1,166 research outputs found
Single-stranded genomic architecture constrains optimal codon usage
Viral codon usage is shaped by the conflicting forces of mutational pressure and selection to match host patterns for optimal expression. We examined whether genomic architecture (single- or double-stranded DNA) influences the degree to which bacteriophage codon usage differ from their primary bacterial hosts and each other. While both correlated equally with their hosts' genomic nucleotide content, the coat genes of ssDNA phages were less well adapted than those of dsDNA phages to their hosts' codon usage profiles due to their preference for codons ending in thymine. No specific biases were detected in dsDNA phage genomes. In all nine of ten cases of codon redundancy in which a specific codon was overrepresented, ssDNA phages favored the NNT codon. A cytosine to thymine biased mutational pressure working in conjunction with strong selection against non-synonymous mutations appears be shaping codon usage bias in ssDNA viral genomes
An avalanche-photodiode-based photon-number-resolving detector
Avalanche photodiodes are widely used as practical detectors of single
photons.1 Although conventional devices respond to one or more photons, they
cannot resolve the number in the incident pulse or short time interval.
However, such photon number resolving detectors are urgently needed for
applications in quantum computing,2-4 communications5 and interferometry,6 as
well as for extending the applicability of quantum detection generally. Here we
show that, contrary to current belief,3,4 avalanche photodiodes are capable of
detecting photon number, using a technique to measure very weak avalanches at
the early stage of their development. Under such conditions the output signal
from the avalanche photodiode is proportional to the number of photons in the
incident pulse. As a compact, mass-manufactured device, operating without
cryogens and at telecom wavelengths, it offers a practical solution for photon
number detection.Comment: 12 pages, 4 figure
ASASSN-18di: discovery of a flare on a mid-M dwarf
We report and characterize a white-light superflare on a previously undiscovered M dwarf detected by the ASAS-SN survey. Employing various color-magnitude and color-spectral type relationships, we estimate several stellar parameters, including the quiescent V-band magnitude, from which we derive a flare amplitude of . We determine an r-band absolute magnitude of , consistent with a mid-M dwarf, and an approximate distance to the source of kpc. Using classical-flare models, we infer a flare energy of ergs, making this one of the strongest flares documented on an M dwarf
Determinants of translation efficiency and accuracy
A given protein sequence can be encoded by an astronomical number of alternative nucleotide sequences. Recent research has revealed that this flexibility provides evolution with multiple ways to tune the efficiency and fidelity of protein translation and folding
On-demand semiconductor single-photon source with near-unity indistinguishability
Single photon sources based on semiconductor quantum dots offer distinct
advantages for quantum information, including a scalable solid-state platform,
ultrabrightness, and interconnectivity with matter qubits. A key prerequisite
for their use in optical quantum computing and solid-state networks is a high
level of efficiency and indistinguishability. Pulsed resonance fluorescence
(RF) has been anticipated as the optimum condition for the deterministic
generation of high-quality photons with vanishing effects of dephasing. Here,
we generate pulsed RF single photons on demand from a single,
microcavity-embedded quantum dot under s-shell excitation with 3-ps laser
pulses. The pi-pulse excited RF photons have less than 0.3% background
contributions and a vanishing two-photon emission probability.
Non-postselective Hong-Ou-Mandel interference between two successively emitted
photons is observed with a visibility of 0.97(2), comparable to trapped atoms
and ions. Two single photons are further used to implement a high-fidelity
quantum controlled-NOT gate.Comment: 11 pages, 11 figure
Improving the prediction of scour around submarine pipelines
YesLocal scour around submarine pipelines can affect the stability of the pipeline. The accurate estimation of the scour around submarine pipelines has been a hot topic of research among marine engineers. This paper presents results from a numerical study of clear-water scour depth below a submarine pipeline for a range of the steady flow conditions. The flow field around the pipeline under scour equilibrium condition is numerically simulated by solving the Reynolds-Averaged Navier-Stokes (RANS) equations with the standard k-ε turbulence closure. The flow discharge through the scour hole for various flow conditions is investigated. The results are used to establish the relationship between the flow discharge and the maximum scour depth. Incorporated with the Colebrook-White equation, the bed shear stress is obtained and an iterative method is proposed to predict the scour depth around the submarine pipeline. The calculated scour depths using the present method agree well with the laboratory measurements, with the average absolute relative error being smaller than that using previous methods, indicating that the proposed method can be used to predict the clear-water scour around the submarine pipeline with satisfactory accuracy.National Nature Science Fund of China (Grant No.50879084, 51279189), the Open Fund from the State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University (SKHL1302),China Scholarship Council, Public Projects of Zhejiang Province (2016C33095) and the Natural Science Fund of Zhejiang Province (LQ16E090004)
Radiation Retinopathy: Case report and review
BACKGROUND: Ocular damage from radiation treatment is a well established phenomenon. Many factors are now known to influence the incidence of radiation retinopathy, including total dosage and daily fraction size. Patients who are diabetic, hypertensive or received previous chemotherapy are more susceptible to radiation retinopathy. CASE PRESENTATION: A 55 year old male was referred from the oncology department with epiphora. His medical history included Type 2 Insulin treated Diabetes Mellitus and hypertension. One year prior to presentation he had undergone a total rhinectomy with a 4 week course of post-operative radiotherapy for an aggressive sqaumous cell carcinoma of the nose. On examination the visual acuity was noted to be 6/36 left eye and 6/9 right eye. Posterior segment examination revealed marked retinal ischaemia present in the posterior pole and macular region of both eyes. The appearance was not thought to be typical of diabetic changes, radiation retinopathy being the more likely diagnosis especially in view of his history. Over the next four months the vision in both eyes rapidly deteriorated to 3/60 left eye and 1/60 right eye. Bilateral pan retinal photocoagulation was thought to be appropriate treatment at this point. CONCLUSION: This case highlights the importance for ophthalmologists and oncologists to be aware of the close relationship between diabetes and radiation treatment and the profound rapid impact this combination of factors may have on visual function. Radiation is being used with increasing frequency for ocular and orbital disease, because of this more cases of radiation retinopathy may become prevalent. Factors which may potentiate radiation retinopathy should be well known including, increased radiation dosage, increased fraction size, concomitant systemic vascular disease and use of chemotherapy. Counselling should be offered in all cases at risk of visual loss. As no effective treatment currently exists to restore visual function, monitoring of visual acuity in all cases and early referral to the ophthalmologist as appropriate is warranted
Quantum Computing
Quantum mechanics---the theory describing the fundamental workings of
nature---is famously counterintuitive: it predicts that a particle can be in
two places at the same time, and that two remote particles can be inextricably
and instantaneously linked. These predictions have been the topic of intense
metaphysical debate ever since the theory's inception early last century.
However, supreme predictive power combined with direct experimental observation
of some of these unusual phenomena leave little doubt as to its fundamental
correctness. In fact, without quantum mechanics we could not explain the
workings of a laser, nor indeed how a fridge magnet operates. Over the last
several decades quantum information science has emerged to seek answers to the
question: can we gain some advantage by storing, transmitting and processing
information encoded in systems that exhibit these unique quantum properties?
Today it is understood that the answer is yes. Many research groups around the
world are working towards one of the most ambitious goals humankind has ever
embarked upon: a quantum computer that promises to exponentially improve
computational power for particular tasks. A number of physical systems,
spanning much of modern physics, are being developed for this task---ranging
from single particles of light to superconducting circuits---and it is not yet
clear which, if any, will ultimately prove successful. Here we describe the
latest developments for each of the leading approaches and explain what the
major challenges are for the future.Comment: 26 pages, 7 figures, 291 references. Early draft of Nature 464, 45-53
(4 March 2010). Published version is more up-to-date and has several
corrections, but is half the length with far fewer reference
Radio Emission from Ultra-Cool Dwarfs
The 2001 discovery of radio emission from ultra-cool dwarfs (UCDs), the very
low-mass stars and brown dwarfs with spectral types of ~M7 and later, revealed
that these objects can generate and dissipate powerful magnetic fields. Radio
observations provide unparalleled insight into UCD magnetism: detections extend
to brown dwarfs with temperatures <1000 K, where no other observational probes
are effective. The data reveal that UCDs can generate strong (kG) fields,
sometimes with a stable dipolar structure; that they can produce and retain
nonthermal plasmas with electron acceleration extending to MeV energies; and
that they can drive auroral current systems resulting in significant
atmospheric energy deposition and powerful, coherent radio bursts. Still to be
understood are the underlying dynamo processes, the precise means by which
particles are accelerated around these objects, the observed diversity of
magnetic phenomenologies, and how all of these factors change as the mass of
the central object approaches that of Jupiter. The answers to these questions
are doubly important because UCDs are both potential exoplanet hosts, as in the
TRAPPIST-1 system, and analogues of extrasolar giant planets themselves.Comment: 19 pages; submitted chapter to the Handbook of Exoplanets, eds. Hans
J. Deeg and Juan Antonio Belmonte (Springer-Verlag
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