3,136 research outputs found
Comprehensive characterization of molecular interactions based on nanomechanics
Molecular interaction is a key concept in our understanding of the biological mechanisms of life. Two physical properties change when one molecular partner binds to another. Firstly, the masses combine and secondly, the structure of at least one binding partner is altered, mechanically transducing the binding into subsequent biological reactions. Here we present a nanomechanical micro-array technique for bio-medical research, which not only monitors the binding of effector molecules to their target but also the subsequent effect on a biological system in vitro. This label-free and real-time method directly and simultaneously tracks mass and nanomechanical changes at the sensor interface using micro-cantilever technology. To prove the concept we measured lipid vesicle (approximately 748*10(6) Da) adsorption on the sensor interface followed by subsequent binding of the bee venom peptide melittin (2840 Da) to the vesicles. The results show the high dynamic range of the instrument and that measuring the mass and structural changes simultaneously allow a comprehensive discussion of molecular interactions
Photodissociation and the Morphology of HI in Galaxies
Young massive stars produce Far-UV photons which dissociate the molecular gas
on the surfaces of their parent molecular clouds. Of the many dissociation
products which result from this ``back-reaction'', atomic hydrogen \HI is one
of the easiest to observe through its radio 21-cm hyperfine line emission. In
this paper I first review the physics of this process and describe a simplified
model which has been developed to permit an approximate computation of the
column density of photodissociated \HI which appears on the surfaces of
molecular clouds. I then review several features of the \HI morphology of
galaxies on a variety of length scales and describe how photodissociation might
account for some of these observations. Finally, I discuss several consequences
which follow if this view of the origin of HI in galaxies continues to be
successful.Comment: 18 pages, 7 figures in 8 files, invited review paper for the
conference "Penetrating Bars Through Masks of Cosmic Dust: The Hubble Tuning
Fork Strikes a New Note", South Africa, June 2004. Proceedings to be
published by Kluwer, eds. D.L. Block, K.C. Freeman, I. Puerari, R. Groess, &
E.K. Bloc
B-L Cosmic Strings in Heterotic Standard Models
E_{8} X E_{8} heterotic string and M-theory, when compactified on smooth
Calabi-Yau manifolds with SU(4) vector bundles, can give rise to softly broken
N=1 supersymmetric theories with the exact matter spectrum of the MSSM,
including three right-handed neutrinos and one Higgs-Higgs conjugate pair of
supermultiplets. These vacua have the SU(3)_{C} X SU(2)_{L} X U(1)_{Y} gauge
group of the standard model augmented by an additional gauged U(1)_{B-L}. Their
minimal content requires that the B-L symmetry be spontaneously broken by a
vacuum expectation value of at least one right-handed sneutrino. The soft
supersymmetry breaking operators can induce radiative breaking of the B-L gauge
symmetry with an acceptable B-L/electroweak hierarchy. In this paper, it is
shown that U(1)_{B-L} cosmic strings occur in this context, potentially with
both bosonic and fermionic superconductivity. We present a numerical analysis
that demonstrates that boson condensates can, in principle, form for theories
of this type. However, the weak Yukawa and gauge couplings of the right-handed
sneutrino suggests that bosonic superconductivity will not occur in the
simplest vacua in this context. The electroweak phase transition also disallows
fermion superconductivity, although substantial bound state fermion currents
can exist.Comment: 41 pages, 5 figure
Heterotic Line Bundle Standard Models
In a previous publication, arXiv:1106.4804, we have found 200 models from
heterotic Calabi-Yau compactifications with line bundles, which lead to
standard models after taking appropriate quotients by a discrete symmetry and
introducing Wilson lines. In this paper, we construct the resulting standard
models explicitly, compute their spectrum including Higgs multiplets, and
analyze some of their basic properties. After removing redundancies we find
about 400 downstairs models, each with the precise matter spectrum of the
supersymmetric standard model, with one, two or three pairs of Higgs doublets
and no exotics of any kind. In addition to the standard model gauge group, up
to four Green-Schwarz anomalous U(1) symmetries are present in these models,
which constrain the allowed operators in the four-dimensional effective
supergravity. The vector bosons associated to these anomalous U(1) symmetries
are massive. We explicitly compute the spectrum of allowed operators for each
model and present the results, together with the defining data of the models,
in a database of standard models accessible at
http://www-thphys.physics.ox.ac.uk/projects/CalabiYau/linebundlemodels/index.html.
Based on these results we analyze elementary phenomenological properties. For
example, for about 200 models all dimension four and five proton decay
violating operators are forbidden by the additional U(1) symmetries.Comment: 55 pages, Latex, 3 pdf figure
Ultrametric spaces of branches on arborescent singularities
Let be a normal complex analytic surface singularity. We say that is
arborescent if the dual graph of any resolution of it is a tree. Whenever
are distinct branches on , we denote by their intersection
number in the sense of Mumford. If is a fixed branch, we define when and
otherwise. We generalize a theorem of P{\l}oski concerning smooth germs of
surfaces, by proving that whenever is arborescent, then is an
ultrametric on the set of branches of different from . We compute the
maximum of , which gives an analog of a theorem of Teissier. We show that
encodes topological information about the structure of the embedded
resolutions of any finite set of branches. This generalizes a theorem of Favre
and Jonsson concerning the case when both and are smooth. We generalize
also from smooth germs to arbitrary arborescent ones their valuative
interpretation of the dual trees of the resolutions of . Our proofs are
based in an essential way on a determinantal identity of Eisenbud and Neumann.Comment: 37 pages, 16 figures. Compared to the first version on Arxiv, il has
a new section 4.3, accompanied by 2 new figures. Several passages were
clarified and the typos discovered in the meantime were correcte
Quantum Holographic Encoding in a Two-dimensional Electron Gas
The advent of bottom-up atomic manipulation heralded a new horizon for
attainable information density, as it allowed a bit of information to be
represented by a single atom. The discrete spacing between atoms in condensed
matter has thus set a rigid limit on the maximum possible information density.
While modern technologies are still far from this scale, all theoretical
downscaling of devices terminates at this spatial limit. Here, however, we
break this barrier with electronic quantum encoding scaled to subatomic
densities. We use atomic manipulation to first construct open
nanostructures--"molecular holograms"--which in turn concentrate information
into a medium free of lattice constraints: the quantum states of a
two-dimensional degenerate Fermi gas of electrons. The information embedded in
the holograms is transcoded at even smaller length scales into an atomically
uniform area of a copper surface, where it is densely projected into both two
spatial degrees of freedom and a third holographic dimension mapped to energy.
In analogy to optical volume holography, this requires precise amplitude and
phase engineering of electron wavefunctions to assemble pages of information
volumetrically. This data is read out by mapping the energy-resolved electron
density of states with a scanning tunnelling microscope. As the projection and
readout are both extremely near-field, and because we use native quantum states
rather than an external beam, we are not limited by lensing or collimation and
can create electronically projected objects with features as small as ~0.3 nm.
These techniques reach unprecedented densities exceeding 20 bits/nm2 and place
tens of bits into a single fermionic state.Comment: Published online 25 January 2009 in Nature Nanotechnology; 12 page
manuscript (including 4 figures) + 2 page supplement (including 1 figure);
supplementary movie available at http://mota.stanford.ed
A Global SU(5) F-theory model with Wilson line breaking
We engineer compact SU(5) Grand Unified Theories in F-theory in which
GUT-breaking is achieved by a discrete Wilson line. Because the internal gauge
field is flat, these models avoid the high scale threshold corrections
associated with hypercharge flux. Along the way, we exemplify the
`local-to-global' approach in F-theory model building and demonstrate how the
Tate divisor formalism can be used to address several challenges of extending
local models to global ones. These include in particular the construction of
G-fluxes that extend non-inherited bundles and the engineering of U(1)
symmetries. We go beyond chirality computations and determine the precise
(charged) massless spectrum, finding exactly three families of quarks and
leptons but excessive doublet and/or triplet pairs in the Higgs sector
(depending on the example) and vector-like exotics descending from the adjoint
of SU(5)_{GUT}. Understanding why vector-like pairs persist in the Higgs sector
without an obvious symmetry to protect them may shed light on new solutions to
the mu problem in F-theory GUTs.Comment: 95 pages (71 pages + 1 Appendix); v2 references added, minor
correction
Non-supersymmetric heterotic model building
We investigate orbifold and smooth Calabi-Yau compactifications of the
non-supersymmetric heterotic SO(16)xSO(16) string. We focus on such Calabi-Yau
backgrounds in order to recycle commonly employed techniques, like index
theorems and cohomology theory, to determine both the fermionic and bosonic 4D
spectra. We argue that the N=0 theory never leads to tachyons on smooth
Calabi-Yaus in the large volume approximation. As twisted tachyons may arise on
certain singular orbifolds, we conjecture that such tachyonic states are lifted
in the full blow-up. We perform model searches on selected orbifold geometries.
In particular, we construct an explicit example of a Standard Model-like theory
with three generations and a single Higgs field.Comment: 1+30 pages latex, 11 tables; v2: references and minor revisions
added, matches version published in JHE
Work related musculoskeletal injuries sustained by Australian osteopaths: qualitative analysis of effects on practitioner health, clinical practice, and patient care
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