A formal language towards the unification of model checking and performance evaluation

In computer science, model checking refers to a computation process that, given a formal structure, checks whether the structure satisfies a logic formula which encodes certain properties. If the structure is a discrete state system and the interested properties depend only on which states to be reached, not on the time or probability to reach them, traditional temporal logics such as linear temporal logic (LTL) and computation tree logic (CTL) are powerful mathematical formalisms that can express properties such as \u27\u27no collision shall occur in a traffic light control system\u27\u27, or \u27\u27eventually, a service is completed\u27\u27. To express performance-dependability related properties over discrete state stochastic systems, these logics have evolved into quantitative model checking logics such as probabilistic linear temporal logic (PLTL), probabilistic computation tree logic (PCTL), and computation tree stochastic logic (CSL), etc., and can express properties such as ``with probability at least 0.98, the system will not reach a deadlock state before time 100\u27\u27. While these logics and their model checking algorithms are powerful, they are inadequate in expressing complex performance measures, either because they are limited to producing only true/false responses (although in practice, a real valued response can sometimes be obtained for the outer-most path quantifier), or the computational complexity is too expensive to be practical. To address these limitations, for this PhD work, we propose a novel mechanism with the following research aims: 1) Define general specification formalisms to express performance queries in real values while retaining the ability to express temporal properties. 2) Develop efficient mathematical algorithms for the proposed formalisms. 3)Implement the approach in tools and experiment on large-scaled Markov models for the analysis of example queries

An Empirical Study on Personal Health Records System based on Individual and Environmental Features

To promote the adoption of PHR system, understanding the factors that affect patients’ adoption of PHR system is of necessity. Based on previous research, this paper tries to develop a model to explore those elements that influence the behavior intentions of patients from the perspective of consumers. It is assumed that individual features and environmental features affect individuals’ attitudes to PHR. Data from 265 participants’ response to questionnaire was collected. The SPSS and partial least squares (PLS) technique was adopted to examine the casual relationships this paper hypothesized. The results show that affordability and coercive pressure have the significant effect on individuals’ attitude towards PHR. Therefore, suggestion regarding what developers, institutions and government should do to improve the adoption rate of PHR was raised

Towards the representation of design patterns as design components

Design patterns encapsulate accumulated software design knowledge and implementation experience. While they exist, in general, as informal guidelines that describe reusable design solutions to recurring problems in software development, they are not available as code abstractions and thus not ready to be incorporated into a concrete system implementation. In order to propagate the design patterns\u27 reusability from design phase to implementation phase, this work presents an approach that differentiates between code-reusable and non-code-reusable design patterns. Using this classification, we develop a method that allows for representing code-reusable design patterns as reusable design components. These design components, when applied to application-specific design participants via well-defined protocols and/or interfaces, output concrete pattern-specific code ready to be incorporated into concrete system implementations. Through experimentation on GoF\u27s design pattern catalog, we have identified 12 design patterns that can be classified as code-reusable and promoted them to reusable design components. These design components, although implemented in Java, exhibit very similar properties as shown in Hannemann and Kiczales\u27 AspectJ implementation of design patterns in terms of reusability and pluggability

Students’ Ability Evaluation Structure Model of Local Finance and Economic Universities

The students’ ability evaluation of local finance and economic universities is conducive to the cultivation of talents, and to promote local economic development. In order to objectively evaluate the students’ ability of local finance and economic universities, this paper divides the ability of college students into three dimensions, including basic quality and ability, professional competence, the ability of innovation and practice. This paper builds the students’ ability evaluation indicator system of local finance and economic universities, and designs evaluation indicator system scale tables. Collecting data from high school students, teachers and the employers through paper questionnaires and web-based survey, this paper uses principal component analysis to extract ability factors, and establishes the students’ ability evaluation structure model of local finance and economic universities. This study provides a theoretical reference for the objective evaluation of students’ ability and training students’ ability purposefully

WebGIS-based Natural Disaster Information System of China

We have constructed China natural disaster information system utilizing open source WebGIS framework. Through comparisons and researches on different WebGIS system structures, implementation patterns, spatial database management patterns and several popular software, open source WebGIS platform MapServer, PostgreSQL+PostGIS (spatial database and spatial data engine), client-side browser framework openLayer were used. This system have basic function of web information publishing, spatial data storage and management, and it collects natural disaster information that have been publishing on the internet through grabing internet information, and based on the analysis to the text information, different kinds of natural disaster information databases were constructed. Additionally, locations of the disaster occurred were combined to provide map services, and the system is able to meet multi-user access issues, and have functions of thematic mapping, query and statistics, charting and output, et.al

Characterization of Laser-Resistant Port Wine Stain Blood Vessels Using In Vivo Reflectance Confocal Microscopy.

Background and objectivesPort wine stain (PWS) is a congenital vascular malformation of the human skin. Laser is the treatment of choice for PWS. Laser-resistant PWS is one crucial factor accounting for inadequate treatment outcome, which needs to be fully characterized. This study aims to quantitatively characterize the morphology of laser-resistant PWS blood vessels in the upper papillary dermis using in vivo reflectance confocal microscopy (RCM).Study design/materials and methodsA total of 42 PWS subjects receiving laser treatment from August 2016 through July 2018 were enrolled into this study. Thirty-three subjects had facial PWS; nine had extremity PWS. All subject's PWS received multiplex 585/1,064 nm laser treatment. RCM images were taken before and after treatment. The density, diameter, blood flow, and depth of PWS blood vessels were analyzed.ResultsWe found 44.4% PWS on the extremities (four out of nine subjects) were laser-resistant, which was significantly higher (P < 0.001) when compared with those PWS on the face (15.2%, 5 out of 33 subjects). The laser-resistant facial PWS blood vessels had significantly higher blood flow (1.35 ± 0.26 U vs. 0.89 ± 0.22 U, P < 0.001), larger blood vessel diameters (109.60 ± 18.24 µm vs. 84.36 ± 24.04 µm, P = 0.033) and were located deeper in the skin (106.01 ± 13.87 µm vs. 87.82 ± 12.57 µm, P < 0.001) in the skin when compared with laser-responsive PWS on the face. The average PWS blood vessel density (17.01 ± 4.63/mm2 vs. 16.61 ± 4.44/mm2 , P = 0.857) was not correlated to the laser resistance.ConclusionsLaser-resistant PWS blood vessels had significantly higher blood flow, larger diameters, and were located deeper in the skin. RCM can be a valuable tool for a prognostic evaluation on laser-resistant lesions before treatment, thereby providing guidance for tailored laser treatment protocols, which may improve the therapeutic outcome. The limitations for this study include relative small sample size and acquisitions of different blood vessels before and after 2 months of treatment. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc

GeoDjango-Framwork-based Population and Social Economic Information System For China

We have constructed China population and social economic information system based on open source geographic Web framework GeoDjango. By comparing different WebGIS system structures, implementation patterns, spatial database management patterns and mainstream popular open source APIs, open source WebGIS framework GeoDjango, MVT pattern, Python and MySQL database, client-side browser framework openLayer were implemented. The database system utilized a Top-Down design method — DATAID-D to establish distributed database, and construct a uniform encoding standard, through normalized processes of the statistic yearbook, we constructed population and social economic database. This system has basic functions of web information publishing, spatial data storage, distributed management and spatial query. Additionally, the system is able to meet multi-user access issues, and have functions of population and economy data visualization, thematic mapping, query and statistics, charting and output, et.al

1, 25-Dihydroxyvitamin D3 suppresses cell cycle progression and thus growth of prostate cancer cells by inducing expression of limb bud and heart development (LBH)

Purpose: To investigate the function of limb bud and heart development (LBH) in 1α, 25-dihydroxyvitamin D3 (1,25D)-mediated inhibitory effect on proliferation of prostate cancer cells.Methods: The inhibitory effect of 1,25D on growth and cell cycle progression of lymph node carcinoma of the prostate (LNCaP) cells was determined using cell counting kit-8 (CCK-8) assay, 5-ethynyl-2'-deoxyuridine (EdU) assay and flow cytometry, while the expression levels of LBH in response to treatment with 1,25D were determined by quantitative reverse-transcription PCR (qRT-PCR) and western blottingting. The expression levels of LBH in cells were down/up regulated by transfection with siRNA or overexpression plasmids, and then cell growth and cell cycles were measured using the CCK-8 assay, EdU assay, and flow cytometry. Finally, the growth inhibitory effect of 1,25D on LBH knockdown cells were determined using CCK-8 and EdU assays.Results: Treatment with 1,25D arrested LNCaP cells in G0/G1 phase of cell cycle, suppressed the growth of the cells and induced the expression of LBH. Overexpression/knockdown of LBH in LNCaP cells suppressed/promoted cell growth and accumulated/decreased cells in the G0/G1 phase. Moreover, knockdown of LBH reversed the inhibitory effect of 1,25D on cell proliferation of LNCaP cells.Conclusion: Inhibitory effect of 1,25D on cell cycle progression and cell proliferation might be via LBH.Keywords: Cell proliferation, Limb bud and heart development, Prostate cancer, 1α, 25-Dihydroxyvitamin D