7,911 research outputs found

    The Turk and the Yankee: A Cross-Cultural Comparison between Turkish and American Managers

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    With Turkey’s developing role as a lead nation among emerging markets, the field of cross-cultural management becomes a key contributor to the interactions between Turkish and American professionals in the workplace. This study uses models of national cultural differences based primarily on the findings of Hofstede (1984), but it also incorporates those of Trompenaars and Hampden-Turner (1998) and the GLOBE project (2002), resulting in a comparative cross-cultural management analysis. In combining both academic theory and actual international experience, this paper illustrates that, through effective cross-cultural management, profound understanding and harmony can exist between international managers

    Notes on a series of cases of sore throat arising from a milk-borne infection

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    Nucleolar Stress Due to Depletion of Nopp140 in Drosophila melanogaster

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    Nucleolar stress results when ribosome biogenesis is disrupted. An excellent example is the human Treacher Collins syndrome in which the loss of the nucleolar chaperone, Treacle, leads to p53-dependent apoptosis in embryonic neural crest cells, and ultimately to craniofacial birth defects. We show that depletion of the related nucleolar and Cajal body phospho-protein, Nopp140, in Drosophila melanogaster led to nucleolar stress and eventual lethality when multiple tissues were depleted of Nopp140 by RNAi. We used TEM, immuno-blot analysis, and metabolic protein labeling to show the loss of ribosomes. Targeted loss of Nopp140 only in larval wing discs caused apoptosis, which eventually led to defects in the adult wings. These defects were not rescued by a p53 gene deletion, as the craniofacial defects were in the murine model of TCS, thus suggesting that apoptosis caused by nucleolar stress in Drosophila is induced by a p53-independent mechanism. Loss of Nopp140 in larval polyploid midgut cells induced premature autophagy as marked by the accumulation of mCherry-ATG8a into autophagic vesicles. We also found elevated phenoloxidase A3 levels in whole larval lysates and within the hemolymph of Nopp140-depleted larvae, coincident with the appearance of melanotic tumors. The occurrence of apoptosis, autophagy, and phenoloxidase A3 release to the hemolymph upon nucleolar stress correlated well with the activation of JNK in Nopp140-depleted larvae. Nopp140 is considered a ribosome assembly factor, but its precise functions remain unknown. To approach this problem, we deleted the Nopp140 gene in Drosophila using FLP-FRT recombination. Genomic PCR, RT-PCR, and immunofluorescence microscopy confirmed the loss of Nopp140, its mRNA, and protein products. Nopp140-/- larvae arrested in the second instar stage and died within 8 days. While nucleoli appeared intact in Nopp140-/- cells, the C/D snoRNP methyl-transferase, fibrillarin, redistributed to the nucleoplasm in variable amounts; RT-PCRs showed that 2’-O-methylation of rRNA in Nopp140-/- cells was reduced. Ultra structural analysis showed that Nopp140-/- cells were deficient in cytoplasmic ribosomes, but instead contained abnormal electron dense cytoplasmic granules. Furthermore, metabolic labeling showed a significant drop in protein translation. We believe the phenotypes described here define novel intracellular ribosomopathies

    The structure and experience of childhood and adolescence: an anthropological approach to socialization

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    Becoming human is becoming social and this thesis explores the nature of the socialization process through the presentation of material derived from anthropological fieldwork with adolescents in the north-east of England. In contrast to more traditional approaches, it suggests that an adequate understanding of how socialization occurs, rather than merely what occurs, can only be achieved through focusing directly upon the experiences of those undergoing the socialization process itself and upon how they articulate these experiences. In this respect the adoption of the anthropological fieldwork technique of participant observation is shown to be critical. It allows access to the experience of socialization, rather than simply its later effects, through exploring the temporal rhythms of the socialization process made manifest in life-cycle categories. These categories, it is argued, structure the progressive awareness and understanding reached by children as they mature through providing them with the time and space for the creation of their own culture - the culture of ' doing nothing '.With the theoretical insights gained from a semantic approach to the study of social life this culture is interpreted as a conceptual context whereby children themselves conduct their own rite de passage to adulthood. Through analysis of the concepts of time and space; linguistic performance and nickname usage; the body as an expressive medium and the social construction of gender, a distinctive cultural style emerges which represents an active deconstruction and reinterpretation of adult social order by children. This pervasive style of ' doing nothing ' provides a single underlying form for a multiplicity of contents : motifs of transformation constantly reappear in different domains and provide a coherent semantic system through which children gain knowledge of their own futures. Within this approach, then, socialization is no passive imitation ; rather, it emerges as an active and creative learning process in and about the world

    Action of Thionyl Chloride on Diacetone-Glucose

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    Diacetone-glucose was treated with thionyl chloride in hopes of replacing the free hydroxy group by chlorine. The sodium salt of diacetone-glucose (and other diacetonehexoses) in inert solvents, reacts instantaneously with thionyl chloride. The reaction product is apparently the di-(diacetone-glucose)-ester of sulfurous or sulfonic acid. One fraction has been obtained crystalline but no analysis was attempted due to the small yields. The product reacts with hydrazine to form the 3-hydrazino-diacetone-glucose which would indicate a structure analogous to that of the 3-toluol-sulfono-diacetone-glucose

    Personal and corporate spiritual growth through the discipline of silence and solitude

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    https://place.asburyseminary.edu/ecommonsatsdissertations/1771/thumbnail.jp
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