624 research outputs found
Phase-slip induced dissipation in an atomic Bose-Hubbard system
Phase slips play a primary role in dissipation across a wide spectrum of
bosonic systems, from determining the critical velocity of superfluid helium to
generating resistance in thin superconducting wires. This subject has also
inspired much technological interest, largely motivated by applications
involving nanoscale superconducting circuit elements, e.g., standards based on
quantum phase-slip junctions. While phase slips caused by thermal fluctuations
at high temperatures are well understood, controversy remains over the role of
phase slips in small-scale superconductors. In solids, problems such as
uncontrolled noise sources and disorder complicate the study and application of
phase slips. Here we show that phase slips can lead to dissipation for a clean
and well-characterized Bose-Hubbard (BH) system by experimentally studying
transport using ultra-cold atoms trapped in an optical lattice. In contrast to
previous work, we explore a low velocity regime described by the 3D BH model
which is not affected by instabilities, and we measure the effect of
temperature on the dissipation strength. We show that the damping rate of
atomic motion-the analogue of electrical resistance in a solid-in the confining
parabolic potential fits well to a model that includes finite damping at zero
temperature. The low-temperature behaviour is consistent with the theory of
quantum tunnelling of phase slips, while at higher temperatures a cross-over
consistent with the transition to thermal activation of phase slips is evident.
Motion-induced features reminiscent of vortices and vortex rings associated
with phase slips are also observed in time-of-flight imaging.Comment: published in Nature 453, 76 (2008
Evolution of cooperation driven by zealots
Recent experimental results with humans involved in social dilemma games
suggest that cooperation may be a contagious phenomenon and that the selection
pressure operating on evolutionary dynamics (i.e., mimicry) is relatively weak.
I propose an evolutionary dynamics model that links these experimental findings
and evolution of cooperation. By assuming a small fraction of (imperfect)
zealous cooperators, I show that a large fraction of cooperation emerges in
evolutionary dynamics of social dilemma games. Even if defection is more
lucrative than cooperation for most individuals, they often mimic cooperation
of fellows unless the selection pressure is very strong. Then, zealous
cooperators can transform the population to be even fully cooperative under
standard evolutionary dynamics.Comment: 5 figure
NLO QCD corrections to off-shell top-antitop production with leptonic decays at hadron colliders
We present details of a calculation of the cross section for hadronic
top-antitop production in next-to-leading order (NLO) QCD, including the decays
of the top and antitop into bottom quarks and leptons. This calculation is
based on matrix elements for \nu e e+ \mu- \bar{\nu}_{\mu}b\bar{b} production
and includes all non-resonant diagrams, interferences, and off-shell effects of
the top quarks. Such contributions are formally suppressed by the top-quark
width and turn out to be small in the inclusive cross section. However, they
can be strongly enhanced in exclusive observables that play an important role
in Higgs and new-physics searches. Also non-resonant and off-shell effects due
to the finite W-boson width are investigated in detail, but their impact is
much smaller than naively expected. We also introduce a matching approach to
improve NLO calculations involving intermediate unstable particles. Using a
fixed QCD scale leads to perturbative instabilities in the high-energy tails of
distributions, but an appropriate dynamical scale stabilises NLO predictions.
Numerical results for the total cross section, several distributions, and
asymmetries are presented for Tevatron and the LHC at 7 TeV, 8 TeV, and 14 TeV.Comment: 61 pp. Matches version published in JHEP; one more reference adde
Glucocorticoid sensitivity in Behcet's disease
WOS: 000209773300007PubMed ID: 23781311Objective: Glucocorticoid (GC) sensitivity is highly variable among individuals and has been associated with susceptibility to develop (auto-) inflammatory disorders. The purpose of the study was to assess GC sensitivity in Behcet's disease (BD) by studying the distribution of four GC receptor (GR) gene polymorphisms and by measuring in vitro cellular GC sensitivity. Methods: Healthy controls and patients with BD in three independent cohorts were genotyped for four functional GR gene polymorphisms. To gain insight into functional differences in in vitro GC sensitivity, 19 patients with BD were studied using two bioassays and a whole-cell dexamethasone-binding assay. Finally, mRNA expression levels of GR splice variants (GR-alpha and GR-beta) were measured. Results: Healthy controls and BD patients in the three separate cohorts had similar distributions of the four GR polymorphisms. The Bcll and 9 beta minor alleles frequency differed significantly between Caucasians and Mideast and Turkish individuals. At the functional level, a decreased in vitro cellular GC sensitivity was observed. GR number in peripheral blood mononuclear cells was higher in BD compared with controls. The ratio of GR-alpha/GR-beta mRNA expression levels was significantly lower in BD. Conclusions: Polymorphisms in the GR gene are not associated with susceptibility to BD. However, in vitro cellular GC sensitivity is decreased in BD, possibly mediated by a relative higher expression of the dominant negative GR-b splice variant. This decreased in vitro GC sensitivity might play an as yet unidentified role in the pathophysiology of BD.The Dutch Arthritis AssociationThis work was supported by a grant from The Dutch Arthritis Association
Photon Radiation with MadDipole
We present the automation of a subtraction method for photon radiation using
the dipole formalism within the MadGraph framework. The subtraction terms are
implemented both in dimensional regularization and mass regularization for
massless and massive cases and non-collinear-safe observables are accounted
for.Comment: 23 pages, 2 figures, minor additions, references added, version
published in JHE
Analogue peptides for the immunotherapy of human acute myeloid leukemia
Accepted manuscript. The final publication is available at: http://link.springer.com/article/10.1007%2Fs00262-015-1762-9The use of peptide vaccines, enhanced by adjuvants, has shown some efficacy in clinical trials. However, responses are often short-lived and rarely induce notable memory responses. The reason is that self-antigens have already been presented to the immune system as the tumor develops, leading to tolerance or some degree of host tumor cell destruction. To try to break tolerance against self-antigens, one of the methods employed has been to modify peptides at the anchor residues to enhance their ability to bind major histocompatibility complex molecules, extending their exposure to the T-cell receptor. These modified or analogue peptides have been investigated as stimulators of the immune system in patients with different cancers with variable but sometimes notable success. In this review we describe the background and recent developments in the use of analogue peptides for the immunotherapy of acute myeloid leukemia describing knowledge useful for the application of analogue peptide treatments for other malignancies
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Community projects: an experimental analysis of a fair implementation process
We define and experimentally test a public provision mechanism that meets three basic ethical requirements and allows community members to influence, via monetary bids, which of several projects is implemented. For each project, participants are assigned personal values, which can be positive or negative. We provide either public or private information about personal values. This produces two distinct public provision games, which are experimentally implemented and analyzed for various projects. In spite of the complex experimental task, participants do not rely on bidding their own personal values as an obvious simple heuristic whose general acceptance would result in fair and efficient outcomes. Rather, they rely on strategic underbidding. Although underbidding is affected by projects’ characteristics, the provision mechanism mostly leads to the implementation of the most efficient project
Flavour-coherent propagators and Feynman rules: Covariant cQPA formulation
We present a simplified and generalized derivation of the flavour-coherent
propagators and Feynman rules for the fermionic kinetic theory based on
coherent quasiparticle approximation (cQPA). The new formulation immediately
reveals the composite nature of the cQPA Wightman function as a product of two
spectral functions and an effective two-point interaction vertex, which
contains all quantum statistical and coherence information. We extend our
previous work to the case of nonzero dispersive self-energy, which leads to a
broader range of applications. By this scheme, we derive flavoured kinetic
equations for local 2-point functions , which are
reminiscent of the equations of motion for the density matrix. We emphasize
that in our approach all the interaction terms are derived from first
principles of nonequilibrium quantum field theory.Comment: 20 pages, 3 figures. Minor modifications, version published in JHE
Recrudescence of massive fermion production by oscillons
We bring together the physics of preheating, following a period of inflation, and the dynamics of non-topological solitons, namely oscillons. We show that the oscillating condensate that makes up an oscillon can be an efficient engine for producing heavy fermions, just as a homogeneous condensate is known for doing the same. This then allows heavy fermions to be produced when the energy scale of the Universe has dropped below the scale naturally associated to the fermions
Bioavailability of Iron, Zinc, Phytate and Phytase Activity during Soaking and Germination of White Sorghum Varieties
The changes in phytate, phytase activity and in vitro bioavailability of iron and zinc during soaking and germination of three white sorghum varieties (Sorghum bicolor L. Moench), named Dorado, Shandweel-6, and Giza-15 were investigated. Sorghum varieties were soaked for 20 h and germinated for 72 h after soaking for 20 h to reduce phytate content and increase iron and zinc in vitro bioavailability. The results revealed that iron and zinc content was significantly reduced from 28.16 to 32.16% and 13.78 to 26.69% for soaking treatment and 38.43 to 39.18% and 21.80 to 31.27% for germination treatments, respectively. Phytate content was significantly reduced from 23.59 to 32.40% for soaking treatment and 24.92 to 35.27% for germination treatments, respectively. Phytase enzymes will be activated during drying in equal form in all varieties. The results proved that the main distinct point is the change of phytase activity as well as specific activity during different treatment which showed no significant differences between the varieties used. The in vitro bioavailability of iron and zinc were significantly improved as a result of soaking and germination treatments
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