880 research outputs found
D-branes with Lorentzian signature in the Nappi-Witten model
Lorentzian signature D-branes of all dimensions for the Nappi-Witten string
are constructed. This is done by rewriting the gluing condition for
the model chiral currents on the brane as a well posed first order differential
problem and by solving it for Lie algebra isometries other than Lie algebra
automorphisms. By construction, these D-branes are not twined conjugacy
classes. Metrically degenerate D-branes are also obtained.Comment: 22 page
Hidden Yangian symmetry in sigma model on squashed sphere
We discuss a hidden symmetry of a two-dimensional sigma model on a squashed
S^3. The SU(2) current can be improved so that it can be regarded as a flat
connection. Then we can obtain an infinite number of conserved non-local
charges and show the Yangian algebra by directly checking the Serre relation.
This symmetry is also deduced from the coset structure of the squashed sphere.
The same argument is applicable to the warped AdS_3 spaces via double Wick
rotations.Comment: 11 pages, 1 figure, typos corrected, references adde
Geometric construction of D-branes in WZW models
The geometric description of D-branes in WZW models is pushed forward. Our
starting point is a gluing condition\, that matches the model's
chiral currents at the worldsheet boundary through a linear map acting on
the WZW Lie algebra. The equivalence of boundary and gluing conditions of this
type is studied in detail. The analysis involves a thorough discussion of
Frobenius integrability, shows that must be an isometry, and applies to
both metrically degenerate and nondegenerate D-branes. The isometry need
not be a Lie algebra automorphism nor constantly defined over the brane. This
approach, when applied to isometries of the form with a constant Lie
algebra automorphism, validates metrically degenerate -twined conjugacy
classes as D-branes. It also shows that no D-branes exist in semisimple WZW
models for constant\, .Comment: 23 pages, discussion of limitations of the gluing condition approach
adde
Galilean quantum gravity with cosmological constant and the extended q-Heisenberg algebra
We define a theory of Galilean gravity in 2+1 dimensions with cosmological
constant as a Chern-Simons gauge theory of the doubly-extended Newton-Hooke
group, extending our previous study of classical and quantum gravity in 2+1
dimensions in the Galilean limit. We exhibit an r-matrix which is compatible
with our Chern-Simons action (in a sense to be defined) and show that the
associated bi-algebra structure of the Newton-Hooke Lie algebra is that of the
classical double of the extended Heisenberg algebra. We deduce that, in the
quantisation of the theory according to the combinatorial quantisation
programme, much of the quantum theory is determined by the quantum double of
the extended q-deformed Heisenberg algebra.Comment: 22 page
Quantized Nambu-Poisson Manifolds in a 3-Lie Algebra Reduced Model
We consider dimensional reduction of the Bagger-Lambert-Gustavsson theory to
a zero-dimensional 3-Lie algebra model and construct various stable solutions
corresponding to quantized Nambu-Poisson manifolds. A recently proposed Higgs
mechanism reduces this model to the IKKT matrix model. We find that in the
strong coupling limit, our solutions correspond to ordinary noncommutative
spaces arising as stable solutions in the IKKT model with D-brane backgrounds.
In particular, this happens for S^3, R^3 and five-dimensional Neveu-Schwarz
Hpp-waves. We expand our model around these backgrounds and find effective
noncommutative field theories with complicated interactions involving
higher-derivative terms. We also describe the relation of our reduced model to
a cubic supermatrix model based on an osp(1|32) supersymmetry algebra.Comment: 22 page
Prompt Decays of General Neutralino NLSPs at the Tevatron
Recent theoretical developments have shown that gauge mediation has a much
larger parameter space of possible spectra and mixings than previously
considered. Motivated by this, we explore the collider phenomenology of gauge
mediation models where a general neutralino is the lightest MSSM superpartner
(the NLSP), focusing on the potential reach from existing and future Tevatron
searches. Promptly decaying general neutralino NLSPs can give rise to final
states involving missing energy plus photons, Zs, Ws and/or Higgses. We survey
the final states and determine those where the Tevatron should have the most
sensitivity. We then estimate the reach of existing Tevatron searches in these
final states and discuss new searches (or optimizations of existing ones) that
should improve the reach. Finally we comment on the potential for discovery at
the LHC.Comment: 41 pages, minor changes, added refs and discussion of previous
literatur
Integrated Expression of Circulating miR375 and miR371 to Identify Teratoma and Active Germ Cell Malignancy Components in Malignant Germ Cell Tumors
Active germ cell malignancies express high levels of specific circulating micro-RNAs (miRNAs), including miR-371a-3p (miR371), which is undetectable in teratoma. Teratoma markers are urgently needed for theselection of patients and treatments because of the risk of malignant transformation and growing teratoma syndrome. To assess the accuracy of plasma miR375 alone or in combination with miR371 in detecting teratoma, 100 germ cell tumor patients, divided into two cohorts, were enrolled in a prospective multi-institutional study. In the discovery cohort, patients with pure teratoma and with no/low risk of harboring teratoma were compared; the validation cohort included patients with confirmed teratoma, active germ cell malignancy, or complete response after chemotherapy. The area under the receiver operating characteristic curve values for miR375, miR371, and miR371-miR375 were, respectively, 0.93 (95% confidence interval [CI]: 0.87-0.99), 0.59 (95% CI: 0.44-0.73), and 0.95 (95% CI: 0.90-0.99) in the discovery cohort and 0.55 (95% CI: 0.36-0.74), 0.74 (95% CI: 0.58-0.91), and 0.77 (95% CI: 0.62-0.93) in the validation cohort. Our study demonstrated that the plasma miR371-miR375 integrated evaluation is highly accurate to detect teratoma. PATIENT SUMMARY: The evaluation of two micro-RNAs (miR375-miR371) in the blood of patients with germ cell tumors is promising to predict teratoma. This test could be particularly relevant to the identification of teratoma in patients with postchemotherapy residual disease.info:eu-repo/semantics/publishedVersio
Lack of phenotypic and evolutionary cross-resistance against parasitoids and pathogens in Drosophila melanogaster
BackgroundWhen organisms are attacked by multiple natural enemies, the evolution of a resistance mechanism to one natural enemy will be influenced by the degree of cross-resistance to another natural enemy. Cross-resistance can be positive, when a resistance mechanism against one natural enemy also offers resistance to another; or negative, in the form of a trade-off, when an increase in resistance against one natural enemy results in a decrease in resistance against another. Using Drosophila melanogaster, an important model system for the evolution of invertebrate immunity, we test for the existence of cross-resistance against parasites and pathogens, at both a phenotypic and evolutionary level.MethodsWe used a field strain of D. melanogaster to test whether surviving parasitism by the parasitoid Asobara tabida has an effect on the resistance against Beauveria bassiana, an entomopathogenic fungus; and whether infection with the microsporidian Tubulinosema kingi has an effect on the resistance against A. tabida. We used lines selected for increased resistance to A. tabida to test whether increased parasitoid resistance has an effect on resistance against B. bassiana and T. kingi. We used lines selected for increased tolerance against B. bassiana to test whether increased fungal resistance has an effect on resistance against A. tabida.Results/ConclusionsWe found no positive cross-resistance or trade-offs in the resistance to parasites and pathogens. This is an important finding, given the use of D. melanogaster as a model system for the evolution of invertebrate immunity. The lack of any cross-resistance to parasites and pathogens, at both the phenotypic and the evolutionary level, suggests that evolution of resistance against one class of natural enemies is largely independent of evolution of resistance against the other
Headache and migraine during pregnancy and puerperium: the MIGRA-study
There is little prospectively gathered data on the course of headaches during pregnancy and postpartum, and the influence of breastfeeding is unclear. This is a large, prospective study, which invited all pregnant women in the catchment area during a defined period. All participants (n = 2,126) filled in questionnaires concerning headache. Among these, a total of 208 women with migraine according to the International Headache Society criteria also filled in detailed headache diaries during pregnancy and the puerperal period. Freedom from earlier headaches during pregnancy was significantly more common than new onset of headache during pregnancy (p < 0.001). This was not influenced by prior use of oral contraceptives. According to the diaries, there was a gradual decrease during pregnancy in the frequency of all headaches and of self-considered migraine. There was also a significant decrease in the duration of headaches (p < 0.001) during pregnancy compared to before. Earlier parity did not influence the course. Apart from a significant increase during the first week postpartum (p < 0.01), the overall occurrence of headaches during puerperium did not differ from the pregnancy period. Compared to pregnancy, there was a postpartum increase in the mean intensity (p < 0.01) and duration (p = 0.050) of headaches, as well as in the mean number of analgesics used (p < 0.001). Breastfeeding did not influence the occurrence of headaches postpartum. These data are of practical value for informing pregnant migraineurs about the typical clinical prospects and for giving advice on breastfeeding
Beyond the standard seesaw: neutrino masses from Kahler operators and broken supersymmetry
We investigate supersymmetric scenarios in which neutrino masses are
generated by effective d=6 operators in the Kahler potential, rather than by
the standard d=5 superpotential operator. First, we discuss some general
features of such effective operators, also including SUSY-breaking insertions,
and compute the relevant renormalization group equations. Contributions to
neutrino masses arise at low energy both at the tree level and through finite
threshold corrections. In the second part we present simple explicit
realizations in which those Kahler operators arise by integrating out heavy
SU(2)_W triplets, as in the type II seesaw. Distinct scenarios emerge,
depending on the mechanism and the scale of SUSY-breaking mediation. In
particular, we propose an appealing and economical picture in which the heavy
seesaw mediators are also messengers of SUSY breaking. In this case, strong
correlations exist among neutrino parameters, sparticle and Higgs masses, as
well as lepton flavour violating processes. Hence, this scenario can be tested
at high-energy colliders, such as the LHC, and at lower energy experiments that
measure neutrino parameters or search for rare lepton decays.Comment: LaTeX, 34 pages; some corrections in Section
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