121 research outputs found
Oral bisphosphonate compliance and persistence: a matter of choice?
Compliance to oral bisphosphonates is suboptimal, with negative consequences of increased healthcare utilization and less effective fracture risk reduction. Extending dose interval increased adherence only moderately. We used literature derived from multiple chronic conditions to examine the problem of noncompliance with osteoporosis medication. We reviewed the literature on adherence to osteoporosis medication as well as that across multiple chronic conditions to understand what is known about the cause of the poor adherence. Poor compliance to oral medications is due mostly, not to forgetfulness, but to deliberate choice. Gender differences and style of healthcare management also play a role. Preliminary data suggest psychobehavioral interventions may help to improve motivation. We need to understand better reasons for poor compliance before effective interventions can be developed. Forgetfulness is only a small part of poor compliance. Patient preferences must be considered in medication decision making
Illegal immigration and media exposure: evidence on individual attitudes
Illegal immigration has been the focus of much debate in receiving countries, but little is known about the drivers of individual attitudes towards illegal immigrants. To study this question, we use the CCES survey, which was carried out in 2006 in the USA. We find evidence that—in addition to standard labor market and welfare state considerations—media exposure is significantly correlated with public opinion on illegal immigration. Controlling for education, income, ideology, and other socio-demographic characteristics, individuals watching Fox News are 9 percentage points more likely than CBS viewers to oppose the legalization of undocumented immigrants. We find an effect of the same size and direction for CNN viewers, whereas individuals watching PBS are instead more likely to support legalization. Ideological self-selection into different news programs plays an important role, but cannot entirely explain the correlation between media exposure and attitudes about illegal immigration
How does the media portray drinking water security in Indigenous communities in Canada? An analysis of Canadian newspaper coverage from 2000-2015
Awareness, concern and willingness to adopt biosecure behaviours: public perceptions of invasive tree pests and pathogens in the UK
The growing incidence of invasive tree
pest and disease outbreaks is recognised as an
increasing threat to ecosystem services and human
wellbeing. Linked to global trade, human movement
and climate change, a number of outbreaks have
attracted high public and media attention. However,
there is surprisingly little evidence characterising the
nature of public attentiveness to these events, nor how
publics might respond to evolving outbreaks and the
management actions taken. This paper presents findings
from an online questionnaire involving 1334
respondents nationally-representative of the British
public to assess awareness, concern and willingness to
adopt biosecure behaviours. Despite revealing low
levels of awareness and knowledge, the results indicate
that the British public is concerned about the
health of trees, forests and woodlands and is moderately
willing to adopt biosecure behaviours. A key
finding is that membership of environmental organisations
and strong place identity are likely to engender
higher awareness and levels of concern about tree
pests and diseases. Further, those who visit woodlands
regularly are likely to be more aware than non-visitors,
and gardeners are more likely to be concerned than
non-gardeners. Women, older respondents, those with
strong place identity and dependence, members of
environmental organisations, woodland visitors and
gardeners were most likely to express a willingness to
adopt biosecure behaviours. A comparison with findings
from a survey conducted by the authors 3 years
previously shows a decline over time in awareness,
concern and willingness
Communicative Dynamics and the Polyphony of Corporate Social Responsibility in the Network Society
Recent developments in immunotherapy of acute myeloid leukemia
The advent of new immunotherapeutic agents in clinical practice has revolutionized cancer treatment in the past decade, both in oncology and hematology. The transfer of the immunotherapeutic concepts to the treatment of acute myeloid leukemia (AML) is hampered by various characteristics of the disease, including non-leukemia-restricted target antigen expression profile, low endogenous immune responses, and intrinsic resistance mechanisms of the leukemic blasts against immune responses. However, considerable progress has been made in this field in the past few years. Within this manuscript, we review the recent developments and the current status of the five currently most prominent immunotherapeutic concepts: (1) antibody-drug conjugates, (2) T cell-recruiting antibody constructs, (3) chimeric antigen receptor (CAR) T cells, (4) checkpoint inhibitors, and (5) dendritic cell vaccination. We focus on the clinical data that has been published so far, both for newly diagnosed and refractory/relapsed AML, but omitting immunotherapeutic concepts in conjunction with hematopoietic stem cell transplantation. Besides, we have included important clinical trials that are currently running or have recently been completed but are still lacking full publication of their results. While each of the concepts has its particular merits and inherent problems, the field of immunotherapy of AML seems to have taken some significant steps forward. Results of currently running trials will reveal the direction of further development including approaches combining two or more of these concepts
Relationship Between Media Coverage and Measles-Mumps-Rubella (MMR) Vaccination Uptake in Denmark: Retrospective Study
Unusual migration profiles of Japanese encephalitis virus structural polypeptides in SDS-polyacrylamide gel electrophoresis
Remote sensing of terrestrial non-photosynthetic vegetation using hyperspectral, multispectral, SAR, and LiDAR data
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