Harvesting Multiqubit Entanglement from Ultrastrong Interactions in Circuit Quantum Electrodynamics

We analyze a multi-qubit circuit QED system in the regime where the qubit-photon coupling dominates over the system’s bare energy scales. Under such conditions a manifold of low-energy states with a high degree of entanglement emerges. Here we describe a time-dependent protocol for extracting these quantum correlations and converting them into well-defined multi-partite entangled states of non-interacting qubits. Based on a combination of various ultrastrong-coupling effects the protocol can be operated in a fast and robust manner, while still being consistent with experimental constraints on switching times and typical energy scales encountered in superconducting circuits. Therefore, our scheme can serve as a probe for otherwise inaccessible correlations in strongly-coupled circuit QED systems. It also shows how such correlations can potentially be exploited as a resource for entanglement-based applications

Altered translation of GATA1 in Diamond-Blackfan anemia

Ribosomal protein haploinsufficiency occurs in diverse human diseases including Diamond-Blackfan anemia (DBA)[superscript 1, 2], congenital asplenia[superscript 3] and T cell leukemia[superscript 4]. Yet, how mutations in genes encoding ubiquitously expressed proteins such as these result in cell-type– and tissue-specific defects remains unknown[superscript 5]. Here, we identify mutations in GATA1, encoding the critical hematopoietic transcription factor GATA-binding protein-1, that reduce levels of full-length GATA1 protein and cause DBA in rare instances. We show that ribosomal protein haploinsufficiency, the more common cause of DBA, can lead to decreased GATA1 mRNA translation, possibly resulting from a higher threshold for initiation of translation of this mRNA in comparison with other mRNAs. In primary hematopoietic cells from patients with mutations in RPS19, encoding ribosomal protein S19, the amplitude of a transcriptional signature of GATA1 target genes was globally and specifically reduced, indicating that the activity, but not the mRNA level, of GATA1 is decreased in patients with DBA associated with mutations affecting ribosomal proteins. Moreover, the defective hematopoiesis observed in patients with DBA associated with ribosomal protein haploinsufficiency could be partially overcome by increasing GATA1 protein levels. Our results provide a paradigm by which selective defects in translation due to mutations affecting ubiquitous ribosomal proteins can result in human disease.National Institutes of Health (U.S.) (Grant P01 HL32262)National Institutes of Health (U.S.) (Grant U54 HG003067-09

Gender differences in marital status moderation of genetic and environmental influences on subjective health

From the IGEMS Consortium, data were available from 26,579 individuals aged 23 to 102 years on 3 subjective health items: self-rated health (SRH), health compared to others (COMP), and impact of health on activities (ACT). Marital status was a marker of environmental resources that may moderate genetic and environmental influences on subjective health. Results differed for the 3 subjective health items, indicating that they do not tap the same construct. Although there was little impact of marital status on variance components for women, marital status was a significant modifier of variance in all 3 subjective health measures for men. For both SRH and ACT, single men demonstrated greater shared and nonshared environmental variance than married men. For the COMP variable, genetic variance was greater for single men vs. married men. Results suggest gender differences in the role of marriage as a source of resources that are associated with subjective health

Continuous assessment in process engineering education – two case studies

BACKGROUND. Development of higher engineering education requires under-standing on teaching, learning and assessment. The content being taught and boundary conditions, such as available resources, must be taken into consideration. In practice it is not possible to implement everything that is presented as desirable in educational research and a compromise is needed, where such a teaching, learning and assessment environment is created that is both theoretically sound and useful in practice. PURPOSE. The purpose of this report is twofold: Firstly, to present a teaching, learning and assessment environment which can be used as a base for educational practice and development. Secondly, we present two cases, in both of which the implementation is based mainly on the ideas of constructive alignment and the key element has been to find those assessment procedures that are most useful for the attainment of learning outcomes. SCOPE/METHOD. The report begins with a discussion on research about suitable teaching, learning and assessment environment with special emphasis on constructive alignment. Continuous assessment with its pros and cons and uses in our environ-ment is also covered. Our report ends with our two educational cases and discussion. CONCLUSION. Based on quantitative (pass rate, grades) and qualitative data (student feedback) obtained from our cases, we claim that the use of continuous assessment, which can also be justified by learning and assessment research, is an efficient approach in creating a well functioning course. Continuous assessment also provides us with real-time information about student learning and this enables us to make well founded changes even during a course

Ultrastrong-coupling circuit QED in the radio-frequency regime

13 pags., 7 figs., 1 tab., 1 app.We study a circuit QED setup where multiple superconducting qubits are ultrastrongly coupled to a single radio-frequency resonator. In this extreme parameter regime of cavity QED the dynamics of the electromagnetic mode is very slow compared to all other relevant timescales and can be described as an effective particle moving in an adiabatic energy landscape defined by the qubits. The focus of this paper is placed on settings with two or multiple qubits, where different types of symmetry-breaking transitions in the ground- and excited-state potentials can occur. Specifically, we show how the change in the level structure and the wave-packet dynamics associated with these transition points can be probed via conventional excitation spectra and Ramsey measurements performed at GHz frequencies. More generally, this analysis demonstrates that state-of-the-art circuit QED systems can be used to access a whole range of particlelike quantum-mechanical phenomena beyond the usual paradigm of coupled qubits and oscillators.This work was supported by the Austrian Science Fund through Grant No. P 31701-N27 and DK CoQuS Grant No. W 1210, and by an ESQ Discovery Grant of the Austrian Academy of Sciences (A.W.). J.J.G.-R. acknowledges support from AEI Project No.PGC2018-094792-B-I00,CSIC Research Platform PTI-001, and CAM/FEDER Project No. S2018/TCS-4342 (QUITEMAD-CM)

Koulutuksen laatuyksikköhakemus ja pedagoginen johtajuus

Tiivistelmä Tässä raportissa on esitetty prosessi- ja ympäristötekniikan osaston koulutuksen laatuyksikköhakemuksen laatimiseen, arviointiin ja hyötykäyttöön liittyviä seikkoja. Teksti on kirjoitettu kahdessa osassa; osan I on kirjoittanut Juha Jaako ja osan II on kirjoittanut Eetu-Pekka Heikkinen. Tekstin osassa I käsitellään laatuyksikköjen valintaan liittyviä asioita ja käydään läpi prosessi- ja ympäristötekniikan osaston hakemuksen tärkeimpiä reunaehtoja ja hakemuksen teosta saatuja kokemuksia. Tekstissä on myös käsitelty laatuyksikköjen valintaan liittyviä kriteerejä. Tekstin osa II on kirjoitettu matkakertomuksen muotoon ja osassa on pohdittu seuraavaa kysymystä: Mitä laatuyksikköhakemuksen onnistumisen jälkeen? Keskeinen seikka on pedagogisen johtajuuden käsite

A triangular approach to integrate research, education and practice in higher engineering education

Abstract Separate approaches in engineering education, research and practice are not very useful when preparing students for working life; instead, integration of education, research and industrial practices is needed. A triangular approach (TA) as a method to accomplish this integration and as a method to provide students with integrated expertise is proposed. The results from the application of TA, both at the course and programme level, indicate that the approach is suitable for developing engineering education. The student pass rate for courses where TA has been used has been higher than for previous approaches, and the student feedback has been very positive. Although TA aims to take both theoretical and practical aspects of engineering as well as research and education into account, the approach concentrates mainly on activities and therefore leaves the goals of these activities as well as the values behind these goals uncovered