Pulmonary Epithelial Integrity in Children: Relationship to Ambient Ozone Exposure and Swimming Pool Attendance

Airway irritants such as ozone are known to impair lung function and induce airway inflammation. Clara cell protein (CC16) is a small anti-inflammatory protein secreted by the nonciliated bronchiolar Clara cells. CC16 in serum has been proposed as a noninvasive and sensitive marker of lung epithelial injury. In this study, we used lung function and serum CC16 concentration to examine the pulmonary responses to ambient O(3) exposure and swimming pool attendance. The measurements were made on 57 children 10–11 years of age before and after outdoor exercise for 2 hr. Individual O(3) exposure was estimated as the total exposure dose between 0700 hr until the second blood sample was obtained (mean O(3) concentration/m(3) × hours). The maximal 1-hr value was 118 μg/m(3) (59 ppb), and the individual exposure dose ranged between 352 and 914 μg/m(3)hr. These O(3) levels did not cause any significant changes in mean serum CC16 concentrations before or after outdoor exercise, nor was any decrease in lung function detected. However, children who regularly visited chlorinated indoor swimming pools had significantly lower CC16 levels in serum than did nonswimming children both before and after exercise (respectively, 57 ± 2.4 and 53 ± 1.7 μg/L vs. 8.2 ± 2.8 and 8.0 ± 2.6 μg/L; p < 0.002). These results indicate that repeated exposure to chlorination by-products in the air of indoor swimming pools has adverse effects on the Clara cell function in children. A possible relation between such damage to Clara cells and pulmonary morbidity (e.g., asthma) should be further investigated

Fragments of mind: a thesis on the subject of experience, the structure of consciousness, and split-brain patients

Neuropsychological research on so-called split-brain patients—individuals whose corpus callosum has been severed as a treatment for severe epilepsy—has revealed the possibility of startling breakdowns in the transmission of sensory information between the cerebral hemispheres. These experimental results have often been interpreted as demonstrating that split-brain patients have two streams of consciousness. In opposition to such views, this thesis argues for a conception of split-brain patients as having a single stream of consciousness that’s disunified in highly specific experimental settings but unified outside of those settings. It is also argued that conceptions of split-brain patients as having two unified streams of consciousness and conceptions according to which they have one consistently unified stream of consciousness rely on a mistaken assumption: That a set of experiences belong to a stream of consciousness if and only if all the contemporaneous experiences in the stream are unified with each other

”BERÄTTA FÖR MIG”: AN EFFICIENT METHOD TO CO-CREATE CULTURE CONTENTS WITH YOUR AUDIENCES IN CORONA TIMES.

From June to December 2020 one regional culture institution (Norrbottens museum) and one municipal culture institution (Kulturens hus) in Luleå, Sweden cooperates to develop a participatory culture project focusing on Corona social impact. The project name is “Berätta för mig” (Tell me) and it is focused on the language. It is conceived as an exploratory tool to connect, dialogue, and start a creative process with your local audiences in a Corona context. The tool was thought of as a way to reconnect with a target group of children from 6 to 12 and their families listening to their fears, expectations, thoughts, and feelings about Corona times. In a very simple way, we invite the participants to choose or create their word which expresses well what is Corona for them. We use this as a starting point to initiate a free creative process that can evolve in different ways: a song, a sculpture, a cooking recipe, a choreography, a poem… We use all these materials to do an exhibition as a participatory end of the project.&nbsp; In this article, we present some of the main features, results and provisional conclusions of the appliance of this methodology and point out some future lines to continue working and refining the strategy

The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals : 131. Lithium and lithium compounds

Lithium is a light soft metal. It reacts with water to form lithium hydroxide, but less vigorously than sodium. All lithium compounds are monovalent. In industry lithium and compounds are used e.g. in the manufacture of aluminium, as a flux in glass, enamel and ceramic industries, for manufacturing of lubricants, as a drying agent, as a reducing agent in organic synthesis, and in batteries. Industrial exposure to lithium and alkaline lithium compounds may give rise to irritation of the respiratory tract, eyes and skin or even corrosive lesions. For lithium hydride no irritant effects were seen below 0.025 mg LiH/m3, whereas at higher levels a tickling sensation in the nose was reported along with nasal discharge. At levels above 0.1 mg LiH/m3 a definite nasal irritation and coughing was experienced. Upper respiratory symptoms and skin irritation at exposure to approximately 0.02-0.05 mg Li/m3 in total dust, as LiOH, has also been reported. No other effects than irritation and corrosive effects have been clearly attributed to occupational exposure to lithium and compounds. However, some lithium compounds are used as drugs in the treatment of affective disorders. Adverse effects of lithium may occur in patients at therapeutic doses. At 12-hours serum lithium concentrations of 0.5-0.8 mM some of the most common side effects are nephrogenic diabetes insipidus, fine hand tremor, weight gain, increased thyroidstimulating hormone values and hypothyreosis. Available data indicate very low serum lithium levels in exposed workers, compared to patients receiving lithium drugs.Litium är en lätt, mjuk metall. Ämnet reagerar med vatten under bildning av litiumhydroxid, men reaktionen sker mindre häftigt än för natrium. Alla litiumföreningar är envärda. Litium med föreningar används industriellt, t ex vid tillverkning av aluminium, som flussmedel inom glas-, emalj- och keramisk industri, vid tillverkning av smörjmedel, som torkmedel, som reduktionsmedel i organisk syntes och i batterier. Litium och alkaliska litiumföreningar kan vid industriell exponering förorsaka irritation av luftvägar, ögon och hud eller t o m frätskador. För litiumhydrid har inga irritationseffekter rapporterats vid lufthalter under 0,025 mg LiH/m3, medan kittlingar i näsan och snuva noterats vid högre nivåer. Vid nivåer över 0,1 mg LiH/m3 har klar näsirritation och hosta rapporterats. Symptom från övre luftvägarna och hudirritation har också rapporterats vid exponering för ca 0,02-0,05 mg Li/m3 som litiumhydroxid (i totaldamm). Inga andra effekter än irritation och frätskador har kunnat tillskrivas litium och dess föreningar vid yrkesmässig exponering. Några litiumföreningar används dock som läkemedel inom psykiatrin och biverkningar kan uppträda hos patienter vid terapeutiska doser. Några av de vanligaste biverkningarna vid 12-timmarsvärdet 0,5-0,8 mM för serumlitium är nefrogen diabetes insipidus, finvågig handtremor, viktökning, förhöjda värden på tyroideastimulerande hormon och hypotyreos. Tillgängliga data indikerar att serumnivåerna av litium hos exponerade arbetare är mycket låga, jämfört med de nivåer som uppmätts hos patienter. Nyckelord: hygieniskt gränsvärde, hälsoeffekter, irritation, litium, litiumhydrid, litiumhydroxid, riskbedömning, toxicitet, ögonskada, översikt

Systemic effects of occupational exposure to arsenic [Elektronisk resurs] : with special reference to peripheral circulation and nerve function

Smelter workers who were exposed to air-borne arsenic for a mean of 23 years, and age-matched referents, were examined with clinical, physiological, and neurophysiological methods. Exposure to arsenic in workroom air was estimated to have been around the Swedish occupational limits, which were 500 yg/m before 1975 and 50 yg/ra thereafter. An increased preval ence of Raynaud's phenomenon and a reduced finger systolic blood pressure (FSP) during local and general cooling were found in the smelter workers. Slight, but significant sub-clinical neuropathy, in the form of slightly reduced nerve conduction velocity (NCV) in two or more peripheral nerves, was more common among the arsenic workers than among the referents. There were positive correlations between cumulative exposure to arsenic, reduced NCV in three peripheral motor nerves, and decrease in FSP during cooling. Arsenic levels in urine were 1 ymole/1 (75 yg/1) in the arsenic workers and 0.1 ymole/1 in the referents. In 21 arsenic workers with no or very low exposure to vibra ting hand tools, the FSP during cooling had increased significantly after 3 years wit h the lower arsenic exposure. There was no change in FSP during the summer vacation, whereas urinary levels of arsenic decreased to normal values. Thus there seems to be a slow improvement of finger blood circ ulation which is independent of short-term fluctuations in the exposure to arsenic. No seasonal variation was found in FSP during cooling with the standardized method used. When the NCV-measurements were repeated five years later the difference between arsenic workers and referents had increased, despite the fact that 14 of the 47 arsenic workers had had no exposure to arsenic during the last 1-5 years. These observations indicate, that in subjects with long term exposure to arsenic, sub-clinical neuropathy is not reversible. Ten milligrams of Ketanserin, a serotonin receptor antagonist, was given intravenously to five arsenic workers with cold-induced vasospasm. Skin temperature and FSP during cooling increased significantly with Ketanserin as compared wit h saline solution. After oral treatment, 2 x 40 mg /day for four weeks, no significant increase of FSP during cooling or rise in skin temperature was found in six arsenic workers and eleven patients with Raynaud's phenomenon. The decrease of vasospastic tendency after intravenous injection of Ketanserin indicated that similar mechanisms might operate in arsenic-induced and other types of Raynaud's phenomenon. A general co nclusion from the five studies in this dissertation is that long-term occupational exposure to arsenic has had adverse effects on the peripheral circulation and nerve conduction. The tendency to vasospasm, but not the sub-clinical neuropathy, seemed to be reversible with decreasing exposure.</p

Systemic effects of occupational exposure to arsenic : with special reference to peripheral circulation and nerve function

Smelter workers who were exposed to air-borne arsenic for a mean of 23 years, and age-matched referents, were examined with clinical, physiological, and neurophysiological methods. Exposure to arsenic in workroom air was estimated to have been around the Swedish occupational limits, which were 500 yg/m before 1975 and 50 yg/ra thereafter. An increased preval ence of Raynaud's phenomenon and a reduced finger systolic blood pressure (FSP) during local and general cooling were found in the smelter workers. Slight, but significant sub-clinical neuropathy, in the form of slightly reduced nerve conduction velocity (NCV) in two or more peripheral nerves, was more common among the arsenic workers than among the referents. There were positive correlations between cumulative exposure to arsenic, reduced NCV in three peripheral motor nerves, and decrease in FSP during cooling. Arsenic levels in urine were 1 ymole/1 (75 yg/1) in the arsenic workers and 0.1 ymole/1 in the referents. In 21 arsenic workers with no or very low exposure to vibra ting hand tools, the FSP during cooling had increased significantly after 3 years wit h the lower arsenic exposure. There was no change in FSP during the summer vacation, whereas urinary levels of arsenic decreased to normal values. Thus there seems to be a slow improvement of finger blood circ ulation which is independent of short-term fluctuations in the exposure to arsenic. No seasonal variation was found in FSP during cooling with the standardized method used. When the NCV-measurements were repeated five years later the difference between arsenic workers and referents had increased, despite the fact that 14 of the 47 arsenic workers had had no exposure to arsenic during the last 1-5 years. These observations indicate, that in subjects with long term exposure to arsenic, sub-clinical neuropathy is not reversible. Ten milligrams of Ketanserin, a serotonin receptor antagonist, was given intravenously to five arsenic workers with cold-induced vasospasm. Skin temperature and FSP during cooling increased significantly with Ketanserin as compared wit h saline solution. After oral treatment, 2 x 40 mg /day for four weeks, no significant increase of FSP during cooling or rise in skin temperature was found in six arsenic workers and eleven patients with Raynaud's phenomenon. The decrease of vasospastic tendency after intravenous injection of Ketanserin indicated that similar mechanisms might operate in arsenic-induced and other types of Raynaud's phenomenon. A general co nclusion from the five studies in this dissertation is that long-term occupational exposure to arsenic has had adverse effects on the peripheral circulation and nerve conduction. The tendency to vasospasm, but not the sub-clinical neuropathy, seemed to be reversible with decreasing exposure.S. 1-54: sammanfattning, s. 55-112: 5 uppsatserdigitalisering@um

Systemic effects of occupational exposure to arsenic : with special reference to peripheral circulation and nerve function

Smelter workers who were exposed to air-borne arsenic for a mean of 23 years, and age-matched referents, were examined with clinical, physiological, and neurophysiological methods. Exposure to arsenic in workroom air was estimated to have been around the Swedish occupational limits, which were 500 yg/m before 1975 and 50 yg/ra thereafter. An increased preval ence of Raynaud's phenomenon and a reduced finger systolic blood pressure (FSP) during local and general cooling were found in the smelter workers. Slight, but significant sub-clinical neuropathy, in the form of slightly reduced nerve conduction velocity (NCV) in two or more peripheral nerves, was more common among the arsenic workers than among the referents. There were positive correlations between cumulative exposure to arsenic, reduced NCV in three peripheral motor nerves, and decrease in FSP during cooling. Arsenic levels in urine were 1 ymole/1 (75 yg/1) in the arsenic workers and 0.1 ymole/1 in the referents. In 21 arsenic workers with no or very low exposure to vibra ting hand tools, the FSP during cooling had increased significantly after 3 years wit h the lower arsenic exposure. There was no change in FSP during the summer vacation, whereas urinary levels of arsenic decreased to normal values. Thus there seems to be a slow improvement of finger blood circ ulation which is independent of short-term fluctuations in the exposure to arsenic. No seasonal variation was found in FSP during cooling with the standardized method used. When the NCV-measurements were repeated five years later the difference between arsenic workers and referents had increased, despite the fact that 14 of the 47 arsenic workers had had no exposure to arsenic during the last 1-5 years. These observations indicate, that in subjects with long term exposure to arsenic, sub-clinical neuropathy is not reversible. Ten milligrams of Ketanserin, a serotonin receptor antagonist, was given intravenously to five arsenic workers with cold-induced vasospasm. Skin temperature and FSP during cooling increased significantly with Ketanserin as compared wit h saline solution. After oral treatment, 2 x 40 mg /day for four weeks, no significant increase of FSP during cooling or rise in skin temperature was found in six arsenic workers and eleven patients with Raynaud's phenomenon. The decrease of vasospastic tendency after intravenous injection of Ketanserin indicated that similar mechanisms might operate in arsenic-induced and other types of Raynaud's phenomenon. A general co nclusion from the five studies in this dissertation is that long-term occupational exposure to arsenic has had adverse effects on the peripheral circulation and nerve conduction. The tendency to vasospasm, but not the sub-clinical neuropathy, seemed to be reversible with decreasing exposure.S. 1-54: sammanfattning, s. 55-112: 5 uppsatserdigitalisering@um