The role of intracellular trafficking of CdSe/ZnS QDs on their consequent toxicity profile

Nanoparticle interactions with cellular membranes and the kinetics of their transport and localization are important determinants of their functionality and their biological consequences. Understanding these phenomena is fundamental for the translation of such NPs from in vitro to in vivo systems for bioimaging and medical applications. Two CdSe/ZnS quantum dots (QD) with differing surface functionality (NH2 or COOH moieties) were used here for investigating the intracellular uptake and transport kinetics of these QDs.status: publishe

Ancestral Pueblo Archaeology: The Value of Synthesis

Archaeologists working in the Ancestral Pueblo region of the American Southwest have documented variability in sociopolitical and economic complexity, landscape use, community organization, mobility, and violence at a wide range of temporal and spatial scales from AD 500-1700. Recent studies have a strong synthetic orientation, employ methods that track material culture, mobility, and social networks at macroregional scales, and benefit from a renewed engagement with indigenous peoples. Much of this research relies on integrating vast amounts of data from numerous academic and cultural resource management projects and demonstrates the promise of an archaeology that relies on the cumulative acquisition and sharing of data. Given the scale and depth of this research, Ancestral Pueblo archaeology is an exceptional comparative case for archaeologists considering similar processes, especially at fine temporal and wide geographical scales, in ancient farming societies across the globe

Costly Signaling Theory in Archaeology

Why do people engage in seemingly wasteful behaviors and invest in extravagant material displays? Since its introduction into anthropological archaeology two decades ago, costly signaling theory (CST) has been used to provide an answer to this question. With broad origins in biology and social theory, costly signaling theory seeks to provide an evolutionary explanation for why humans engage in seemingly wasteful behaviors. In this chapter, I take stock of costly signaling theory in archaeology by (1) tracing its theoretical origins and history of adoption into anthropological archaeology, (2) highlighting key issues that archaeologists have been wrestling with in order to make CST applicable to the past, (3) discussing the breadth of uses of CST in the recent archaeological literature, and (4) presenting an analytical framework that can make CST more rigorous and in the future. Despite persistent doubts about the explanatory utility of CST, the study of signaling from an evolutionary perspective remains a key aspect of evolutionary archaeology