Spatial variation of heart failure and air pollution in Warwickshire, UK : an investigation of small scale variation at the ward-level

Objectives To map using geospatial modelling techniques the morbidity and mortality caused by heart failure within Warwickshire to characterise and quantify any influence of air pollution on these risks. Design Cross-sectional. Setting Warwickshire, UK. Participants Data from all of the 105 current Warwickshire County wards were collected on hospital admissions and deaths due to heart failure. Results In multivariate analyses, the presence of higher mono-nitrogen oxide (NOx) in a ward (3.35:1.89, 4.99), benzene (Ben) (31.9:8.36, 55.85) and index of multiple deprivation (IMD; 0.02: 0.01, 0.03), were consistently associated with a higher risk of heart failure morbidity. Particulate matter (Pm; −12.93: −20.41, −6.54) was negatively associated with the risk of heart failure morbidity. No association was found between sulfur dioxide (SO2) and heart failure morbidity. The risk of heart failure mortality was higher in wards with a higher NOx (4.30: 1.68, 7.37) and wards with more inhabitants 50+ years old (1.60: 0.47, 2.92). Pm was negatively associated (−14.69: −23.46, −6.50) with heart failure mortality. SO2, Ben and IMD scores were not associated with heart failure mortality. There was a prominent variation in heart failure morbidity and mortality risk across wards, the highest risk being in the regions around Nuneaton and Bedworth. Conclusions This study showed distinct spatial patterns in heart failure morbidity and mortality, suggesting the potential role of environmental factors beyond individual-level risk factors. Air pollution levels should therefore be taken into account when considering the wider determinants of public health and the impact that changes in air pollution might have on the health of a population

Large anomalous Hall effect in ferromagnetic insulator-topological insulator heterostructures

We demonstrate the van der Waals epitaxy of the topological insulator compound Bi2Te3 on the ferromagnetic insulator Cr2Ge2Te6. The layers are oriented with (001) of Bi2Te3 parallel to (001) of Cr2Ge2Te6 and (110) of Bi2Te3 parallel to (100) of Cr2Ge2Te6. Cross-sectional transmission electron microscopy indicates the formation of a sharp interface. At low temperatures, bilayers consisting of Bi2Te3 on Cr2Ge2Te6 exhibit a large anomalous Hall effect (AHE). Tilted field studies of the AHE indicate that the easy axis lies along the c-axis of the heterostructure, consistent with magnetization measurements in bulk Cr2Ge2Te6. The 61 K Curie temperature of Cr2Ge2Te6 and the use of near-stoichiometric materials may lead to the development of spintronic devices based on the AHE.Comment: Related papers at http://pettagroup.princeton.ed

Microstructural Pattern Formation during Far-from-Equilibrium Alloy Solidification

We introduce a new phase-field formulation of rapid alloy solidification that quantitatively incorporates non-equilibrium effects at the solid-liquid interface over a very wide range of interface velocities. Simulations identify a new dynamical instability of dendrite tip growth driven by solute trapping at velocities approaching the absolute stability limit. They also reproduce the formation of the widely observed banded microstructures, revealing how this instability triggers transitions between dendritic and microsegregation-free solidification. Predicted band spacings agree quantitatively with observations in rapidly solidified Al-Cu thin films

Design of temperature insurance index and risk zonation for single-season rice in response to high-temperature and low-temperature damage: a case study of Jiangsu Province, China.

Disaster insurance is an important tool for achieving sustainable development in modern agriculture. However, in China, the design of such insurance indexes is far from sufficient. In this paper, the single-season rice in Jiangsu Province of China is taken as an example to design the high-temperature damage index in summer and the low-temperature damage index in autumn to constructtheformulacalculatingtheweatheroutputandsingle-seasonriceyieldreduction. Thedaily highest, lowest and average temperatures between 1999 and 2015 are selected as main variables for the temperature disaster index to quantitatively analyze the relationship between the temperature indexandtheyieldreductionrateofthesingle-seasonrice. Thetemperaturedisasterindexcanbeput into the relevant model to obtain the yield reduction rate of the year and determine whether to pay the indemnity. Then, the burn analysis is used to determine the insurance premium rate for all cities in Jiangsu Province under four-level deductibles, and the insurance premium rate can be used for the risk division of the Province. The research provides some insights for the design of agricultural weather insurance products, and the empirical results provide a reference for the design of similar single-season rice temperature index insurance products

Surface-Bound Cucurbit[8]uril Catenanes on Magnetic Nanoparticles Exhibiting Molecular Recognition.

We demonstrate the preparation of surface-bound cucurbit[8]uril (CB[8]) catenanes on silica nanoparticles (NPs), where CB[8] was employed as a tethered supramolecular "handcuff" to selectively capture target guest molecules. In this catenane, CB[8] was threaded onto a methyl viologen (MV(2+) ) axle and immobilized onto silica NPs. The formation of CB[8] catenanes on NPs were confirmed by UV/Vis titration experiments and lithographic characterization, demonstrating a high density of CB[8] on the silica NPs surface, 0.56 nm(-2) . This CB[8] catenane system exhibits specific molecular recognition towards certain aromatic molecules such as perylene bis(diimide), naphthol and aromatic amino acids, and thus it can act as a nanoscale molecular receptor for target guests. Furthermore, we also demonstrate its use as an efficient and recyclable nano-platform for peptide separation. By embedding magnetic NPs inside silica NPs, separation could be achieved by simply applying an external magnetic field. Moreover, the peptides captured by the catenanes could be released by reversible single-electron reduction of MV(2+) . The entire process demonstrated high recoverability.X. Ren thanks the CSC Cambridge Scholarship for financial support and Dr. Ziyi Yu for template preparation. Y. Wu is financially supported by the EP/L504920/1, J. Liu by the Marie Curie FP7 SASSYPOL ITN (607602) programme, and G. Wu by the Leverhulme Trust.This is the author accepted manuscript. The final version is available from Wiley at http://dx.doi.org/10.1002/asia.201600875

New Environmental-Thermal Barrier Coatings for Ultrahigh Temperature Alloys

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Fracture of a Polyethylene Tibial Post in a Scorpio Posterior-Stabilized Knee Prosthesis

We report the case of a polyethylene tibial post fracture in a 72-year-old woman 14 months after a Scorpio posterior-stabilized (PS) total knee arthroplasty. The polyethylene wear was found around the fracture site of the post, especially over the anterior aspect of the post base. The failure mechanism of the post fracture in the present case was anterior impingement with excessive wear over the base of the anterior aspect of the tibial post, which became a stress-riser of post and cam articulation. This is the first report of a polyethylene tibial post fracture of a Scorpio PS prosthesis

Chandra and XMM-Newton observations of the merging cluster of galaxies PLCK G036.7+14.9

We present Chandra and XMM-Newton observations of PLCK G036.7+14.9 from the Chandra-Planck Legacy Program. The high resolution X-ray observations reveal two close subclusters, G036N and G036S, which were not resolved by previous ROSAT, optical, or recent Planck observations. We perform detailed imaging and spectral analyses and use a simplified model to study the kinematics of this system. The basic picture is that PLCK G036.7+14.9 is undergoing a major merger (mass ratio close to unity) between the two massive subclusters, with the merger largely along the line-of-sight and probably at an early stage. G036N hosts a small, moderate cool-core, while G036S has at most a very weak cool-core in the central 40 kpc region. The difference in core cooling times is unlikely to be caused by the ongoing merger disrupting a pre-existing cool-core in G036S. G036N also hosts an unresolved radio source in the center, which may be heating the gas if the radio source is extended. The Planck derived mass is higher than the X-ray measured mass of either subcluster, but is lower than the X-ray measured mass of the whole cluster, due to the fact that Planck does not resolve PLCK G036.7+14.9 into subclusters and interprets it as a single cluster. This mass discrepancy could induce significant bias to the mass function if such previously unresolved systems are common in the Planck cluster sample. High resolution X-ray observations are necessary to identify the fraction of such systems and correct such a bias for the purpose of precision cosmological studies.Comment: 23 pages, 8 figures (low resolution) with additional 12 figures in the Appendix, accepted for publication in Ap

Strong semismoothness of eigenvalues of symmetric matrices and its application to inverse eigenvalue problems

10.1137/S0036142901393814SIAM Journal on Numerical Analysis4062352-2367SJNA