1,909 research outputs found
Monitoring of lung edema by microwave reflectometry during lung ischemia-reperfusion injury in vivo
It is still unclear whether lung edema can be monitored by microwave reflectometry and whether the measured changes in lung dry matter content (DMC) are accompanied by changes in PaO(2) and in pro-to anti-inflammatory cytokine expression (IFN-gamma and IL-10). Right rat lung hili were cross-clamped at 37 degrees C for 0, 60, 90 or 120 min ischemia followed by 120 min reperfusion. After 90 min (DMC: 15.9 +/- 1.4%; PaO(2): 76.7 +/- 18 mm Hg) and 120 min ischemia (DMC: 12.8 +/- 0.6%; PaO(2): 43 +/- 7 mm Hg), a significant decrease in DMC and PaO(2) throughout reperfusion compared to 0 min ischemia (DMC: 19.5 +/- 1.11%; PaO(2): 247 +/- 33 mm Hg; p < 0.05) was observed. DMC and PaO(2) decreased after 60 min ischemia but recovered during reperfusion (DMC: 18.5 +/- 2.4%; PaO(2) : 173 +/- 30 mm Hg). DMC values reflected changes on the physiological and molecular level. In conclusion, lung edema monitoring by microwave reflectometry might become a tool for the thoracic surgeon. Copyright (c) 2006 S. Karger AG, Basel
Anomaly and a QCD-like phase diagram with massive bosonic baryons
We study a strongly coupled lattice gauge theory with two flavors of
quarks, invariant under an exact symmetry which is the same as QCD with
two flavors of quarks without an anomaly. The model also contains a coupling
that can be used to break the symmetry and thus mimic the QCD
anomaly. At low temperatures and small baryon chemical potential
the model contains massless pions and massive bosonic baryons similar to QCD
with an even number of colors. In this work we study the phase
diagram of the model and show that it contains three phases : (1) A chirally
broken phase at low and , (2) a chirally symmetric baryon superfluid
phase at low and high , and (3) a symmetric phase at high . We
find that the nature of the finite temperature chiral phase transition and in
particular the location of the tricritical point that seperates the first order
line from the second order line is affected significantly by the anomaly.Comment: 22 pages, 16 figures, 5 tables, references adde
QCD-like theories at nonzero temperature and density
We investigate the properties of hot and/or dense matter in QCD-like theories
with quarks in a (pseudo)real representation of the gauge group using the
Nambu-Jona-Lasinio model. The gauge dynamics is modeled using a simple lattice
spin model with nearest-neighbor interactions. We first keep our discussion as
general as possible, and only later focus on theories with adjoint quarks of
two or three colors. Calculating the phase diagram in the plane of temperature
and quark chemical potential, it is qualitatively confirmed that the critical
temperature of the chiral phase transition is much higher than the
deconfinement transition temperature. At a chemical potential equal to half of
the diquark mass in the vacuum, a diquark Bose-Einstein condensation (BEC)
phase transition occurs. In the two-color case, a Ginzburg-Landau expansion is
used to study the tetracritical behavior around the intersection point of the
deconfinement and BEC transition lines, which are both of second order. We
obtain a compact expression for the expectation value of the Polyakov loop in
an arbitrary representation of the gauge group (for any number of colors),
which allows us to study Casimir scaling at both nonzero temperature and
chemical potential.Comment: JHEP class, 31 pages, 7 eps figures; v2: error in Eq. (3.11) fixed,
two references added; matches published versio
Adsorption of Methylmercury onto Geobacter bemidijensis Bem
The anaerobic bacterium Geobacter bemidijensis Bem has the unique ability to both produce and degrade methylmercury (MeHg). While the adsorption of MeHg onto bacterial surfaces can affect the release of MeHg into aquatic environments as well as the uptake of MeHg for demethylation, the binding of MeHg to the bacterial envelope remains poorly understood. In this study, we quantified the adsorption of MeHg onto G. bemidijensis and applied X-ray absorption spectroscopy (XAS) to elucidate the mechanism of MeHg binding. The results showed MeHg adsorption onto G. bemidijensis cell surfaces was rapid and occurred via complexation to sulfhydryl functional groups. Titration experiments yielded cell surface sulfhydryl concentrations of 3.8 ± 0.2 μmol/g (wet cells). A one-site adsorption model with MeHg binding onto sulfhydryl sites provided excellent fits to adsorption isotherms conducted at different cell densities. The log K binding constant of MeHg onto the sulfhydryl sites was determined to be 10.5 ± 0.4. These findings provide a quantitative framework to describe MeHg binding onto bacterial cell surfaces and elucidate the importance of bacterial cells as possible carriers of adsorbed MeHg in natural aquatic systems
Antiglucocorticoid RU38486 reduces net protein catabolism in experimental acute renal failure
BACKGROUND: In acute renal failure, a pronounced net protein catabolism occurs that has long been associated with corticoid action. By competitively blocking the glucocorticoid receptor with the potent antiglucocorticoid RU 38486, the present study addressed the question to what extent does corticoid action specific to uremia cause the observed muscle degradation, and does inhibition of glucocorticoid action reduce the protein wasting? METHODS: RU 38486 was administered in a dose of 50 mg/kg/24 h for 48 h after operation to fasted bilaterally nephrectomized (BNX) male adult Wistar rats and sham operated (SHAM) controls. Protein turnover was evaluated by high performance liquid chromatography (HPLC) of amino acid efflux in sera from isolated perfused hindquarters of animals treated with RU 38486 versus untreated controls. RESULTS: Administration of RU 38486 reduces the total amino acid efflux (TAAE) by 18.6% in SHAM and 15.6% in BNX and efflux of the indicator of net protein turnover, phenylalanine (Phe) by 33.3% in SHAM and 13% in BNX animals as compared to the equally operated, but untreated animals. However, the significantly higher protein degradation observed in BNX (0.6 ± 0.2 nmol/min/g muscle) versus SHAM (0.2 ± 0.1 nmol/min/g muscle) rats, as demonstrated by the marker of myofribrillar proteolytic rate, 3-Methylhistidine (3 MH) remains unaffected by administration of RU 38486 (0.5 ± 0.1 v. 0.2 ± 0.1 nmol/min/g muscle in BNX v. SHAM). CONCLUSION: RU 38486 does not act on changes of muscular protein turnover specific to uremia but reduces the effect of stress- stimulated elevated corticosterone secretion arising from surgery and fasting. A potentially beneficial effect against stress- induced catabolism in severe illness can be postulated that merits further study
The order of the quantum chromodynamics transition predicted by the standard model of particle physics
We determine the nature of the QCD transition using lattice calculations for
physical quark masses. Susceptibilities are extrapolated to vanishing lattice
spacing for three physical volumes, the smallest and largest of which differ by
a factor of five. This ensures that a true transition should result in a
dramatic increase of the susceptibilities.No such behaviour is observed: our
finite-size scaling analysis shows that the finite-temperature QCD transition
in the hot early Universe was not a real phase transition, but an analytic
crossover (involving a rapid change, as opposed to a jump, as the temperature
varied). As such, it will be difficult to find experimental evidence of this
transition from astronomical observations.Comment: 7 pages, 4 figure
Scaling laws near the conformal window of many-flavor QCD
We derive universal scaling laws for physical observables such as the
critical temperature, the chiral condensate, and the pion decay constant as a
function of the flavor number near the conformal window of many-flavor QCD in
the chiral limit. We argue on general grounds that the associated critical
exponents are all interrelated and can be determined from the critical exponent
of the running gauge coupling at the Caswell-Banks-Zaks infrared fixed point.
We illustrate our findings with the aid of nonperturbative functional
Renormalization Group (RG) calculations and low-energy QCD models.Comment: 18 pages, 4 figures, references added and discussion expanded
(matches JHEP version
Tycho Brahe's 1572 supernova as a standard type Ia explosion revealed from its light echo spectrum
Type Ia supernovae (SNe Ia) are thermonuclear explosions of white dwarf stars
in close binary systems. They play an important role as cosmological distance
indicators and have led to the discovery of the accelerated expansion of the
Universe. Among the most important unsolved questions are how the explosion
actually proceeds and whether accretion occurs from a companion or via the
merging of two white dwarfs. Tycho Brahe's supernova of 1572 (SN 1572) is
thought to be one of the best candidates for a SN Ia in the Milky Way. The
proximity of the SN 1572 remnant has allowed detailed studies, such as the
possible identification of the binary companion, and provides a unique
opportunity to test theories of the explosion mechanism and the nature of the
progenitor. The determination of the yet unknown exact spectroscopic type of SN
1572 is crucial to relate these results to the diverse population of SNe Ia.
Here we report an optical spectrum of Tycho Brahe's supernova near maximum
brightness, obtained from a scattered-light echo more than four centuries after
the direct light of the explosion swept past Earth. We find that SN 1572
belongs to the majority class of normal SNe Ia. The presence of a strong Ca II
IR feature at velocities exceeding 20,000 km/s, which is similar to the
previously observed polarized features in other SNe Ia, suggests asphericity in
SN 1572.Comment: 15 pages, 3 figures - accepted for publication in Natur
Visual ecology of aphids – a critical review on the role of colours in host finding
We review the rich literature on behavioural responses of aphids (Hemiptera: Aphididae) to stimuli of different colours. Only in one species there are adequate physiological data on spectral sensitivity to explain behaviour crisply in mechanistic terms.
Because of the great interest in aphid responses to coloured targets from an evolutionary, ecological and applied perspective, there is a substantial need to expand these studies to more species of aphids, and to quantify spectral properties of stimuli rigorously. We show that aphid responses to colours, at least for some species, are likely based on a specific colour opponency mechanism, with positive input from the green domain of the spectrum and negative input from the blue and/or UV region.
We further demonstrate that the usual yellow preference of aphids encountered in field experiments is not a true colour preference but involves additional brightness effects. We discuss the implications for agriculture and sensory ecology, with special respect to the recent debate on autumn leaf colouration. We illustrate that recent evolutionary theories concerning aphid–tree interactions imply far-reaching assumptions on aphid responses to colours
that are not likely to hold. Finally we also discuss the
implications for developing and optimising strategies
of aphid control and monitoring
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