12 research outputs found
A direct kinematical derivation of the relativistic Sagnac effect for light or matter beams
The Sagnac time delay and the corresponding Sagnac phase shift, for
relativistic matter and electromagnetic beams counter-propagating in a rotating
interferometer, are deduced on the ground of relativistic kinematics. This
purely kinematical approach allows to explain the ''universality'' of the
effect, namely the fact that the Sagnac time difference does not depend on the
physical nature of the interfering beams. The only prime requirement is that
the counter-propagating beams have the same velocity with respect to any
Einstein synchronized local co-moving inertial frame.Comment: 10 pages, 1 EPS figure, to appear in General Relativity and
Gravitatio
The Sagnac Phase Shift suggested by the Aharonov-Bohm effect for relativistic matter beams
The phase shift due to the Sagnac Effect, for relativistic matter beams
counter-propagating in a rotating interferometer, is deduced on the bases of a
a formal analogy with the the Aharonov-Bohm effect. A procedure outlined by
Sakurai, in which non relativistic quantum mechanics and newtonian physics
appear together with some intrinsically relativistic elements, is generalized
to a fully relativistic context, using the Cattaneo's splitting technique. This
approach leads to an exact derivation, in a self-consistently relativistic way,
of the Sagnac effect. Sakurai's result is recovered in the first order
approximation.Comment: 18 pages, LaTeX, 2 EPS figures. To appear in General Relativity and
Gravitatio
Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesBACKGROUND: In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE. METHODS: We obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC) inception cohort. This included 216 patients with NP events and two matched controls with SLE but no NP events for each of these patients. For the NP patients we tested samples taken before, during and after the NP event. RESULTS: Twenty-six patients had events attributed to SLE according to the most stringent SLICC attribution rule. In these patients there was no association between onset of event and elevated serum NN. In 190 patients in whom events were not attributed to SLE by the SLICC rules, median serum NN was elevated at the onset of event (P = 0.006). The predominant clinical features in this group of 190 patients were headache, mood disorders and anxiety. CONCLUSIONS: Serum NN levels rise at the time of an NP event in a proportion of patients with SLE. Further studies are needed to determine the value of serum NN as a biomarker for NPSLE.LUPUS UK
Rosetrees Trust
Arthritis Research UK Programme Grant
National Institute for Health Research (NIHR) University College London Hospitals Biomedical Research Centre
Canadian Institutes of Health Research
Hanyang University
Sandwell and West Birmingham Hospitals National Health Service (NHS) Trust
IHR/Wellcome Trust Clinical Research Facility in Birmingham
National Institutes of Health (NIH)
Singer Family Fund for Lupus Research
Arthritis Research UK
National Institute for Health Research Manchester Biomedical Research Unit
NIHR/Wellcome Trust Manchester Clinical Research Facility
Danish Rheumatism Association
Novo Nordisk Foundation
NIH
Department of Education, Universities and Research of the Basque Government
Arthritis Research U