1,404 research outputs found
AdS/BCFT Correspondence for Higher Curvature Gravity: An Example
We consider the effects of higher curvature terms on a holographic dual
description of boundary conformal field theory. Specifically, we consider
three-dimensional gravity with a specific combination of Ricci tensor square
and curvature scalar square, so called, new massive gravity. We show that a
boundary entropy and an entanglement entropy are given by similar expression
with those of the Einstein gravity case when we introduce an {\it effective}
Newton's constant and an {\it effective} cosmological constant. We also show
that the holographic g-theorem still holds in this extension, and we give some
comments about the central charge dependence of boundary entropy in the
holographic construction. In the same way, we consider new type black holes and
comment on the boundary profile. Moreover, we reproduce these results through
auxiliary field formalism in this specific higher curvature gravity.Comment: 27pages, minor corrections, accepted in JHE
Targeted Assembly of Short Sequence Reads
As next-generation sequence (NGS) production continues to increase, analysis is becoming a significant bottleneck. However, in situations where information is required only for specific sequence variants, it is not necessary to assemble or align whole genome data sets in their entirety. Rather, NGS data sets can be mined for the presence of sequence variants of interest by localized assembly, which is a faster, easier, and more accurate approach. We present TASR, a streamlined assembler that interrogates very large NGS data sets for the presence of specific variants, by only considering reads within the sequence space of input target sequences provided by the user. The NGS data set is searched for reads with an exact match to all possible short words within the target sequence, and these reads are then assembled strin-gently to generate a consensus of the target and flanking sequence. Typically, variants of a particular locus are provided as different target sequences, and the presence of the variant in the data set being interrogated is revealed by a successful assembly outcome. However, TASR can also be used to find unknown sequences that flank a given target. We demonstrate that TASR has utility in finding or confirming ge-nomic mutations, polymorphism, fusion and integration events. Targeted assembly is a powerful method for interrogating large data sets for the presence of sequence variants of interest. TASR is a fast, flexible and easy to use tool for targeted assembly
Visualizing landscapes of the superconducting gap in heterogeneous superconductor thin films: geometric influences on proximity effects
The proximity effect is a central feature of superconducting junctions as it
underlies many important applications in devices and can be exploited in the
design of new systems with novel quantum functionality. Recently, exotic
proximity effects have been observed in various systems, such as
superconductor-metallic nanowires and graphene-superconductor structures.
However, it is still not clear how superconducting order propagates spatially
in a heterogeneous superconductor system. Here we report intriguing influences
of junction geometry on the proximity effect for a 2D heterogeneous
superconductor system comprised of 2D superconducting islands on top of a
surface metal. Depending on the local geometry, the superconducting gap induced
in the surface metal region can either be confined to the boundary of the
superconductor, in which the gap decays within a short distance (~ 15 nm), or
can be observed nearly uniformly over a distance of many coherence lengths due
to non-local proximity effects.Comment: 17 pages, 4 figure
AdS Black Hole Solutions in the Extended New Massive Gravity
We have obtained (warped) AdS black hole solutions in the three dimensional
extended new massive gravity. We investigate some properties of black holes and
obtain central charges of the two dimensional dual CFT. To obtain the central
charges, we use the relation between entropy and temperature according to the
AdS/CFT dictionary. For AdS black holes, one can also use the central charge
function formalism which leads to the same results.Comment: 24pages, some organization corrected, minor corrections, references
added, final published versio
Evoked potentials in the Atlantic cod following putatively innocuous and putatively noxious electrical stimulation: a minimally invasive approach
Aspects of peripheral and central nociception
have previously been studied through recording of
somatosensory evoked potentials (SEPs) to putative
noxious stimuli in specific brain regions in a few
freshwater fish species. In the present study, we
describe a novel, minimally invasive method for
recording SEPs from the central nervous system of the
Atlantic cod (Gadus morhua). Cutaneous electric
stimulation of the tail in 15 fish elicited SEPs at all
stimulus intensities (2, 5, 10 and 20 mA) with
quantitative properties corresponding to stimulus
intensity. In contrast to previous fish studies, the
methodological approach used in Atlantic cod in the
current study uncovered a number of additional
responses that could originate from multiple brain
regions. Several of these responses were specific to
stimulation at the highest stimulus intensities, possibly
representing qualitative differences in central processing
between somatosensory and nociceptive stimuli
AdS_3/LCFT_2 - Correlators in Cosmological Topologically Massive Gravity
For cosmological topologically massive gravity at the chiral point we
calculate momentum space 2- and 3-point correlators of operators in the
postulated dual CFT on the cylinder. These operators are sourced by the bulk
and boundary gravitons. Our correlators are fully consistent with the proposal
that cosmological topologically massive gravity at the chiral point is dual to
a logarithmic CFT. In the process we give a complete classification of
normalizable and non-normalizeable left, right and logarithmic solutions to the
linearized equations of motion in global AdS_3.Comment: 39 pages + appendices, 1 eps figure, v2: minor changes in text in
4.1.2, corrected typo in (2.31
Access to the next wave of biologic therapies (Abatacept and Tocilizumab) for the treatment of rheumatoid arthritis in England and Wales: Addressing treatment outside the current NICE guidance
Patients in England and Wales with rheumatoid arthritis (RA) receive treatment from the National Health Service (NHS) with therapies approved by the European Medicines Agency (EMA), under guidance from the National Institute for Health and Clinical Excellence (NICE). This document overviews the current NICE guidelines for the treatment of RA and identifies scenarios when such guidance may not represent the optimum management strategy for individual patients. Specifically, we consider the use of tocilizumab or abatacept as the most appropriate treatments for some patients. In such scenarios, it may be possible for the clinician to secure access to the required therapy through an application procedure known as an ‘individual funding request’, the process of which is described in detail here. At present, it is unclear the extent to which the proposed reform of the NHS will affect the role of NICE in providing guidance and setting standards of care. Until the full impact of the proposed changes are realized, individual funding requests will remain a valuable way of securing the optimal treatment for all patients suffering from RA
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