The MROI fringe tracker: Laboratory tracking with ICONN

The loop is closed on ICONN, the Magdalena Ridge Observatory Interferometer fringe tracker. Results from laboratory experiments demonstrating ICONN's ability to track realistic, atmospheric-like path difference perturbations in real-time are shown. Characterizing and understanding the behavior and limits of ICONN in a controlled environment are key for reaching the goals of the MROI. The limiting factors in the experiments were found to be the light delivery system and temporary path length correction mechanism; not the on-sky components of ICONN. ICONN was capable of tracking fringes with a coherence loss below 5%; this will only improve in its final deployment.The Magdalena Ridge Observatory Interferometer is funded by the US Department of Transportation, the State of New Mexico, and New Mexico Tech with previous funding from the Navy Research Laboratory (NRL, agreement no. N00173-01-2-C902).This is the final version of the article, also available from SPIE at http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1891933. Copyright 2014 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.205560

A lack of evolution in the very bright-end of the galaxy luminosity function from z ≃ 8-10

We utilize deep near-infrared survey data from the UltraVISTA fourth data release (DR4) and the VIDEO survey, in combination with overlapping optical and Spitzer data, to search for bright star-forming galaxies at z ≳ 7.5. Using a full photometric redshift fitting analysis applied to the ∼6 deg2 of imaging searched, we find 27 Lyman break galaxies (LBGs), including 20 new sources, with best-fitting photometric redshifts in the range 7.4 5 data over a wide range in absolute UV magnitude (−23 < MUV < −17). We postulate that the observed evolution can be explained by a lack of mass quenching at very high redshifts in combination with increasing dust obscuration within the first ∼1Gyr of galaxy evolution

Chronic non-specific low back pain - sub-groups or a single mechanism?

Copyright 2008 Wand and O'Connell; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Background: Low back pain is a substantial health problem and has subsequently attracted a considerable amount of research. Clinical trials evaluating the efficacy of a variety of interventions for chronic non-specific low back pain indicate limited effectiveness for most commonly applied interventions and approaches. Discussion: Many clinicians challenge the results of clinical trials as they feel that this lack of effectiveness is at odds with their clinical experience of managing patients with back pain. A common explanation for this discrepancy is the perceived heterogeneity of patients with chronic non-specific low back pain. It is felt that the effects of treatment may be diluted by the application of a single intervention to a complex, heterogeneous group with diverse treatment needs. This argument presupposes that current treatment is effective when applied to the correct patient. An alternative perspective is that the clinical trials are correct and current treatments have limited efficacy. Preoccupation with sub-grouping may stifle engagement with this view and it is important that the sub-grouping paradigm is closely examined. This paper argues that there are numerous problems with the sub-grouping approach and that it may not be an important reason for the disappointing results of clinical trials. We propose instead that current treatment may be ineffective because it has been misdirected. Recent evidence that demonstrates changes within the brain in chronic low back pain sufferers raises the possibility that persistent back pain may be a problem of cortical reorganisation and degeneration. This perspective offers interesting insights into the chronic low back pain experience and suggests alternative models of intervention. Summary: The disappointing results of clinical research are commonly explained by the failure of researchers to adequately attend to sub-grouping of the chronic non-specific low back pain population. Alternatively, current approaches may be ineffective and clinicians and researchers may need to radically rethink the nature of the problem and how it should best be managed

The Magdalena Ridge Observatory Interferometer: 2014 status update

The Magdalena Ridge Observatory Interferometer has been designed to be a 10 × 1.4 m aperture long-baseline optical/near-infrared interferometer in an equilateral "Y" configuration, and is being deployed west of Socorro, NM on the Magdalena Ridge. Unfortunately, first light for the facility has been delayed due to the current difficult funding regime, but during the past two years we have made substantial progress on many of the key subsystems for the array. The design of all these subsystems is largely complete, and laboratory assembly and testing, and the installation and site acceptance testing of key components on the Ridge are now underway. This paper serves as an overview and update on the facility's present status and changes since 2012, and the plans for future activities and eventual operations of the facilities. © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.The Magdalena Ridge Observatory Interferometer is funded by the U.S. Department of Transportation, the State of New Mexico, and New Mexico Tech with previous funding from the Navy Research Laboratory (NRL, agreement no. N00173-01-2-C902).This is the final published version of the article, also available from SPIE at http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1891908. Copyright 2014 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.205733

Urinary levels of N-nitroso compounds in relation to risk of gastric cancer: Findings from the Shanghai cohort study

Background: N-Nitroso compounds are thought to play a significant role in the development of gastric cancer. Epidemiological data, however, are sparse in examining the associations between biomarkers of exposure to N-nitroso compounds and the risk of gastric cancer. Methods: A nested case-control study within a prospective cohort of 18,244 middle-aged and older men in Shanghai, China, was conducted to examine the association between urinary level of N-nitroso compounds and risk of gastric cancer. Information on demographics, usual dietary intake, and use of alcohol and tobacco was collected through in-person interviews at enrollment. Urinary levels of nitrate, nitrite, N-nitroso-2-methylthiazolidine-4-carboxylic acid (NMTCA), N-nitrosoproline (NPRO), N-nitrososarcosine (NSAR), N-nitrosothiazolidine-4-carboxylic acid (NTCA), as well as serum H. pylori antibodies were quantified in 191 gastric cancer cases and 569 individually matched controls. Logistic regression method was used to assess the association between urinary levels of N-nitroso compounds and risk of gastric cancer. Results: Compared with controls, gastric cancer patients had overall comparable levels of urinary nitrate, nitrite, and N-nitroso compounds. Among individuals seronegative for antibodies to H. pylori, elevated levels of urinary nitrate were associated with increased risk of gastric cancer. The multivariate-adjusted odds ratios for the second and third tertiles of nitrate were 3.27 (95% confidence interval = 0.76-14.04) and 4.82 (95% confidence interval = 1.05-22.17), respectively, compared with the lowest tertile (P for trend = 0.042). There was no statistically significant association between urinary levels of nitrite or N-nitroso compounds and risk of gastric cancer. Urinary NMTCA level was significantly associated with consumption of alcohol and preserved meat and fish food items. Conclusion: The present study demonstrates that exposure to nitrate, a precursor of N-nitroso compounds, may increase the risk of gastric cancer among individuals without a history of H. pylori infection

Making the best of both worlds: Can high-resolution agricultural administrative data support the assessment of High Nature Value farmlands across Europe?

Worldwide, the role of farmlands for biodiversity conservation and the delivery of multiple ecosystemservices has been widely acknowledged. In the European Union (EU), societal demands to include envi-ronmental conservation concerns within the Common Agricultural Policy (CAP) have resulted in therecognition of the importance of maintaining High Nature Value farmlands (HNVf).HNVf constitute complex social-ecological systems, which owe their nature conservation value to themaintenance of specific, mostly low-intensity farming systems, supporting high levels of species andhabitats dependent on agricultural practices. Even though HNVf assessment in space and time is essentialto evaluate the effectiveness of Rural Development Programmes, the diversity of rural landscapes acrossEU, the scarcity of data on farming systems, and the lack of common methodological guidelines hashampered the implementation of HNVf mapping and monitoring across Europe. Thus, there is a pressingneed to develop and test methodological approaches that may support HNVf assessment across the EU.The Integrated Administration and Control System (IACS) which is mandatory for all EU Member Statesconstitutes a system for the management and control of CAP payments to farmers. Essentially, IACS com-prises high-resolution, spatially explicit information on the type and intensity of agricultural land-use.Even though such data exhibits high thematic, spatial and temporal resolution, IACS has seldom beenused, due to significant access restrictions. Here, the potential to use IACS data to support the assessmentof HNVf was evaluated within the German Federal State of Lower Saxony by implementing a recentlydeveloped methodological framework. Sets of indicators known to be essential for identifying potentialHNVf and underlying farming systems (expressing landscape structure and composition, farming sys-tems, and crop diversity), were derived from IACS. Spatial patterns of indicators were analyzed at twodifferent scales to delineate the potential distribution of HNVf across Lower Saxony.Results highlighted that most regions in Lower Saxony were characterized by intensive farming prac-tices including high livestock density, high share of intensive crops and low density of linear elements.Only 3% of the Utilized Agricultural Area (UAA) of Lower Saxony potentially constituted HNVf, withthe majority of HNVf coinciding with mosaics of arable and/or permanent crops and semi-natural fea-tures under less intensive farming practices. Semi-natural grasslands, partially under agri-environmentscheme management contracts, covered roughly 1% of the UAA and were mostly intermingled with otherfarmland habitats in extensively managed agricultural landscapes

Towards an understanding of the information and support needs of surgical adolescent idiopathic scoliosis patients: a qualitative analysis

<p>Abstract</p> <p>Background</p> <p>Informed decision making for adolescents and families considering surgery for scoliosis requires essential information, including expected outcomes with or without treatment and the associated risks and benefits of treatment. Ideally families should also receive support in response to their individual concerns. The aim of this study was to identify health-specific needs for online information and support for patients with adolescent idiopathic scoliosis who have had or anticipate having spinal surgery.</p> <p>Methods</p> <p>Focus group methodology was chosen as the primary method of data collection to encourage shared understandings, as well as permit expression of specific, individual views. Participants were considered eligible to participate if they had either experienced or were anticipating surgery for adolescent idiopathic scoliosis within 12 months, were between the ages of 10 and 18 years of age, and were English-speaking.</p> <p>Results</p> <p>Two focus groups consisting of 8 adolescents (1 male, 7 female) and subsequent individual interviews with 3 adolescents (1 male, 2 female) yielded a range of participant concerns, in order of prominence: (1) recovery at home; (2) recovery in hospital; (3) post-surgical appearance; (4) emotional impact of surgery and coping; (5) intrusion of surgery and recovery of daily activities; (6) impact of surgery on school, peer relationships and other social interactions; (7) decision-making about surgery; (8) being in the operating room and; (9) future worries.</p> <p>Conclusion</p> <p>In conclusion, adolescents welcomed the possibility of an accessible, youth-focused website with comprehensive and accurate information that would include the opportunity for health professional-moderated, online peer support.</p

Can luteal regression be reversed?

The corpus luteum is an endocrine gland whose limited lifespan is hormonally programmed. This debate article summarizes findings of our research group that challenge the principle that the end of function of the corpus luteum or luteal regression, once triggered, cannot be reversed. Overturning luteal regression by pharmacological manipulations may be of critical significance in designing strategies to improve fertility efficacy

Child/Adolescent Anxiety Multimodal Study (CAMS): rationale, design, and methods

<p>Abstract</p> <p>Objective</p> <p>To present the design, methods, and rationale of the Child/Adolescent Anxiety Multimodal Study (CAMS), a recently completed federally-funded, multi-site, randomized placebo-controlled trial that examined the relative efficacy of cognitive-behavior therapy (CBT), sertraline (SRT), and their combination (COMB) against pill placebo (PBO) for the treatment of separation anxiety disorder (SAD), generalized anxiety disorder (GAD) and social phobia (SoP) in children and adolescents.</p> <p>Methods</p> <p>Following a brief review of the acute outcomes of the CAMS trial, as well as the psychosocial and pharmacologic treatment literature for pediatric anxiety disorders, the design and methods of the CAMS trial are described.</p> <p>Results</p> <p>CAMS was a six-year, six-site, randomized controlled trial. Four hundred eighty-eight (N = 488) children and adolescents (ages 7-17 years) with DSM-IV-TR diagnoses of SAD, GAD, or SoP were randomly assigned to one of four treatment conditions: CBT, SRT, COMB, or PBO. Assessments of anxiety symptoms, safety, and functional outcomes, as well as putative mediators and moderators of treatment response were completed in a multi-measure, multi-informant fashion. Manual-based therapies, trained clinicians and independent evaluators were used to ensure treatment and assessment fidelity. A multi-layered administrative structure with representation from all sites facilitated cross-site coordination of the entire trial, study protocols and quality assurance.</p> <p>Conclusions</p> <p>CAMS offers a model for clinical trials methods applicable to psychosocial and psychopharmacological comparative treatment trials by using state-of-the-art methods and rigorous cross-site quality controls. CAMS also provided a large-scale examination of the relative and combined efficacy and safety of the best evidenced-based psychosocial (CBT) and pharmacologic (SSRI) treatments to date for the most commonly occurring pediatric anxiety disorders. Primary and secondary results of CAMS will hold important implications for informing practice-relevant decisions regarding the initial treatment of youth with anxiety disorders.</p> <p>Trial registration</p> <p>ClinicalTrials.gov NCT00052078.</p