Una teoría de la intervención delictiva

En el presente estudio se desarrolla una particular teoría de la intervención delictiva, que se fundamenta en la distinción entre deberes negativos (que obligan a los sujetos a organizar su ámbito de organización de manera que no se produzcan riesgos para los derechos de los demás) y deberes positivos (que obligan al sujeto de manera activa y especial a una específica obligación de hacer). En ambos casos, se presentan problemas de intervención delictiva que son de extraordinaria relevancia para la Dogmática penal y que son desarrollados en profundidad en este trabajo.In the present study a particular theory of criminal procedure is developed, which is based on the distinction between negative duties (requiring individuals to organise their field of organisation so that no risks are caused to third parties) and positive duties (which oblige individuals in an active and special way to specific obligations of duty). In both cases problems of criminal intervention of extraordinary relevante for criminal dogmatic are presented and developed in this paper

Principios y límites de la justificación

Este artículo aborda el tema atinente a los principios y límites que rigen la justificación del hecho desde la perspectiva tanto del Derecho interno como, en particular, de los estándares fijados por el Derecho Internacional –en especial, los protocolos de Ginebra (i, ii, iii y iv)–, contrastando tal estado de cosas con un análisis basado en la filosofía del Derecho, a fin de resolver una cuestión fundamental: cuál es el límite que rige la actuación del Estado en situaciones en las que, fundamentalmente en el escenario de una guerra civil, las acciones defensivas estatales resultan aptas para producir un daño colateral y cuál es el alcance del deber del Estado de proteger positivamente a las eventuales víctimas

La pena estatal : significado y finalidad

Divulgação dos SUMÁRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito à lei de Direitos Autorais, não disponibilizamos a obra na íntegra.Localização na estante: 343.2 J25

Concurrencia de riegos : curso lesivo y curso hipotético en el derecho penal

Fil: Günter, Jakobs. Universidad de Bonn. Facultad de Derecho y Ciencias Políticas. Cátedras Derecho penal y Filosofía del Derecho. Bonn, AlemaniaTraducción del articulo Riaiknkonkurrenz-Schadevuverlauf und Vefluuhhypothue im Strqfl'echt (Fanchrífi für Karl Lackner. Walter de Gruyter. Berlin-New York. 1987. p. 53-75) realizada por Carlos J. Suárez González (profesor de Derecho Penal en la Universidad Autónoma de Madrid) y Manuel Cancio Melia (Universidad Autónoma de Madrid

La prohibición de regreso en derecho penal

Divulgação dos SUMÁRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito à lei de Direitos Autorais, não disponibilizamos a obra na íntegra. STJ0006676

Taste-immune associative learning amplifies immunopharmacological effects and attenuates disease progression in a rat glioblastoma model

Mechanistic target of rapamycin (mTOR)-signaling is one key driver of glioblastoma (GBM), facilitating tumor growth by promoting the shift to an anti-inflammatory, pro-cancerogenic microenvironment. Even though mTOR inhibitors such as rapamycin (RAPA) have been shown to interfere with GBM disease progression, frequently chaperoned toxic drug side effects urge the need for developing alternative or supportive treatment strategies. Importantly, previous work document that taste-immune associative learning with RAPA may be utilized to induce learned pharmacological placebo responses in the immune system. Against this background, the current study aimed at investigating the potential efficacy of a taste-immune associative learning protocol with RAPA in a syngeneic GBM rat model. Following repeated pairings of a novel gustatory stimulus with injections of RAPA, learned immune-pharmacological effects could be retrieved in GBM-bearing animals when re-exposed to the gustatory stimulus together with administering 10 % amount of the initial drug dose (0.5 mg/kg). These inhibitory effects on tumor growth were accompanied by an up-regulation of central and peripheral pro-inflammatory markers, suggesting that taste-immune associative learning with RAPA promoted the development of a pro-inflammatory anti-tumor microenvironment that attenuated GBM tumor growth to an almost identical outcome as obtained after 100 % (5 mg/kg) RAPA treatment. Together, our results confirm the applicability of taste-immune associative learning with RAPA in animal disease models where mTOR overactivation is one key driver. This proof-of-concept study may also be taken as a role model for implementing learning protocols as alternative or supportive treatment strategy in clinical settings, allowing the reduction of required drug doses and side effects without losing treatment efficacy

Organotypic Culture of Physiologically Functional Adult Mammalian Retinas

BACKGROUND: The adult mammalian retina is an important model in research on the central nervous system. Many experiments require the combined use of genetic manipulation, imaging, and electrophysiological recording, which make it desirable to use an in vitro preparation. Unfortunately, the tissue culture of the adult mammalian retina is difficult, mainly because of the high energy consumption of photoreceptors. METHODS AND FINDINGS: We describe an interphase culture system for adult mammalian retina that allows for the expression of genes delivered to retinal neurons by particle-mediated transfer. The retinas retain their morphology and function for up to six days— long enough for the expression of many genes of interest—so that effects upon responses to light and receptive fields could be measured by patch recording or multielectrode array recording. We show that a variety of genes encoding pre- and post-synaptic marker proteins are localized correctly in ganglion and amacrine cells. CONCLUSIONS: In this system the effects on neuronal function of one or several introduced exogenous genes can be studied within intact neural circuitry of adult mammalian retina. This system is flexible enough to be compatible with genetic manipulation, imaging, cell transfection, pharmacological assay, and electrophysiological recordings