Brucellose du lièvre en France Identification bactériologique des deux premiers cas en Picardie

Jacotot Henri, Vallée A., Barrière J. Brucellose du Lièvre en France. Identification bactériologique des deux premiers cas en Picardie. In: Bulletin de l'Académie Vétérinaire de France tome 104 n°5, 1951. pp. 283-285

Quelques données sur l’infection du bétail français par Vibrio fœtus

Jacotot Henri, Gallut J., Vallée A. Quelques données sur l’infection du bétail français par Vibrio fœtus. In: Bulletin de l'Académie Vétérinaire de France tome 107 n°4, 1954. pp. 153-158

Un cas particulier d'allergie infectieuse, la sensibilisation du porc à l'antigène de l'encéphalo-myélite euzootique

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Transmission expérimentale de l'encéphalo-myélite enzootique des porcs par inoculation sous-cutanée

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Intérêt des contrôles histopathologiques dans le dépistage des maladies des poissons Application à la Salmoniculture

Levaditi J. C., Besse P., Kinkelin Pierre de, Guillon J. C., Jacotot H. Intérêt des contrôles histopathologiques dans le dépistage des maladies des poissons. Application à la salmoniculture. In: Bulletin de l'Académie Vétérinaire de France tome 118 n°5, 1965. pp. 173-183

HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase

The Trans-activator protein (Tat) of human immunodeficiency virus (HIV) is a pleiotropic protein involved in different aspects of AIDS pathogenesis. As a number of viral proteins Tat is suspected to disturb mitochondrial function. We prepared pure synthetic full-length Tat by native chemical ligation (NCL), and Tat peptides, to evaluate their direct effects on isolated mitochondria. Submicromolar doses of synthetic Tat cause a rapid dissipation of the mitochondrial transmembrane potential (ΔΨm) as well as cytochrome c release in mitochondria isolated from mouse liver, heart, and brain. Accordingly, Tat decreases substrate oxidation by mitochondria isolated from these tissues, with oxygen uptake being initially restored by adding cytochrome c. The anion-channel inhibitor 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid (DIDS) protects isolated mitochondria against Tat-induced mitochondrial membrane permeabilization (MMP), whereas ruthenium red, a ryanodine receptor blocker, does not. Pharmacologic inhibitors of the permeability transition pore, Bax/Bak inhibitors, and recombinant Bcl-2 and Bcl-XL proteins do not reduce Tat-induced MMP. We finally observed that Tat inhibits cytochrome c oxidase (COX) activity in disrupted mitochondria isolated from liver, heart, and brain of both mouse and human samples, making it the first described viral protein to be a potential COX inhibitor

Correlation between HIV viral load and aminotransferases as liver damage markers in HIV infected naive patients: a concordance cross-sectional study

Abnormalities in liver function tests could be produced exclusively by direct inflammation in hepatocytes, caused by the human immunodeficiency virus (HIV). Mechanisms by which HIV causes hepatic damage are still unknown. Our aim was to determine the correlation between HIV viral load, and serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) as markers of hepatic damage in HIV naive infected patients

Atmospheric-Pressure Plasma Jet Induces Apoptosis Involving Mitochondria via Generation of Free Radicals

The plasma jet has been proposed as a novel therapeutic method for anticancer treatment. However, its biological effects and mechanism of action remain elusive. Here, we investigated its cell death effects and underlying molecular mechanisms, using air and N2 plasma jets from a micro nozzle array. Treatment with air or N2 plasma jets caused apoptotic death in human cervical cancer HeLa cells, simultaneously with depolarization of mitochondrial membrane potential. In addition, the plasma jets were able to generate reactive oxygen species (ROS), which function as surrogate apoptotic signals by targeting the mitochondrial membrane potential. Antioxidants or caspase inhibitors ameliorated the apoptotic cell death induced by the air and N2 plasma jets, suggesting that the plasma jet may generate ROS as a proapoptotic cue, thus initiating mitochondria-mediated apoptosis. Taken together, our data suggest the potential employment of plasma jets as a novel therapy for cancer