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    Mean Li-Yorke chaos in Banach spaces

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    We investigate the notion of mean Li-Yorke chaos for operators on Banach spaces. We show that it differs from the notion of distributional chaos of type 2, contrary to what happens in the context of topological dynamics on compact metric spaces. We prove that an operator is mean Li-Yorke chaotic if and only if it has an absolutely mean irregular vector. As a consequence, absolutely Ces\`aro bounded operators are never mean Li-Yorke chaotic. Dense mean Li-Yorke chaos is shown to be equivalent to the existence of a dense (or residual) set of absolutely mean irregular vectors. As a consequence, every mean Li-Yorke chaotic operator is densely mean Li-Yorke chaotic on some infinite-dimensional closed invariant subspace. A (Dense) Mean Li-Yorke Chaos Criterion and a sufficient condition for the existence of a dense absolutely mean irregular manifold are also obtained. Moreover, we construct an example of an invertible hypercyclic operator TT such that every nonzero vector is absolutely mean irregular for both TT and T−1T^{-1}. Several other examples are also presented. Finally, mean Li-Yorke chaos is also investigated for C0C_0-semigroups of operators on Banach spaces.Comment: 26 page

    Mean Li-Yorke chaos in Banach spaces

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    [EN] We investigate the notion of mean Li-Yorke chaos for operators on Banach spaces. We show that it differs from the notion of distributional chaos of type 2, contrary to what happens in the context of topological dynamics on compact metric spaces. We prove that an operator is mean Li-Yorke chaotic if and only if it has an absolutely mean irregular vector. As a consequence, absolutely Cesaro bounded operators are never mean Li-Yorke chaotic. Dense mean Li-Yorke chaos is shown to be equivalent to the existence of a dense (or residual) set of absolutely mean irregular vectors. As a consequence, every mean Li-Yorke chaotic operator is densely mean Li-Yorke chaotic on some infinite-dimensional closed invariant subspace. A (Dense) Mean Li-Yorke Chaos Criterion and a sufficient condition for the existence of a dense absolutely mean irregular manifold are also obtained. Moreover, we construct an example of an invertible hypercyclic operator T such that every nonzero vector is absolutely mean irregular for both T and T-1. Several other examples are also presented. Finally, mean Li-Yorke chaos is also investigated for C-0-semigroups of operators on Banach spaces.This work was partially done on a visit of the first author to the Institut Universitari de Matematica Pura i Aplicada at Universitat Politecnica de Valencia, and he is very grateful for the hospitality and support. The first author was partially supported by project #304207/2018-7 of CNPq and by grant #2017/22588-0 of Sao Paulo Research Foundation (FAPESP). The second and third authors were supported by MINECO, Project MTM2016-75963-P. The third author was also supported by Generalitat Valenciana, Project PROMETEO/2017/102. We thank Frederic Bayart for providing us Theorem 27, which answers a previous question of us. We also thank the referee whose careful comments produced an improvement in the presentation of the article.Bernardes, NCJ.; Bonilla, A.; Peris Manguillot, A. (2020). Mean Li-Yorke chaos in Banach spaces. Journal of Functional Analysis. 278(3):1-31. https://doi.org/10.1016/j.jfa.2019.108343S1312783Albanese, A., Barrachina, X., Mangino, E. M., & Peris, A. (2013). Distributional chaos for strongly continuous semigroups of operators. Communications on Pure and Applied Analysis, 12(5), 2069-2082. doi:10.3934/cpaa.2013.12.2069Barrachina, X., & Conejero, J. A. (2012). Devaney Chaos and Distributional Chaos in the Solution of Certain Partial Differential Equations. Abstract and Applied Analysis, 2012, 1-11. doi:10.1155/2012/457019Barrachina, X., & Peris, A. (2012). Distributionally chaotic translation semigroups. Journal of Difference Equations and Applications, 18(4), 751-761. doi:10.1080/10236198.2011.625945Bayart, F., & Grivaux, S. (2006). Frequently hypercyclic operators. 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Li–Yorke chaos in linear dynamics. Ergodic Theory and Dynamical Systems, 35(6), 1723-1745. doi:10.1017/etds.2014.20Bernardes, N. C., Peris, A., & Rodenas, F. (2017). Set-Valued Chaos in Linear Dynamics. Integral Equations and Operator Theory, 88(4), 451-463. doi:10.1007/s00020-017-2394-6Bernardes, N. C., Bonilla, A., Peris, A., & Wu, X. (2018). Distributional chaos for operators on Banach spaces. Journal of Mathematical Analysis and Applications, 459(2), 797-821. doi:10.1016/j.jmaa.2017.11.005Bès, J., Menet, Q., Peris, A., & Puig, Y. (2015). Recurrence properties of hypercyclic operators. Mathematische Annalen, 366(1-2), 545-572. doi:10.1007/s00208-015-1336-3Conejero, J. A., Müller, V., & Peris, A. (2007). Hypercyclic behaviour of operators in a hypercyclic C0-semigroup. Journal of Functional Analysis, 244(1), 342-348. doi:10.1016/j.jfa.2006.12.008Alberto Conejero, J., Rodenas, F., & Trujillo, M. (2015). Chaos for the Hyperbolic Bioheat Equation. Discrete & Continuous Dynamical Systems - A, 35(2), 653-668. doi:10.3934/dcds.2015.35.653Downarowicz, T. (2013). Positive topological entropy implies chaos DC2. Proceedings of the American Mathematical Society, 142(1), 137-149. doi:10.1090/s0002-9939-2013-11717-xFeldman, N. S. (2002). Hypercyclicity and supercyclicity for invertible bilateral weighted shifts. Proceedings of the American Mathematical Society, 131(2), 479-485. doi:10.1090/s0002-9939-02-06537-1Foryś-Krawiec, M., Oprocha, P., & Štefánková, M. (2017). Distributionally chaotic systems of type 2 and rigidity. Journal of Mathematical Analysis and Applications, 452(1), 659-672. doi:10.1016/j.jmaa.2017.02.056Garcia-Ramos, F., & Jin, L. (2016). Mean proximality and mean Li-Yorke chaos. Proceedings of the American Mathematical Society, 145(7), 2959-2969. doi:10.1090/proc/13440Grivaux, S., & Matheron, É. (2014). Invariant measures for frequently hypercyclic operators. 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    Traditional vs Machine Learning Approaches: A Comparison of Time Series Modeling Methods

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    In recent years, various new Machine Learning and Deep Learning algorithms have been introduced, claiming to offer better performance than traditional statistical approaches when forecasting time series. Studies seeking evidence to support the usage of ML/DL over statistical approaches have been limited to comparing the forecasting performance of univariate, linear time series data. This research compares the performance of traditional statistical-based and ML/DL methods for forecasting multivariate and nonlinear time series

    Generation of periventricular reactive astrocytes overexpressing aquaporin 4 is stimulated by mesenchymal stem cell therapy

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    Aquaporin-4 (AQP4) plays a crucial role in brain water circulation and is considered a therapeutic target in hydrocephalus. Congenital hydrocephalus is associated with a reaction of astrocytes in the periventricular white matter both in experimental models and human cases. A previous report showed that bone marrow-derived mesenchymal stem cells (BM-MSCs) transplanted into the lateral ventricles of hyh mice exhibiting severe congenital hydrocephalus are attracted by the periventricular astrocyte reaction, and the cerebral tissue displays recovery. The present investigation aimed to test the effect of BM-MSC treatment on astrocyte reaction formation. BM-MSCs were injected into the lateral ventricles of four-day-old hyh mice, and the periventricular reaction was detected two weeks later. A protein expression analysis of the cerebral tissue differentiated the BM-MSC-treated mice from the controls and revealed effects on neural development. In in vivo and in vitro experiments, BM-MSCs stimulated the generation of periventricular reactive astrocytes overexpressing AQP4 and its regulatory protein kinase D-interacting substrate of 220 kDa (Kidins220). In the cerebral tissue, mRNA overexpression of nerve growth factor (NGF), vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1 (HIF1α), and transforming growth factor beta 1 (TGFβ1) could be related to the regulation of the astrocyte reaction and AQP4 expression. In conclusion, BM-MSC treatment in hydrocephalus can stimulate a key developmental process such as the periventricular astrocyte reaction, where AQP4 overexpression could be implicated in tissue recovery

    The Application of Peptide Nucleic Acid Probes for Rapid Detection and Enumeration of Eubacteria, Staphylococcus aureus and Pseudomonas aeruginosa in Recreational Beaches of S. Florida

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    A novel chemiluminescent in situ hybridization technique using peptide nucleic acids (PNA) was adapted for the detection of bacteria in beach sand and recreational waters in South Florida. The simultaneous detection and enumeration of eubacteria and the novel indicators, Staphylococcus aureus and Pseudomonas aeruginosa, was achieved within 6–8 h of processing. Following 5 h of incubation on TSA, soybean peroxidase-labeled peptide nucleic acid probes (Boston Probes, Boston, MA) targeting species-specific 16S rRNA sequences of P. aeruginosa and S. aureus were used to hybridize microcolonies of the target species in-situ. In addition, a universal probe for 16S rRNA sequences was used to target the eubacteria. Probes were detected after a light generating reaction with a chemiluminescent substrate and their presence recorded on Polaroid film. The probes showed limited cross-reactivity with mixed indigenous bacteria extracted from seawater and sand by shaking with phosphate-buffered saline (PBS). Specificity and cross-reactivity was tested on the reference bacterial genera Pseudomonas, Staphylococcus,Vibrio, Shigella, Salmonella, Acinetobacter, Enterobacter, Escherichia and Citrobacter. These tests confirmed that the probes were specific for the microorganisms of interest and were unaffected by high salt levels. The results of the PNA chemiluminescent in situ hybridization were compared with traditional plate count methods (PCM) for total ‘freshwater’ eubacteria, S. aureus and P. aeruginosa. Counts of eubacteria and S. aureus were comparable with numbers obtained from traditional plate counts but levels of P. aeruginosa were higher with PNA than with PCM. It is possible that PNA is more sensitive than PCM because it can detect microcolonies on the agar surface that never fully develop with the plate count method. We conclude that the in situ hybridization technique used here represents an important potential tool for the rapid monitoring of novel indicator organisms in beaches and recreational waters

    The primary structure of three hemoglobin chains from the indigo snake (Drymarchon corais erebennus, Serpentes): First evidence for αD chains and two β chain types in snakes

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    The hemoglobin of the indigo snake (Drymarchon corais erebennus, Colubrinae) consists of two components, HbA and HbD, in the ratio of 1:1. They differ in both their alpha and beta chains. The amino acid sequences of both alpha chains (alpha(A) and alpha(D)) and one beta chain (betaI) were determined. The presence of an alpha(D)chain in a snake hemoglobin is described for the first time. A comparison of all snake beta chain sequences revealed the existence of two paralogous beta chain types in snakes as well, which are designated as betaI and betaII type. For the discussion of the physiological properties of Drymarchon hemoglobin, the sequences were compared with those of the human alpha and beta chains and those of the closely related water snake Liophis miliaris where functional data are available. Among the heme contacts, the substitution alpha(D)58(E7)His-->Gln is unusual but most likely without any effect. The residues responsible for the main part of the Bohr effect are the same as in mammalian hemoglobins. In each of the three globin chains only two residues at positions involved in the alpha1/beta2 interface contacts, most important for the stability and the properties of the hemoglobin molecule, are substituted with regard to human hemoglobin. On the contrary, nine, eleven, and six alpha1/beta1 contact residues are replaced in the alpha(A), alpha(D), betaI chains, respectively

    High Numbers of Staphylococcus aureus at Three Bathing Beaches in South Florida

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    While the value of Staphylococcus aureus as an indicator for non-enteric diseases is unclear, understanding its prevalence in recreational beaches would prove useful, given its pathogenic potential. Staphylococcus aureus levels were evaluated in sand and seawater at three beaches during one year. To elucidate possible S. aureussources or colonization trends, distribution in sand was analyzed at Hollywood Beach. Staphylococcus aureus levels fluctuated throughout the study with highest average densities detected in dry sand (3.46 × 105 CFU/g, Hobie Beach), particularly at beaches with high human density. Patchy distribution marked hotspots of human use and/or possible bacterial re-growth. Data from a brief epidemiological survey indicated a very slight association between beach usage and skin conditions; suggesting high S. aureus levels in sand may not necessarily constitute major health risks. Because the possibility of disease transmission exists, particularly to children and immuno-compromised beach-goers, periodic surveying of highly frequented beaches seems warranted

    Genomic signatures of pre-resistance in Mycobacterium tuberculosis

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    Recent advances in bacterial whole-genome sequencing have resulted in a comprehensive catalog of antibiotic resistance genomic signatures in Mycobacterium tuberculosis. With a view to pre-empt the emergence of resistance, we hypothesized that pre-existing polymorphisms in susceptible genotypes (pre-resistance mutations) could increase the risk of becoming resistant in the future. We sequenced whole genomes from 3135 isolates sampled over a 17-year period. After reconstructing ancestral genomes on time-calibrated phylogenetic trees, we developed and applied a genome-wide survival analysis to determine the hazard of resistance acquisition. We demonstrate that M. tuberculosis lineage 2 has a higher risk of acquiring resistance than lineage 4, and estimate a higher hazard of rifampicin resistance evolution following isoniazid mono-resistance. Furthermore, we describe loci and genomic polymorphisms associated with a higher risk of resistance acquisition. Identifying markers of future antibiotic resistance could enable targeted therapy to prevent resistance emergence in M. tuberculosis and other pathogens
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