic-Gaussian class), this question is a semi-definite program.
Moreover, the answer also applies to Markovian (current-based) feedback.Comment: 5 pages. Version published by Phys. Rev. Let
Stability, Gain, and Robustness in Quantum Feedback Networks
This paper concerns the problem of stability for quantum feedback networks.
We demonstrate in the context of quantum optics how stability of quantum
feedback networks can be guaranteed using only simple gain inequalities for
network components and algebraic relationships determined by the network.
Quantum feedback networks are shown to be stable if the loop gain is less than
one-this is an extension of the famous small gain theorem of classical control
theory. We illustrate the simplicity and power of the small gain approach with
applications to important problems of robust stability and robust
stabilization.Comment: 16 page
Nonlocal Effects on the Magnetic Penetration Depth in d-wave Superconductors
We show that, under certain conditions, the low temperature behavior of the
magnetic penetration depth of a pure d-wave superconductor is
determined by nonlocal electrodynamics and, contrary to the general belief, the
deviation is proportional to T^2 and
not T. We predict that the dependence, due to
nonlocality, should be observable experimentally in nominally clean high-T_c
superconductors below a crossover temperature . Possible complications due to impurities, surface quality and
crystal axes orientation are discussed.Comment: REVTeX3.0; 4 pages, 1 EPS figure (included); Submitted to Phys. Rev.
Let
Modeling Method for Increased Precision and Scope of Directly Measurable Fluxes at a Genome-Scale
Metabolic flux analysis (MFA) is
considered to be the gold standard
for determining the intracellular flux distribution of biological
systems. The majority of work using MFA has been limited to core models
of metabolism due to challenges in implementing genome-scale MFA and
the undesirable trade-off between increased scope and decreased precision
in flux estimations. This work presents a tunable workflow for expanding
the scope of MFA to the genome-scale without trade-offs in flux precision.
The genome-scale MFA model presented here, iDM2014, accounts for 537
net reactions, which includes the core pathways of traditional MFA
models and also covers the additional pathways of purine, pyrimidine,
isoprenoid, methionine, riboflavin, coenzyme A, and folate, as well
as other biosynthetic pathways. When evaluating the iDM2014 using
a set of measured intracellular intermediate and cofactor mass isotopomer
distributions (MIDs), it was found that
a total of 232 net fluxes of central and peripheral metabolism could
be resolved in the <i>E. coli</i> network. The increase
in scope was shown to cover the full biosynthetic route to an expanded
set of bioproduction pathways, which should facilitate applications
such as the design of more complex bioprocessing strains and aid in
identifying new antimicrobials. Importantly, it was found that there
was no loss in precision of core fluxes when compared to a traditional
core model, and additionally there was an overall increase in precision
when considering all observable reactions
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