Measurement of the Positive Muon Anomalous Magnetic Moment to 0.20 ppm

We present a new measurement of the positive muon magnetic anomaly, a_{μ}≡(g_{μ}-2)/2, from the Fermilab Muon g-2 Experiment using data collected in 2019 and 2020. We have analyzed more than 4 times the number of positrons from muon decay than in our previous result from 2018 data. The systematic error is reduced by more than a factor of 2 due to better running conditions, a more stable beam, and improved knowledge of the magnetic field weighted by the muon distribution, ω[over ˜]_{p}^{'}, and of the anomalous precession frequency corrected for beam dynamics effects, ω_{a}. From the ratio ω_{a}/ω[over ˜]_{p}^{'}, together with precisely determined external parameters, we determine a_{μ}=116 592 057(25)×10^{-11} (0.21 ppm). Combining this result with our previous result from the 2018 data, we obtain a_{μ}(FNAL)=116 592 055(24)×10^{-11} (0.20 ppm). The new experimental world average is a_{μ}(exp)=116 592 059(22)×10^{-11} (0.19 ppm), which represents a factor of 2 improvement in precision

Feline low-grade alimentary lymphoma: an emerging entity and a potential animal model for human disease

Background: Low-grade alimentary lymphoma (LGAL) is characterised by the infiltration of neoplastic T-lymphocytes, typically in the small intestine. The incidence of LGAL has increased over the last ten years and it is now the most frequent digestive neoplasia in cats and comprises 60 to 75% of gastrointestinal lymphoma cases. Given that LGAL shares common clinical, paraclinical and ultrasonographic features with inflammatory bowel diseases, establishing a diagnosis is challenging. A review was designed to summarise current knowledge of the pathogenesis, diagnosis, prognosis and treatment of feline LGAL. Electronic searches of PubMed and Science Direct were carried out without date or language restrictions. Results: A total of 176 peer-reviewed documents were identified and most of which were published in the last twenty years. 130 studies were found from the veterinary literature and 46 from the human medicine literature. Heterogeneity of study designs and outcome measures made meta-analysis inappropriate. The pathophysiology of feline LGAL still needs to be elucidated, not least the putative roles of infectious agents, environmental factors as well as genetic events. The most common therapeutic strategy is combination treatment with prednisolone and chlorambucil, and prolonged remission can often be achieved. Developments in immunohistochemical analysis and clonality testing have improved the confidence of clinicians in obtaining a correct diagnosis between LGAL and IBD. The condition shares similarities with some diseases in humans, especially human indolent T-cell lymphoproliferative disorder of the gastrointestinal tract. Conclusions: The pathophysiology of feline LGAL still needs to be elucidated and prospective studies as well as standardisation of therapeutic strategies are needed. A combination of conventional histopathology and immunohistochemistry remains the current gold-standard test, but clinicians should be cautious about reclassifying cats previously diagnosed with IBD to lymphoma on the basis of clonality testing. Importantly, feline LGAL could be considered to be a potential animal model for indolent digestive T-cell lymphoproliferative disorder, a rare condition in human medicine

Surface decontamination treatments for improving the safety of meat and poultry

The microbiological safety of raw beef and poultry products continue to be one of the major concerns of the meat industry. In 2011, an estimated 9.4 million illnesses, 55,961 hospitalizations, and 1,351 deaths were attributed to known foodborne pathogens in the USA including Norovirus caused the most illnesses; nontyphoidal Salmonella spp., norovirus, Campylobacter spp., and Toxoplasma gondii caused the most hospitalizations; and nontyphoidal Salmonella spp., T. gondii, Listeriamonocytogenes, and norovirus caused the most deaths [Scallan et al. (Emerg Infect Dis 17:7–15, 2011)]. Several factors influence the incidence of pathogens in the meat and poultry food supply, some of the more important factors are livestock production practices that may inadvertently foster pathogen contamination; the emergence of “new” and antibiotic-resistant pathogens in the environment; increased manipulation and handling and accelerated processing of carcasses and raw materials; modification of traditional processing practices and greater complexity of manufacturing procedures and equipment; a more complex distribution and food preparation system that increases the risk of foodborne disease; more discriminate and selective pathogen detection methods to improve confirmation and trace-back of contaminated product; and consumer habits that represent inappropriate food handling and preparation practices [Keeton and Eddy (Preharvest and postharvest food safety—contemporary issues and future directions. Blackwell, Ames, 2004)]. The surface decontamination treatments of meat and poultry could improve the safety of these products and help to reduce foodborne illnesses. Details of some surface decontamination treatments of raw meat and poultry are discussed in this review. © 2014, Springer Science+Business Media New York