433 research outputs found
Chiral Behaviour of the Rho Meson in Lattice QCD
In order to guide the extrapolation of the mass of the rho meson calculated
in lattice QCD with dynamical fermions, we study the contributions to its
self-energy which vary most rapidly as the quark mass approaches zero; from the
processes and . It turns out that in
analysing the most recent data from CP-PACS it is crucial to estimate the
self-energy from using the same grid of discrete momenta as
included implicitly in the lattice simulation. The correction associated with
the continuum, infinite volume limit can then be found by calculating the
corresponding integrals exactly. Our error analysis suggests that a factor of
10 improvement in statistics at the lowest quark mass for which data currently
exists would allow one to determine the physical rho mass to within 5%.
Finally, our analysis throws new light on a long-standing problem with the
J-parameter.Comment: 13 pages, 7 figures. Full analytic forms of the self-energies are
included and a correction in the omega-pi self-energ
Applying phylogenomics to understand the emergence of Shiga Toxin producing Escherichia coli O157:H7 strains causing severe human disease in the United Kingdom
Shiga Toxin producing Escherichia coli (STEC) O157:H7 is a recently emerged zoonotic pathogen with considerable morbidity. Since the serotype emerged in the 1980s, research has focussed on unravelling the evolutionary events from the E. coli O55:H7 ancestor to the contemporaneous globally dispersed strains. In this study the genomes of over 1000 isolates from human clinical cases and cattle, spanning the history of STEC O157:H7 in the United Kingdom were sequenced. Phylogenetic analysis reveals the ancestry, key acquisition events and global context of the strains. Dated phylogenies estimate the time to the most recent common ancestor of the current circulating global clone to 175 years ago, followed by rapid diversification. We show the acquisition of specific virulence determinates occurred relatively recently and coincides with its recent detection in the human population. Using clinical outcome data from 493 cases of STEC O157:H7 we assess the relative risk of severe disease including HUS from each of the defined clades in the population and show the dramatic effect Shiga toxin complement has on virulence. We describe two strain replacement events that have occurred in the cattle population in the UK over the last 30 years; one resulting in a highly virulent strain that has accounted for the majority of clinical cases in the UK over the last decade. This work highlights the need to understand the selection pressures maintaining Shiga-toxin encoding bacteriophages in the ruminant reservoir and the study affirms the requirement for close surveillance of this pathogen in both ruminant and human populations
Baryon Charge Radii and Quadrupole Moments in the 1/N_c Expansion: The 3-Flavor Case
We develop a straightforward method to compute charge radii and quadrupole
moments for baryons both with and without strangeness, when the number of QCD
color charges is N_c. The minimal assumption of the single-photon exchange
ansatz implies that only two operators are required to describe these baryon
observables. Our results are presented so that SU(3) flavor and isospin
symmetry breaking can be introduced according to any desired specification,
although we also present results obtained from two patterns suggested by the
quark model with gluon exchange interactions. The method also permits to
extract a number of model-independent relations; a sample is r^2_Lambda / r_n^2
= 3/(N_c+3), independent of SU(3) symmetry breaking.Comment: 30 pages, no figures, REVTeX
Extragenic suppressor mutations in ΔripA disrupt stability and function of LpxA
Background: Francisella tularensis is a Gram-negative bacterium that infects hundreds of species including humans, and has evolved to grow efficiently within a plethora of cell types. RipA is a conserved membrane protein of F. tularensis, which is required for growth inside host cells. As a means to determine RipA function we isolated and mapped independent extragenic suppressor mutants in ΔripA that restored growth in host cells. Each suppressor mutation mapped to one of two essential genes, lpxA or glmU, which are involved in lipid A synthesis. We repaired the suppressor mutation in lpxA (S102, LpxA T36N) and the mutation in glmU (S103, GlmU E57D), and demonstrated that each mutation was responsible for the suppressor phenotype in their respective strains. We hypothesize that the mutation in S102 altered the stability of LpxA, which can provide a clue to RipA function. LpxA is an UDP-N-acetylglucosamine acyltransferase that catalyzes the transfer of an acyl chain from acyl carrier protein (ACP) to UDP-N-acetylglucosamine (UDP-GlcNAc) to begin lipid A synthesis. Results: LpxA was more abundant in the presence of RipA. Induced expression of lpxA in the ΔripA strain stopped bacterial division. The LpxA T36N S102 protein was less stable and therefore less abundant than wild type LpxA protein. Conclusion: These data suggest RipA functions to modulate lipid A synthesis in F. tularensis as a way to adapt to the host cell environment by interacting with LpxA
Chiral extrapolation of lattice data for the hyperfine splittings of heavy mesons
Hyperfine splittings between the heavy vector (D*, B*) and pseudoscalar (D,
B) mesons have been calculated numerically in lattice QCD, where the pion mass
(which is related to the light quark mass) is much larger than its physical
value. Naive linear chiral extrapolations of the lattice data to the physical
mass of the pion lead to hyperfine splittings which are smaller than
experimental data. In order to extrapolate these lattice data to the physical
mass of the pion more reasonably, we apply the effective chiral perturbation
theory for heavy mesons, which is invariant under chiral symmetry when the
light quark masses go to zero and heavy quark symmetry when the heavy quark
masses go to infinity. This leads to a phenomenological functional form with
three parameters to extrapolate the lattice data. It is found that the
extrapolated hyperfine splittings are even smaller than those obtained using
linear extrapolation. We conclude that the source of the discrepancy between
lattice data for hyperfine splittings and experiment must lie in non-chiral
physics.Comment: 27 pages, 6 figure
On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination
Antibiotics are commonly used as the first line of defense in the treatment of infectious diseases. However, the rise of antimicrobial resistance (AMR) is rendering many antibiotics less effective. Consequently, effective non-antibiotic antimicrobial strategies are urgently needed to combat AMR. This paper presents a strategy utilizing cold plasma for the "on-demand"activation of acetyl donor molecules. The process generates an aqueous-based antimicrobial formulation comprising a rich mixture of highly oxidizing molecules: peracetic acid, hydrogen peroxide, and other reactive oxygen and nitrogen species. The synergistic potent oxidative action between these molecules is shown to be highly effective at eradicating common wound pathogenic bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) and at inactivating a virus (SARS-CoV-2)
The semileptonic decays of the B_c meson
We study the semileptonic transitions B_c to \eta_c, J/\psi, D, D^*, B, B^*,
B_s, B_s^* in the framework of a relativistic constituent quark model. We use
experimental data on leptonic J/\psi decay, lattice and QCD sum rule results on
leptonic B_c decay, and on radiative \eta_c transitions to adjust the quark
model parameters. We compute all form factors of the above semileptonic
B_c-transitions and give predictions for various semileptonic B_c decay modes
including their \tau-modes when they are kinematically accessible. The
implications of heavy quark symmetry for the semileptonic decays are discussed
and are shown to be manifest in our explicit relativistic quark model
calculation. A comparison of our results with the results of other calculations
is performed.Comment: 31 pages Latex (uses epsf, revtex). Section II expanded, typos
corrected. This version will appear in Phys. Rev.
Extragalactic neutrino background from very young pulsars surrounded by supernova envelopes
We estimate the extragalactic muon neutrino background which is produced by
hadrons injected by very young pulsars at an early phase after supernova
explosion. It is assumed that hadrons are accelerated in the pulsar wind zone
which is filled with thermal photons captured below the expanding supernova
envelope. In collisions with those thermal photons hadrons produce pions which
decay into muon neutrinos. At a later time, muon neutrinos are also produced by
the hadrons in collisions with matter of the expanding envelope. We show that
extragalactic neutrino background predicted by such a model should be
detectable by the planned 1 km neutrino detector if a significant part of
pulsars is born with periods shorter than ms. Since such population
of pulsars is postulated by the recent models of production of extremely high
energy cosmic rays, detection of neutrinos with predicted fluxes can be used as
their observational test.Comment: 4 pages, 2 figures, A&A style, accepted to A&A Let
Quark contributions to baryon magnetic moments in full, quenched, and partially quenched QCD
The chiral nonanalytic behavior of quark-flavor contributions to the magnetic moments of octet baryons is determined in full, quenched and partially quenched QCD, using an intuitive and efficient diagrammatic formulation of quenched and partially quenched chiral perturbation theory. The technique provides a separation of quark-sector magnetic-moment contributions into direct sea-quark loop, valence-quark, indirect sea-quark loop and quenched valence contributions, the latter being the conventional view of the quenched approximation. Both meson and baryon mass violations of SU(3)-flavor symmetry are accounted for. Following a comprehensive examination of the individual quark-sector contributions to octet baryon magnetic moments, numerous opportunities to observe and test the underlying structure of baryons and the nature of chiral nonanalytic behavior in QCD and its quenched variants are discussed. In particular, the valence u-quark contribution to the proton magnetic moment provides the optimal opportunity to directly view nonanalytic behavior associated with the meson cloud of full QCD and the quenched meson cloud of quenched QCD. The u quark in Σ+ provides the best opportunity to display the artifacts of the quenched approximation.Derek B. Leinwebe
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