Heidegger's destruction of Aristotle's ontology in being and time

The focus of my thesis is Heidegger's critical interpretation of Aristotle's ontology in Being and Time. I will juxtapose Heidegger's project of a fundamental ontology, that is to say, his attempt to work out the meaning of being as such, with Aristotle's attempt to ground a science of being qua being and, in so doing, I hope to shed some more light on the raising of the question of the meaning of being (Seinsfrage). I try to show that although Aristotle, in his account of being, did not explicitly raise this question, his ontology nonetheless prepared the ground for Heidegger to raise the Seinsfrage. In the first half of the thesis, I selectively present Heidegger's account of being in Being and Time. My exegesis of the existential analytic of Dasein in terms of temporality will provide the relevant and required background considerations for the argument I present in the latter half of the thesis. I argue that Heidegger's critical remarks in The Basic Problems of Phenomenology concerning Aristotle's interpretation of time are paramount to understanding his critique of Aristotle's interpretation of being in the primary sense as ousia. I place this argument in the wider context of Heidegger's reading of Aristotle in the Introduction, where I provide a narrative account of Heidegger's engagement with Aristotle through a parallel discussion of Heidegger's other key works on Aristotle and the relevant secondary literature. Although it will be impossible to give an exhaustive overview of Heidegger's account of being, or of the entirety of his philosophical consideration of Aristotle, my textual focus, limited by the constraints of an MPhil thesis, will concern those texts of Heidegger's that I deem most helpful for the attainment of my stated aim

Podoplanin-positive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion

Podoplanin (PDPN) is a well established lymphatic endothelial marker and has frequently been observed in cancer cells at the edge of cancer masses. Previous studies investigating the association between PDPN expression and patient prognosis have had contradictory results. In the present study, it was hypothesized that the different locations of PDPNpositive cells may explain these varying results. The present study aimed to focus on PDPN expression at the edge of esophageal cancer cell nests. In order to analyze the clinical significance of this PDPN expression, immunohistochemistry was performed using esophageal cancer tissue microarrays. PDPN expression at the edge of the cancer cell nest was found to be significantly associated with invasion (P<0.05) and poor prognosis (P<0.001) in patients with cancer. To further investigate the role of PDPN expression in cancer cells, the PDPN gene was cloned and transfected into esophageal squamous cell carcinoma (ESCC) cell lines. PDPN expression was also knocked down using small interfering RNA. PDPNpositive cancer cells were found to exhibit invasion characteristics. Thus, PDPN expression at the edge of a cancer cell nest may indicate invasion and represent a poor prognostic factor for ESCCs.published_or_final_versio

Transitional care for a patient with chronic obstructive pulmonary disease

2011-2012 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

The Role of Implant Position on Longâ Term Success

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141259/1/cap0187.pd

Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Molecular orientation-dependent energetic shifts in solution-processed non-fullerene acceptors and their impact on organic photovoltaic performance

The non-fullerene acceptors (NFAs) employed in state-of-art organic photovoltaics (OPVs) often exhibit strong quadrupole moments which can strongly impact on material energetics. Herein, we show that changing the orientation of Y6, a prototypical NFA, from face-on to more edge-on by using different processing solvents causes a significant energetic shift of up to 210 meV. The impact of this energetic shift on OPV performance is investigated in both bilayer and bulk-heterojunction (BHJ) devices with PM6 polymer donor. The device electronic bandgap and the rate of non-geminate recombination are found to depend on the Y6 orientation in both bilayer and BHJ devices, attributed to the quadrupole moment-induced band bending. Analogous energetic shifts are also observed in other common polymer/NFA blends, which correlates well with NFA quadrupole moments. This work demonstrates the key impact of NFA quadruple moments and molecular orientation on material energetics and thereby on the efficiency of high-performance OPVs

Superderivations for Modular Graded Lie Superalgebras of Cartan-type

Superderivations for the eight families of finite or infinite dimensional graded Lie superalgebras of Cartan-type over a field of characteristic $p>3$ are completely determined by a uniform approach: The infinite dimensional case is reduced to the finite dimensional case and the latter is further reduced to the restrictedness case, which proves to be far more manageable. In particular, the outer superderivation algebras of those Lie superalgebras are completely determined

Protective Effect of Ginseng Polysaccharides on Influenza Viral Infection

Ginseng polysaccharide has been known to have multiple immunomodulatory effects. In this study, we investigated whether Panax ginseng polysaccharide (GP) would have a preventive effect on influenza infection. Administration of mice with GP prior to infection was found to confer a survival benefit against infection with H1N1 (A/PR/8/34) and H3N2 (A/Philippines/82) influenza viruses. Mice infected with the 2009 H1N1 virus suspended in GP solution showed moderately enhanced survival rates and lower levels of lung viral titers and the inflammatory cytokine (IL-6). Daily treatment of vaccinated mice with GP improved their survival against heterosubtypic lethal challenge. This study demonstrates the first evidence that GP can be used as a remedy against influenza viral infection

Unusual Location of the Geotail Magnetopause Near Lunar Orbit: A Case Study

The Earth's magnetopause is highly variable in location and shape and is modulated by solar wind conditions. On 8 March 2012, the ARTEMIS probes were located near the tail current sheet when an interplanetary shock arrived under northward interplanetary magnetic field conditions and recorded an abrupt tail compression at ∼(‐60, 0, ‐5) RE in Geocentric Solar Ecliptic coordinate in the deep magnetotail. Approximately 10 minutes later, the probes crossed the magnetopause many times within an hour after the oblique interplanetary shock passed by. The solar wind velocity vector downstream from the shock was not directed along the Sun‐Earth line but had a significant Y component. We propose that the compressed tail was pushed aside by the appreciable solar wind flow in the Y direction. Using a virtual spacecraft in a global magnetohydrodynamic (MHD) simulation, we reproduce the sequence of magnetopause crossings in the X‐Y plane observed by ARTEMIS under oblique shock conditions, demonstrating that the compressed magnetopause is sharply deflected at lunar distances in response to the shock and solar wind VY effects. The results from two different global MHD simulations show that the shocked magnetotail at lunar distances is mainly controlled by the solar wind direction with a timescale of about a quarter hour, which appears to be consistent with the windsock effect. The results also provide some references for investigating interactions between the solar wind/magnetosheath and lunar nearside surface during full moon time intervals, which should not happen in general