Evolution of Game Controllers: Toward the Support of Gamers with Physical Disabilities

Video games, as an entertaining media, dates back to the \u201850s and their hardware device underwent a long evolution starting from hand-made devices such as the \u201ccathode-ray tube amusement device\u201d up to the modern mass-produced consoles. This evolution has, of course, been accompanied by increasingly specialized interaction mechanisms. As of today, interaction with games is usually performed through industry-standard devices. These devices can be either general purpose (e.g., mouse and keyboard) or specific for gaming (e.g., a gamepad). Unfortunately, for marketing reasons, gaming interaction devices are not usually designed taking into consideration the requirements of gamers with physical disabilities. In this paper, we will offer a review of the evolution of gaming control devices with a specific attention to their use by players with physical disabilities in the upper limbs. After discussing the functionalities introduced by controllers designed for disabled players we will also propose an innovative game controller device. The proposed game controller is built around a touch screen interface which can be configured based on the user needs and will be accessible by gamers which are missing fingers or are lacking control in hands movement

Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells

The proto-oncogenic protein c-Myb is an essential regulator of hematopoiesis and is frequently deregulated in hematological diseases such as lymphoma and leukemia. To gain insight into the mechanisms underlying the aberrant expression of c-Myb in myeloid leukemia, we analyzed and compared c-myb gene transcriptional regulation using two cell lines modeling normal hematopoietic progenitor cells (HPCs) and transformed myelomonocytic blasts. We report that the transcription factors HoxA9, Meis1, Pbx1 and Pbx2 bind in vivo to the c-myb locus and maintain its expression through different mechanisms in HPCs and leukemic cells. Our analysis also points to a critical role for Pbx2 in deregulating c-myb expression in murine myeloid cells cotransformed by the cooperative activity of HoxA9 and Meis1. This effect is associated with an intronic positioning of epigenetic marks and RNA polymerase II binding in the orthologous region of a previously described alternative promoter for c-myb. Taken together, our results could provide a first hint to explain the abnormal expression of c-myb in leukemic cells

Building connectomes using diffusion MRI: why, how and but

Why has diffusion MRI become a principal modality for mapping connectomes in vivo? How do different image acquisition parameters, fiber tracking algorithms and other methodological choices affect connectome estimation? What are the main factors that dictate the success and failure of connectome reconstruction? These are some of the key questions that we aim to address in this review. We provide an overview of the key methods that can be used to estimate the nodes and edges of macroscale connectomes, and we discuss open problems and inherent limitations. We argue that diffusion MRI-based connectome mapping methods are still in their infancy and caution against blind application of deep white matter tractography due to the challenges inherent to connectome reconstruction. We review a number of studies that provide evidence of useful microstructural and network properties that can be extracted in various independent and biologically-relevant contexts. Finally, we highlight some of the key deficiencies of current macroscale connectome mapping methodologies and motivate future developments