A Study of the Effect of Errors in Measurement of Velocity and Flight-Path Angle on the Guidance of a Space Vehicle Approaching the Earth

An analysis was made of the guidance of a space vehicle approaching the earth at supercircular velocity through an entrance corridor containing a desired perigee altitude. Random errors were assumed in the measurement of velocity and flight-path angle and in obtaining the desired thrust impulse. The method described in NASA Technical Note D-191 of scheduling corrections at different values of the angle between perigee and the vehicle's position vector and a slight modification of this method were investigated as a means of correcting perigee altitude when the vehicle's predicted position was at programmed correction points not within a specified deadband about the desired perigee altitude. The study showed that modifying the angular method of NASA Technical Note D-191 by adding another correction near the initial point did not improve the efficiency and accuracy of the angular method. It was found that in some cases the use of a correction procedure which included a deadband could be more costly in total corrective velocity than a procedure which neglected the deadband. This was especially true if a large degree of confidence was required in the total corrective velocity. It was apparent from the results that a correction with a deadband limit in the guidance scheme was more sensitive to the initial conditions, the corrective procedure, the deadband, and the degree of confidence required than a correction without a deadband limit

Marxian and Weberian theory as explanations of the effects of industrialization on town development: A case study; Denison, Texas.

While a great deal of historical literature has concentrated on the effects of industrialization on town development, most of the accounts relate to the introduction of industrialization into an established town. This study attempts to analyze, in sociological terms, the effects of industrialization (in this case, the emergence of the railroad) on the social structure of Denison, Texas which was created by industrialization. It is an attempt to combine Marxian and Weberian theory to produce a multi-dimensional theory that can explain town development without the usual economic bias as evident in most contemporary theory. This study proceeds on the assumption that the social order of a newly formed community is not based solely on economic factors. While economic considerations were important for the town of the study, social stability of the town was maintained by other “non-economic” elements. The purpose of the study is to construct a composite theory that can be utilized to analyze town development. The thrust is not the creation of new theory, rather it attempts to combine existing “classical” theories to present a balanced and, to an extent, “objective” explanation of community development. Adding the social aspects of Weber's theory to Marx's theory results in a theory that limits the economic bias associated with pure Marxian theory

Why Do Only Some Galaxy Clusters Have Cool Cores?

Flux-limited X-ray samples indicate that about half of rich galaxy clusters have cool cores. Why do only some clusters have cool cores while others do not? In this paper, cosmological N-body + Eulerian hydrodynamic simulations, including radiative cooling and heating, are used to address this question as we examine the formation and evolution of cool core (CC) and non-cool core (NCC) clusters. These adaptive mesh refinement simulations produce both CC and NCC clusters in the same volume. They have a peak resolution of 15.6 h^{-1} kpc within a (256 h^{-1} Mpc)^3 box. Our simulations suggest that there are important evolutionary differences between CC clusters and their NCC counterparts. Many of the numerical CC clusters accreted mass more slowly over time and grew enhanced cool cores via hierarchical mergers; when late major mergers occurred, the CC's survived the collisions. By contrast, NCC clusters experienced major mergers early in their evolution that destroyed embryonic cool cores and produced conditions that prevented CC re-formation. As a result, our simulations predict observationally testable distinctions in the properties of CC and NCC beyond the core regions in clusters. In particular, we find differences between CC versus NCC clusters in the shapes of X-ray surface brightness profiles, between the temperatures and hardness ratios beyond the cores, between the distribution of masses, and between their supercluster environs. It also appears that CC clusters are no closer to hydrostatic equilibrium than NCC clusters, an issue important for precision cosmology measurements.Comment: 17 emulateapj pages, 17 figures, replaced with version accepted to Ap

A catalog of Nearby Poor Clusters of Galaxies

A catalog of 732 optically selected, nearby poor clusters of galaxies covering the entire sky north of $\rm -3^{\circ}$ declination is presented. The poor clusters, called WBL clusters, were identified as concentrations of 3 or more galaxies with photographic magnitudes brighter than 15.7, possessing a galaxy surface overdensity of $10^{4/3}$. These criteria are consistent with those used in the identification of the original Yerkes poor clusters, and this new catalog substantially increases the sample size of such objects. These poor clusters cover the entire range of galaxy associations up to and including Abell clusters, systematically including poor and rich galaxy systems spanning over three orders of magnitude in the cluster mass function. As a result, this new catalog contains a greater diversity of richness and structures than other group catalogs, such as the Hickson or Yerkes catalogs. The information on individual galaxies includes redshifts and cross-references to other galaxy catalogs. The entries for the clusters include redshift (where available) and cross-references to other group and cluster catalogs.Comment: 27 pages, 7 figures, + one 20-page landscape table, accepted for publication in A

Redshifts and Optical Properties for a Statistically Complete Sample of Poor Galaxy Clusters

From the poor cluster catalog of White et al. (1996), we define a sample of 71 optically-selected poor galaxy clusters. The surface-density enhance- ment we require for our clusters falls between that of the loose associations of Turner and Gott (1976) and the Hickson compact groups (Hickson, 1982). We review the selection biases and determine the statistical comleteness of the sample. For this sample, we report new velocity measurements made with the ARC 3.5-m Dual-Imaging spectrograph and the 2.3-m Steward Observatory MX fiber spectrograph. Combining our own measurements with those from the literature, we examine the velocity distributions, velocity dispersions, and 1-d velocity substructure for our poor cluster sample, and compare our results to other poor cluster samples. We find that approximately half of the sample may have significant 1-d velocity substructure. The optical morphology, large-scale environment, and velocity field of many of these clusters is indicative of young, dynamically evolving systems. In future papers, we will use this sample to derive the poor cluster X-ray luminosity function and gas mass function (see astro-ph/9606120), and will examine the optical/X-ray properties of the clusters in more detail.Comment: 15 pages LaTeX, 3 tables, 5 postscript figures. To appear in the August 1996 Astronomical Journa

Formation of Cool Cores in Galaxy Clusters via Hierarchical Mergers

We present a new scenario for the formation of cool cores in rich galaxy clusters based on results from recent high spatial dynamic range, adaptive mesh Eulerian hydrodynamic simulations of large-scale structure formation. We find that cores of cool gas, material that would be identified as a classical cooling flow based on its X-ray luminosity excess and temperature profile, are built from the accretion of discrete, stable subclusters. Any ``cooling flow'' present is overwhelmed by the velocity field within the cluster - the bulk flow of gas through the cluster typically has speeds up to about 2,000 km s^-1 and significant rotation is frequently present in the cluster core. The inclusion of consistent initial cosmological conditions for the cluster within its surrounding supercluster environment is crucial when simulating the evolution of cool cores in rich galaxy clusters. This new model for the hierarchical assembly of cool gas naturally explains the high frequency of cool cores in rich galaxy clusters despite the fact that a majority of these clusters show evidence of substructure which is believed to arise from recent merger activity. Furthermore, our simulations generate complex cluster cores in concordance with recent X-ray observations of cool fronts, cool ``bullets'', and filaments in a number of galaxy clusters. Our simulations were computed with a coupled N-body, Eulerian, adaptive mesh refinement, hydrodynamics cosmology code that properly treats the effects of shocks and radiative cooling by the gas. We employ up to seven levels of refinement to attain a peak resolution of 15.6 h^-1 kpc within a volume 256 h-1 Mpc on a side and assume a standard LambdaCDM cosmology.Comment: To appear in ApJ, 41 pages, 20 Figures and 2 Tables. Full resolution figures are available at http://casa.colorado.edu/~motl/astro-p

Optimised insert design for improved single-molecule imaging and quantification through CRISPR-Cas9 mediated knock-in

© 2019, The Author(s). The use of CRISPR-Cas9 genome editing to introduce endogenously expressed tags has the potential to address a number of the classical limitations of single molecule localisation microscopy. In this work we present the first systematic comparison of inserts introduced through CRISPR-knock in, with the aim of optimising this approach for single molecule imaging. We show that more highly monomeric and codon optimised variants of mEos result in improved expression at the TubA1B locus, despite the use of identical guides, homology templates, and selection strategies. We apply this approach to target the G protein-coupled receptor (GPCR) CXCR4 and show a further insert dependent effect on expression and protein function. Finally, we show that compared to over-expressed CXCR4, endogenously labelled samples allow for accurate single molecule quantification on ligand treatment. This suggests that despite the complications evident in CRISPR mediated labelling, the development of CRISPR-PALM has substantial quantitative benefits

Meeting Report from the Genomic Standards Consortium (GSC) Workshop 10

This report summarizes the proceedings of the 10th workshop of the Genomic Standards Consortium (GSC), held at Argonne National Laboratory, IL, USA. It was the second GSC workshop to have open registration and attracted over 60 participants who worked together to progress the full range of projects ongoing within the GSC. Overall, the primary focus of the workshop was on advancing the M5 platform for next-generation collaborative computational infrastructures. Other key outcomes included the formation of a GSC working group focused on MIGS/MIMS/MIENS compliance using the ISA software suite and the formal launch of the GSC Developer Working Group. Further information about the GSC and its range of activities can be found at http://gensc.org/

Non-renormalization theorems in softly broken SQED and the soft β\beta-functions

The renormalization of softly broken SQED is related to the one of supersymmetric QED by using the construction with a local gauge supercoupling and by taking into account softly broken anomalous axial U(1) symmetry. From this extended model one obtains the non-renormalization theorems of SQED and the counterterms of the soft breaking parameters as functions of the supersymmetric counterterms. Due to the Adler-Bardeen anomaly of the axial current an invariant regularization scheme does not exist, and therefore the $\beta$-functions of soft breaking parameters are derived from an algebraic construction of the Callan-Symanzik equation and of the renormalization group equation. We obtain the soft $\beta$-functions in terms of the gauge $\beta$-function and of the anomalous dimension of the supersymmetric matter mass. In particular, we find that the X-term of the scalar mass $\beta$-function as well as the gauge $\beta$-function in $l\geq 2$ are due to the Adler-Bardeen anomaly of the axial symmetry.Comment: 28 page