Prospectus, November 18, 2015

Honoring our Veterans, Parkland College hosts Veterans Day ceremony, Parkland\u27s rebranding positively impacting students, Accessibility at Parkland Part one: Mental illness and intellectual disability, Dual credit program offers chance to get ahead, Great American Smokeout, Respiratory Care Club and Wellness Center team up to end smoking, Paris attacks lead Americans to wonder about US safety(AP), The Great Opportunity(Instructor of Japanese Language Parkland College), House speaker calls for ‘pause’ in Syrian refugees(AP), \u27Noises Off\u27 Premieres at The Harold and Jean Miner Theatrehttps://spark.parkland.edu/prospectus_2015/1025/thumbnail.jp

Prospectus, December 9, 2015

NUMBER ONE: COACH CLIFF HASTINGS DISCUSSES HISTORIC SEASON; Study abroad: Costa Rica; Parkland student body examined; 6 arraigned in kidnap of 2 college students; Vandalized menorah rededicated at U of I; The value of an education; Social media, the new megaphone for violent perpetrators; The importance of choosing your news sources wisely; Trump shrugs off GOP rejections of proposal to ban Muslims; Open mic hosted by Student Government; 2015 State of the Art: Ceramics Invitational at Gierz Art Gallery; Men\u27s basketball!! gains momentum, confidence on the courthttps://spark.parkland.edu/prospectus_2015/1031/thumbnail.jp

Older people and medication taking behaviour: A review of the literature

Background: Older people represent a sizeable population of the UK. Many older people receive drug treatment for long term conditions. Adherence with medication is therefore an important clinical, financial and resource intensive concern. Objectives: This review aimed to examine patient’s beliefs, perceptions and views in relation to adherence with medication. Design: A comprehensive search of the literature was undertaken using numerous approaches. The search of revealed 30 research papers. Findings: Articles were initially evaluated using Critical Appraisal Skills Programme principles to identify those relevant to the review. Relevant studies were then subjected to a narrative analysis to assist the development of relevant themes. Four themes were identified; experience of adherence; perceptions and attitudes to medication adherence and non-adherence; patients acceptance of their illness and impact on medication taking behaviour and shared decision making. Conclusions: The findings of this review imply that there is a need for more emphasis on shared decision making between the older patient and the prescriber. Using this approach adherence with medication may improve. There is also a need to develop a standardized measure of medication adherence

Prospectus, October 28, 2015

Art Theater\u27s \u27Shocktober\u27 a scream for community members, Rainy summer yields fewer pumpkins, Personal identity, gender and sexuality growing topics of discussion at Parkland, Aviation team makes nationals, Professors share experiences with visiting Finnish educators, Many jobs available to those with associate degrees, Area high schools visit arts dept. at Parkland, Are you reading this? Print news changing ways to remain relevant, GOP says Trump tops list of electable(AP), Women\u27s soccer dominates Lynx 10-0, Happy Halloween! Local Halloween haunts and fall activitieshttps://spark.parkland.edu/prospectus_2015/1022/thumbnail.jp

Prospectus, October 7, 2015

Black Student Success Project continues informative workshops, Parkland job fair invites women to consider law enforcement, Campus Sustainability Month highlighted, Science lectures open to students, community, Equestrian team starts fresh season with new coach, elected officers, Parkland offers innovative tech for students, Coast Guard: Missing ship sank, 1 body found, search ongoing(AP), Biden backs transgender military service(AP), Clinton pushing new gun controls after Oregon shooting(AP), What\u27s happening at the Giertz Gallery?, Women\u27s basketball begins quest for national championship, Women’s soccer beats SWIC 3-0,https://spark.parkland.edu/prospectus_2015/1019/thumbnail.jp

Prospectus, November 11, 2015

Collaboration provides comprehensive approach to education, Nursing program offers study abroad in Ecuador, Students lose MAP grant money, Ferguson protests influence actions at U. of Missouri(AP), Toys have best year in a decade(AP), Bubble yuck: Crews melt chewed gum off famed Seattle wall(AP), Clinton pushes back against GOP on veterans\u27 health issues(AP), Smaller cast of Republican candidates to face off in debate(AP), Escape room challenge sparks friendly competition, Parkland Theatre’s ‘Noises Off!’ extremely funny, Parkland volleyball advances to regional final, Parkland baseball puts priority on educationhttps://spark.parkland.edu/prospectus_2015/1024/thumbnail.jp

Mitochondrial Dysfunction is Evident in Lewis Lung Carcinoma-Induced Muscle Wasting

Cancer cachexia is a paraneoplastic syndrome associated with adverse prognosis and shortened survival. The defining feature of cachexia is extensive muscle atrophy leading to progressive functional impairments. The molecular mechanisms responsible for the rapid muscle wasting are not fully elucidated. Based on emerging evidence, we developed the hypothesis cachectic muscle wasting is caused by mitochondrial dysfunction increasing reactive oxygen species production leading to global oxidative stress. To test this hypothesis we utilized the well-established Lewis-Lung Carcinoma (LLC) model of cancer cachexia. The time-course study consisted of one, two, three and four week LLC tumor bearing mice and age-matched four week saline (PBS) control (Ctrl) mice. Tumors were implanted into the hind flank at 1X106 cells in 100 µL PBS. The plantaris was weighed for wet mass then teased into small fiber bundles and permeabilized for the quantification of mitochondrial function. Mitochondrial dysfunction was classified by a decrease in the respiratory control ratio (RCR), which is the ratio of state 3 (maximal ADP stimulated respiration) to state 4 (oligomycin-induced leak respiration). Muscle mass progressively declined over the time-course, reaching significance at 4 weeks (Ctrl vs 4-week, p\u3c0.05). Mitochondrial function was not different among groups, however individual a priori comparison between groups revealed that 4wk cancer animals exhibited marked mitochondrial dysfunction compared to all other groups (p\u3c0.05). These data demonstrate that late stage cancer-induced muscle wasting is associated with significant mitochondrial dysfunction

Mitochondrial Dysfunction in Diaphragm Muscle Precedes the Cachectic Phenotype in LLC Tumor-Bearing Mice.

The defining feature of cancer cachexia is extensive weight loss and skeletal muscle atrophy. It is clinically important because cachexia reduces patient survival, results in functional impairment, and is estimated to be directly responsible for 20-40% of cancer deaths. Unfortunately, no clinical therapy exists and therefore, it is important to understand the molecular mechanisms responsible for rapid muscle wasting. Compared to limb muscles, the diaphragm is relatively understudied in cancer cachexia, but is likely to be adversely affected because cachexia is a systemic disease. Wasting of the primary inspiratory muscle may result in difficulty breathing and inability to adjust minute ventilation in response to a respiratory challenge. Based on emerging evidence, it is clear that oxidative stress is present in cachexia-induced wasting of the diaphragm; PURPOSE: we developed the hypothesis that mitochondrial dysfunction in the diaphragm precedes cachexia. METHODS: 1X106 Lewis Lung Carcinoma cells (LLC) or Phosphate-Buffered Saline (PBS, control) were implanted to the hind-flank of C57BL6/J mice at 8 wks of age. Tumors were allowed to develop for 1, 2, 3, or 4 wks. At designated time points diaphragms were collected and mitochondrial function was assessed by respiration and ROS production. RESULTS: Cancer cachexia was evident only at the 4 wk time point demonstrated by decrease in body mass and muscle atrophy in several limb muscles. Mitochondrial respiration, assessed by respiratory control ratio (state3/state 4 respiration), was significantly lower at 1 wk (pCONCLUSIONS:The molecular events that lead to muscle atrophy in cancer cachexia are unknown. We demonstrate that two hallmarks of mitochondrial dysfunction, altered respiration and ROS production, occur in the diaphragm well before the cancer cachexia phenotype is evident in the LLC model. These data suggest that the mitochondria are likely a suitable target to treat or prevent cancer cachexia-induced muscle wasting in the diaphragm

Modelling scour around submerged objects with TELEMAC3D - GAIA

Hydrodynamic