9 research outputs found
The effect of ultrasound irradiation on the physicochemical properties and α-glucosidase inhibitory effect of blackberry fruit polysaccharide
Effect of virgin olive oil and thyme phenolic compounds on blood lipid profile: implications of human gut microbiota.
PURPOSE: To investigate the effect of virgin olive oil phenolic compounds (PC) alone or in combination with thyme PC on blood lipid profile from hypercholesterolemic humans, and whether the changes generated are related with changes in gut microbiota populations and activities. METHODS: A randomized, controlled, double-blind, crossover human trial (n = 12) was carried out. Participants ingested 25 mL/day for 3 weeks, preceded by 2-week washout periods, three raw virgin olive oils differing in the concentration and origin of PC: (1) a virgin olive oil (OO) naturally containing 80 mg PC/kg, (VOO), (2) a PC-enriched virgin olive oil containing 500 mg PC/kg, from OO (FVOO), and (3) a PC-enriched virgin olive oil containing a mixture of 500 mg PC/kg from OO and thyme, 1:1 (FVOOT). Blood lipid values and faecal quantitative changes in microbial populations, short chain fatty acids, cholesterol microbial metabolites, bile acids, and phenolic metabolites were analysed. RESULTS: FVOOT decreased seric ox-LDL concentrations compared with pre-FVOOT, and increased numbers of bifidobacteria and the levels of the phenolic metabolite protocatechuic acid compared to VOO (P < 0.05). FVOO did not lead to changes in blood lipid profile nor quantitative changes in the microbial populations analysed, but increased the coprostanone compared to FVOOT (P < 0.05), and the levels of the faecal hydroxytyrosol and dihydroxyphenylacetic acids, compared with pre-intervention values and to VOO, respectively (P < 0.05). CONCLUSION: The ingestion of a PC-enriched virgin olive oil, containing a mixture of olive oil and thyme PC for 3 weeks, decreases blood ox-LDL in hypercholesterolemic humans. This cardio-protective effect could be mediated by the increases in populations of bifidobacteria together with increases in PC microbial metabolites with antioxidant activities.This work was supported by Instituto de Salud Carlos III FEDER (RD12-0042, CB06/03/0028, CD10/00224, CP06/00100, CB06/02/0029, CA11/00215), Ministry of Economy and Competitiveness (AGL2012-40144-C03-01, AGL2012-40144-C03-02, AGL2012-40144-C03-03, FPI:BES- 2010-040766), Agency for Management of University and Research Grants (2009 SGR 1195, 2014 SGR 240). We thank M Angels Calvo for the growth of pure cultures, MalĂ©n Massot for helping us in the elaboration of the FISH-FC protocol, Ăscar Fornas and Cristina Llop for their technical assistance and Borges Mediterranean
Group.http://dx.doi.org/10.1007/s00394-015-1063-
Evolution of cranberry juice compounds during in vitro digestion and identification of the organic acid responsible for the disruption of in vitro intestinal cell barrier integrity
Stability of total phenolic concentration and antioxidant capacity of extracts from pomegranate co-products subjected to in vitro digestion
Effects of simulated digestion on the phenolic composition and antioxidant activity of different cultivars of lychee pericarp
Antioxidants in Diets and Food
none3noNowadays, the society looks with increasing interest in the diet, which is no
longer simply a means by which to take the necessary nutrients but has become a
means by which it is possible to preserve the health state. German philosopher
Ludwig Feuerbach once said: âWe are what we eat.â This statement is even truer
today because of the hectic life, people often tend to eat frugal, fast, and often
very fat and unhealthy meals. Today, there is a very high attention both from the
social point of view and by the scientific community to the so-called functional
foods. These foods, which contain several bioactive compounds, exert innumerable
biological properties and therefore can help to preserve the health state. In
addition, the use of nutraceuticals has taken the upper hand, unfortunately, often
also to the detriment of functional foods, which unlike the former still remain
foods and, as such, with a certainly better efficacy-safety profile. The term
nutraceutical, indeed, does not refer to a food but rather to a formulation
containing one or more compounds isolated from plant extracts or one or more
titrated plant extracts. Moreover, some formulations (capsules, tablets, powders,
etc.) are rarely studied before being commercialized, and their effectiveness
remains rather doubtful in light of a very lax regulation in many countries
worldwide.mixedAntonella Smeriglio, Laura Cornara, Domenico TrombettaSmeriglio, Antonella; Cornara, Laura; Trombetta, Domenic