6,185 research outputs found
Factors modulating the secretion of thyrotropin and other hormones of the thyroid axis.
The first portion of this paper is devoted to an overview of the normal function of the hypothalamo-pituitary-thyroid axis. This section emphasizes areas of current research interest and it identifies several sites and mechanisms that are potentially important interfaces with toxins or toxic mechanisms. We then describe an in vitro technique for the continuous superfusion of enzymatically dispersed pituitary cells; this approach is particularly valuable in studying the dynamics of the TSH responses to the factors known (or suspected) to regulate TSH secretion in vivo. Using this technique, we have found that 10(-5)M prostaglandin (PG)I2 stimulates TSH secretion without altering the response to TRH (10(-8)M), and that this stimulation is not due to its rapid conversion to 6-keto PGF1 alpha. In contrast PGs of the E series (PGE1 and PGE2, 10(-5)M) increase responsiveness to TRH but have no effect alone. We found no effects of any of the other prostanoids tested (PGs A2, B2, F1 alpha, F2 alpha, thromboxanes A2 and B2, and the endoperoxide analog, U-44069. Somatostain (10(-9)M inhibits TRH-induced TSH secretion, but does not alter the responsiveness to PGI2. These findings suggest that somatostatin blocks TSH secretion at a point that is functionally prior to the involvement of the PGs, and perhaps does so by blocking synthesis or limiting availability of selected PGs
Delay-Coordinates Embeddings as a Data Mining Tool for Denoising Speech Signals
In this paper we utilize techniques from the theory of non-linear dynamical
systems to define a notion of embedding threshold estimators. More specifically
we use delay-coordinates embeddings of sets of coefficients of the measured
signal (in some chosen frame) as a data mining tool to separate structures that
are likely to be generated by signals belonging to some predetermined data set.
We describe a particular variation of the embedding threshold estimator
implemented in a windowed Fourier frame, and we apply it to speech signals
heavily corrupted with the addition of several types of white noise. Our
experimental work seems to suggest that, after training on the data sets of
interest,these estimators perform well for a variety of white noise processes
and noise intensity levels. The method is compared, for the case of Gaussian
white noise, to a block thresholding estimator
Episodic medication adherence in adolescents and young adults with perinatally acquired HIV: a within-participants approach
Due to the success of antiretroviral (ART) medications, young people living with perinatally acquired HIV (PHIV+) are now surviving into adolescence and young adulthood. Understanding factors influencing ART non-adherence in this group is important in developing effective adherence interventions. Most studies of ART adherence in HIV-positive populations assess differences in adherence levels and adherence predictors between participants, over a period of time (global adherence). Many individuals living with HIV, however, including PHIV+ young people, take medication inconsistently. To investigate this pattern of adherence, a within-participants design, focussing on specific episodes of adherence and non-adherence, is suitable (episodic adherence). A within-participants design was used with 29 PHIV+ young people (17 female, median age 17 years, range 14–22 years), enrolled in the UK Adolescents and Adults Living with Perinatal HIV cohort study. Participants were eligible if they could identify one dose of medication taken and one dose they had missed in the previous two months. For each of the two episodes (one adherent, one non-adherent), behavioural factors (whom they were with, location, routine, day, reminders) and psychological factors at the time of the episode (information about medication, adherence motivation, perceived behavioural skills to adhere to medication – derived from the Information-Motivation-Behavioural Skills (IMB) Model – and affect) were assessed in a questionnaire. Non-adherence was significantly associated with weekend days (Friday to Sunday versus Monday to Thursday, p = .001), lack of routine (p = .004), and being out of the home (p = .003), but not with whom the young person was with or whether they were reminded to take medication. Non-adherence was associated with lower levels of behavioural skills (p < .001), and lower positive affect (p = .005). Non-adherence was not significantly associated with negative affect, information about ART, or ART motivation. The use of situationally specific strategies to enhance adherence in young people who take their medication inconsistently is proposed
Engaging postgraduate students and supporting higher education to enhance the 21st century student experience:Final Report
Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs
We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design. We studied psychiatric patients, a high risk group for co-morbid pain disorders and increased perception of pain. For discovery, we used a powerful within-subject longitudinal design. We were successful in identifying blood gene expression biomarkers that were predictive of pain state, and of future emergency department (ED) visits for pain, more so when personalized by gender and diagnosis. MFAP3, which had no prior evidence in the literature for involvement in pain, had the most robust empirical evidence from our discovery and validation steps, and was a strong predictor for pain in the independent cohorts, particularly in females and males with PTSD. Other biomarkers with best overall convergent functional evidence for involvement in pain were GNG7, CNTN1, LY9, CCDC144B, and GBP1. Some of the individual biomarkers identified are targets of existing drugs. Moreover, the biomarker gene expression signatures were used for bioinformatic drug repurposing analyses, yielding leads for possible new drug candidates such as SC-560 (an NSAID), and amoxapine (an antidepressant), as well as natural compounds such as pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), and apigenin (a plant flavonoid). Our work may help mitigate the diagnostic and treatment dilemmas that have contributed to the current opioid epidemic
Model for the structure function constant for index of refraction fluctuations in Rayleigh-Benard turbulence
A model for the structure function constant associated with index of
refraction fluctuations in Rayleigh-Benard turbulence is developed. The model
is based upon the following assumptions: (1) the turbulence is homogeneous and
isotropic at or near the mid-plane, (2) the rate of production is in balance
with the rate of dissipation, (3) an inertial region exists, and (4) estimates
for the rate of dissipation of temperature fluctuations and of turbulent
kinetic energy can be made by assuming that the large-scale turbulence is
dissipated in one eddy turnover time. From these assumptions, the dependence of
the structure function on the geometry, heat flux, and the properties of the
fluid is obtained. The model predicts that the normalized structure function
constant is independent of the Rayleigh number. To verify the model, numerical
simulations of Rayleigh-Benard turbulence were performed using two different
approaches: an in-house code based on a pseudo-spectral method, and a finite
volume code which employs a model for the smallest scales of the turbulence.
The model was found to agree with the results of the simulations, thereby
lending support for the assumptions underlying the theory.Comment: 25 pages, 10 figures, 1 tabl
Geometric scaling in the spectrum of an electron captured by a stationary finite dipole
We examine the energy spectrum of a charged particle in the presence of a
{\it non-rotating} finite electric dipole. For {\emph{any}} value of the dipole
moment above a certain critical value p_{\mathrm{c}}$ an infinite series of
bound states arises of which the energy eigenvalues obey an Efimov-like
geometric scaling law with an accumulation point at zero energy. These
properties are largely destroyed in a realistic situation when rotations are
included. Nevertheless, our analysis of the idealised case is of interest
because it may possibly be realised using quantum dots as artificial atoms.Comment: 5 figures; references added, outlook section reduce
Dynamical modeling of collective behavior from pigeon flight data: flock cohesion and dispersion
Several models of flocking have been promoted based on simulations with
qualitatively naturalistic behavior. In this paper we provide the first direct
application of computational modeling methods to infer flocking behavior from
experimental field data. We show that this approach is able to infer general
rules for interaction, or lack of interaction, among members of a flock or,
more generally, any community. Using experimental field measurements of homing
pigeons in flight we demonstrate the existence of a basic distance dependent
attraction/repulsion relationship and show that this rule is sufficient to
explain collective behavior observed in nature. Positional data of individuals
over time are used as input data to a computational algorithm capable of
building complex nonlinear functions that can represent the system behavior.
Topological nearest neighbor interactions are considered to characterize the
components within this model. The efficacy of this method is demonstrated with
simulated noisy data generated from the classical (two dimensional) Vicsek
model. When applied to experimental data from homing pigeon flights we show
that the more complex three dimensional models are capable of predicting and
simulating trajectories, as well as exhibiting realistic collective dynamics.
The simulations of the reconstructed models are used to extract properties of
the collective behavior in pigeons, and how it is affected by changing the
initial conditions of the system. Our results demonstrate that this approach
may be applied to construct models capable of simulating trajectories and
collective dynamics using experimental field measurements of herd movement.
From these models, the behavior of the individual agents (animals) may be
inferred
Clinical outcomes in adolescents with perinatally acquired HIV (PAH) transitioning from paediatric to adult care in a large regional HIV clinic in London
Chaos and localization in the wavefunctions of complex atoms NdI, PmI and SmI
Wavefunctions of complex lanthanide atoms NdI, PmI and SmI, obtained via
multi-configuration Dirac-Fock method, are analyzed for density of states in
terms of partial densities, strength functions (), number of principal
components () and occupancies (\lan n_\alpha \ran^E) of single
particle orbits using embedded Gaussian orthogonal ensemble of one plus
two-body random matrix ensembles [EGOE(1+2)]. It is seen that density of states
are in general multi-modal, 's exhibit variations as function of the
basis states energy and 's show structures arising from localized
states. The sources of these departures from EGOE(1+2) are investigated by
examining the partial densities, correlations between , and
\lan n_\alpha \ran^E and also by studying the structure of the Hamiltonian
matrices. These studies point out the operation of EGOE(1+2) but at the same
time suggest that weak admixing between well separated configurations should be
incorporated into EGOE(1+2) for more quantitative description of chaos and
localization in NdI, PmI and SmI.Comment: There are 9 figure
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