Gears

Discussion GroupNew gear applications Rotordynamics Bearings for gear drives Installation questions Metallurgy/heat treat methods Contamination Overhaul frequency Instrumentation/Monitoring Lubrication Efficienc

Gears

Discussion Grou

Assessing the Likelihood of Rare Medical Events in Astronauts

Despite over half a century of manned space flight, the space flight community is only now coming to fully assess the short and long term medical dangers of exposure to reduced gravity environments. Further, as new manned spacecraft are designed and with the advent of commercial flight capabilities to the general public, a full understanding of medical risk becomes even more critical for maintaining and understanding mission safety and crew health. To address these critical issues, the National Aeronautics and Space Administration (NASA) Human Research Program (HRP) has begun to address the medical hazards with a formalized risk management approach by effectively identifying and attempting to mitigate acute and chronic medical risks to manned space flight. This paper describes NASA Glenn Research Center?s (GRC) efforts to develop a systematic methodology to assess the likelihood of in-flight medical conditions. Using a probabilistic approach, medical risks are assessed using well established and accepted biomedical and human performance models in combination with fundamentally observed data that defines the astronauts? physical conditions, environment and activity levels. Two different examples of space flight risk are used to show the versatility of our approach and how it successfully integrates disparate information to provide HRP decision makers with a valuable source of information which is otherwise lacking

Gears

Discussion GroupNew gear applications Rotordynamics Bearings for gear drives Installation questions Metallurgy/heat treat methods Contamination Overhaul frequency Instrumentation/Monitoring Lubrication Efficienc

Estimated Probabililty of Chest Injury During an International Space Station Mission

The Integrated Medical Model (IMM) is a decision support tool that is useful to spaceflight mission planners and medical system designers when assessing risks and optimizing medical systems. The IMM project maintains a database of medical conditions that could occur during a spaceflight. The IMM project is in the process of assigning an incidence rate, the associated functional impairment, and a best and a worst case end state for each condition. The purpose of this work was to develop the IMM Chest Injury Module (CIM). The CIM calculates the incidence rate of chest injury per person-year of spaceflight on the International Space Station (ISS). The CIM was built so that the probability of chest injury during one year on ISS could be predicted. These results will be incorporated into the IMM Chest Injury Clinical Finding Form and used within the parent IMM model

A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recordOBJECTIVE: To evaluate for the first time the effects of a combination of sage, rosemary and melissa (Salvia officinalis L., Rosmarinus officinalis L. and Melissa officinalis L.; SRM), traditional European medicines, on verbal recall in normal healthy subjects. To devise a suitable study design for assessing the clinical efficacy of traditional herbal medicines for memory and brain function. METHODS: Forty-four normal healthy subjects (mean age 61 ± 9.26y SD; m/f 6/38) participated in this study. A double-blind, randomised, placebo-controlled pilot study was performed with subjects randomised into an active and placebo group. The study consisted of a single 2-week term ethanol extract of SRM that was chemically-characterised using high resolution LC-UV-MS/MS analysis. Immediate and delayed word recall were used to assess memory after taking SRM or placebo (ethanol extract of Myrrhis odorata (L.) Scop.). In addition analysis was performed with subjects divided into younger and older subgroups (≤ 62 years mean age n = 26: SRM n = 10, Placebo n = 16; ≥ 63 years n = 19: SRM n = 13, Placebo n = 6). RESULTS: Overall there were no significant differences between treatment and placebo change from baseline for immediate or delayed word recall. However subgroup analysis showed significant improvements to delayed word recall in the under 63 year age group (p < 0.0123) with Cohen's effect size d = 0.92. No adverse effects were observed. CONCLUSION: This pilot study indicates that an oral preparation of SRM at the selected dose and for the period of administration is more effective than a placebo in supported verbal episodic memory in healthy subjects under 63 years of age. Short- and long- term supplementation with SRM extract merits more robust investigation as an adjunctive treatment for patients with Alzheimer's disease and in the general ageing population. The study design proved a simple cost effective trial protocol to test the efficacy of herbal medicines on verbal episodic memory, with future studies including broader cognitive assessment.Support by the following organisations is gratefully acknowledged, Ross Menzies Herbal Clinic, Bodyworks Therapy Centre; Wesnes Cognition Ltd, the Royal Botanic Gardens (RBG), Kew and Dilston Physic Garden. The phytochemical analysis was gratefully funded by the Sir Jeremiah Colman Gift Trust

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Low-Temperature Spin Diffusion in a Spin-Polarized Fermi Gas

We present a finite temperature calculation of the transverse spin-diffusion coefficient, $D_\bot$, in a dilute degenerate Fermi gas in the presence of a small external magnetic field, $H$. While the longitudinal diffusion coefficient displays the conventional low-temperature Fermi-liquid behavior, $D_\parallel \propto T^{-2}$, the corresponding results for $D_\bot$ show three separate regimes: (a) $D_\bot \sim H^{-2}$ for $T \ll H$; (b) $D_\bot \sim T^{-2}$, $D_\bot /D_\parallel \neq 1$ for $T \gg H$ and large spin-rotation parameter $\xi \gg 1$, and (c) $D_\bot = D_\parallel \propto T^{-2}$ for $T \gg H$ and $\xi \ll 1$. Our results are qualitatively consistent with the available experimental data in weakly spin-polarized $^3{\rm He}$ and $^3{\rm He} - ^4{\rm He}$ mixtures.Comment: 13 pages, REVTEX, 3 figures available upon request, RU-94-4

A new hammer to crack an old nut : interspecific competitive resource capture by plants is regulated by nutrient supply, not climate

Peer reviewedPublisher PD