103 research outputs found
High Energy Neutrino Astronomy: Towards Kilometer-Scale Detectors
Of all high-energy particles, only neutrinos can directly convey astronomical
information from the edge of the universe---and from deep inside the most
cataclysmic high-energy processes. Copiously produced in high-energy
collisions, travelling at the velocity of light, and not deflected by magnetic
fields, neutrinos meet the basic requirements for astronomy. Their unique
advantage arises from a fundamental property: they are affected only by the
weakest of nature's forces (but for gravity) and are therefore essentially
unabsorbed as they travel cosmological distances between their origin and us.
Many of the outstanding mysteries of astrophysics may be hidden from our sight
at all wavelengths of the electromagnetic spectrum because of absorption by
matter and radiation between us and the source. For example, the hot dense
regions that form the central engines of stars and galaxies are opaque to
photons. In other cases, such as supernova remnants, gamma ray bursters, and
active galaxies, all of which may involve compact objects or black holes at
their cores, the precise origin of the high-energy photons emerging from their
surface regions is uncertain. Therefore, data obtained through a variety of
observational windows---and especially through direct observations with
neutrinos---may be of cardinal importance. In this talk, the scientific goals
of high energy neutrino astronomy and the technical aspects of water and ice
Cherenkov detectors are examined, and future experimental possibilities,
including a kilometer-square deep ice neutrino telescope, are explored.Comment: 13 pages, Latex, 6 postscript figures, uses aipproc.sty and epsf.sty.
Talk presented at the International Symposium on High Energy Gamma Ray
Astronomy, Heidelberg, June 200
Constructing Dirac linear fermions in terms of non-linear Heisenberg spinors
We show that the massive (or massless) neutrinos can be described as special
states of Heisenberg nonlinear spinors. As a by-product of this decomposition a
particularly attractive consequence appears: the possibility of relating the
existence of only three species of mass-less neutrinos to such internal
non-linear structure. At the same time it allows the possibility that neutrino
oscillation can occurs even for massless neutrinos
Dynamical Mean-Field Theory within an Augmented Plane-Wave Framework: Assessing Electronic Correlations in the Iron Pnictide LaFeAsO
We present an approach that combines the local density approximation (LDA)
and the dynamical mean-field theory (DMFT) in the framework of the
full-potential linear augmented plane waves (FLAPW) method. Wannier-like
functions for the correlated shell are constructed by projecting local orbitals
onto a set of Bloch eigenstates located within a certain energy window. The
screened Coulomb interaction and Hund's coupling are calculated from a
first-principle constrained RPA scheme. We apply this LDA+DMFT implementation,
in conjunction with continuous-time quantum Monte-Carlo, to study the
electronic correlations in LaFeAsO. Our findings support the physical picture
of a metal with intermediate correlations. The average value of the mass
renormalization of the Fe 3d bands is about 1.6, in reasonable agreement with
the picture inferred from photoemission experiments. The discrepancies between
different LDA+DMFT calculations (all technically correct) which have been
reported in the literature are shown to have two causes: i) the specific value
of the interaction parameters used in these calculations and ii) the degree of
localization of the Wannier orbitals chosen to represent the Fe 3d states, to
which many-body terms are applied. The latter is a fundamental issue in the
application of many-body calculations, such as DMFT, in a realistic setting. We
provide strong evidence that the DMFT approximation is more accurate and more
straightforward to implement when well-localized orbitals are constructed from
a large energy window encompassing Fe-3d, As-4p and O-2p, and point out several
difficulties associated with the use of extended Wannier functions associated
with the low-energy iron bands. Some of these issues have important physical
consequences, regarding in particular the sensitivity to the Hund's coupling.Comment: 16 pages, 9 figures, published versio
Flavor conversion of cosmic neutrinos from hidden jets
High energy cosmic neutrino fluxes can be produced inside relativistic jets
under the envelopes of collapsing stars. In the energy range E ~ (0.3 - 1e5)
GeV, flavor conversion of these neutrinos is modified by various matter effects
inside the star and the Earth. We present a comprehensive (both analytic and
numerical) description of the flavor conversion of these neutrinos which
includes: (i) oscillations inside jets, (ii) flavor-to-mass state transitions
in an envelope, (iii) loss of coherence on the way to observer, and (iv)
oscillations of the mass states inside the Earth. We show that conversion has
several new features which are not realized in other objects, in particular
interference effects ("L- and H- wiggles") induced by the adiabaticity
violation. The neutrino-neutrino scattering inside jet and inelastic neutrino
interactions in the envelope may produce some additional features at E > 1e4
GeV. We study dependence of the probabilities and flavor ratios in the
matter-affected region on angles theta13 and theta23, on the CP-phase delta, as
well as on the initial flavor content and density profile of the star. We show
that measurements of the energy dependence of the flavor ratios will, in
principle, allow to determine independently the neutrino and astrophysical
parameters.Comment: 56 pages, 19 figures. Minor changes. Accepted by JHEP
Bioinformatics in crosslinking chemistry of collagen with selective cross linkers
<p>Abstract</p> <p>Background</p> <p>Identifying the molecular interactions using bioinformatics tools before venturing into wet lab studies saves the energy and time considerably. The present study summarizes, molecular interactions and binding energy calculations made for major structural protein, collagen of Type I and Type III with the chosen cross-linkers, namely, coenzyme Q<sub>10</sub>, dopaquinone, embelin, embelin complex-1 & 2, idebenone, 5-O-methyl embelin, potassium embelate and vilangin.</p> <p>Results</p> <p>Molecular descriptive analyses suggest, dopaquinone, embelin, idebenone, 5-O-methyl embelin, and potassium embelate display nil violations. And results of docking analyses revealed, best affinity for Type I (- 4.74 kcal/mol) and type III (-4.94 kcal/mol) collagen was with dopaquinone.</p> <p>Conclusions</p> <p>Among the selected cross-linkers, dopaquinone, embelin, potassium embelate and 5-O-methyl embelin were the suitable cross-linkers for both Type I and Type III collagen and stabilizes the collagen at the expected level.</p
Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress
Cytogerontology, the science of cellular ageing, originated in 1881 with the prediction by August Weismann that the somatic cells of higher animals have limited division potential. Weismann's prediction was derived by considering the role of natural selection in regulating the duration of an organism's life. For various reasons, Weismann's ideas on ageing fell into neglect following his death in 1914, and cytogerontology has only reappeared as a major research area following the demonstration by Hayflick and Moorhead in the early 1960s that diploid human fibroblasts are restricted to a finite number of divisions in vitro.
In this review we give a detailed account of Weismann's theory, and we reveal that his ideas were both more extensive in their scope and more pertinent to current research than is generally recognised. We also appraise the progress which has been made over the past hundred years in investigating the causes of ageing, with particular emphasis being given to (i) the evolution of ageing, and (ii) ageing at the cellular level. We critically assess the current state of knowledge in these areas and recommend a series of points as primary targets for future research
A Comparison of Stress Levels, Coping Styles and Psychological Morbidity Between Graduate-entry and Traditional Undergraduate Medical Students During the First 2 Years at a UK Medical School.
Background:
Stress levels and psychological morbidity are high among undergraduate medical students (UGs), but there is a lack of research into the psychological health of UK graduate-entry medical students (GEs). GEs are likely to experience different (perhaps more severe) stressors and to cope with stress differently. We compared stress levels, psychological morbidity and coping styles in GE versus UG medical students studying at the same UK medical school in the same academic year.
Method:
A cross-sectional self-rated questionnaire study of all first- and second-year GE and UG medical students. Perceived stress, psychological morbidity, recent adverse life events, stress-related personality traits and coping styles were assessed using standard questionnaires.
Results:
75% GEs and 46% UGs responded to the questionnaire. Both groups reported equally high levels, and similar profiles of, perceived stress and psychological morbidity. Levels of recent adverse life events and stress-related personality traits were similar in both groups. Compared to UGs, GEs were more likely to use active coping (p = 0.02) and positive reframing (p = 0.03), but were also more likely to use substances (alcohol and other drugs; p < 0.001) to help them cope. Unlike UGs, second-year GEs showed less perceived stress (p = 0.007) and psychological morbidity (p = 0.006) than first-year GEs although levels of both were still high.
Conclusion:
Our results show that both GE students and their younger UG counterparts on a traditional medical course have similar profiles of stress symptoms. They do, however, cope with stress differently. GEs are more likely to use active problem-focused coping strategies, and they are also more likely to cope by using substances (alcohol or other drugs). GE students need interventions to prevent maladaptive coping styles and encourage adaptive coping that are tailored to their needs. Such interventions should be targeted at first-year students. It is vital that these students develop positive coping skills to benefit them during training and in a future career that is inherently stressful
Psychological quality of life and its association with academic employability skills among newly-registered students from three European faculties
In accord with new European university reforms initiated by the Bologna Process, our objectives were to assess psychological quality of life (QoL) and to analyse its associations with academic employability skills (AES) among students from the Faculty of Language, Literature, Humanities, Arts and Education, Walferdange Luxembourg (F1, mostly vocational/applied courses); the Faculty of Social and Human Sciences, Liege, Belgium (F2, mainly general courses); and the Faculty of Social Work, Iasi, Romania (F3, mainly vocational/professional courses). Method: Students who redoubled or who had studied at other universities were excluded. 355 newly-registered first-year students (145 from F1, 125 from F2, and 85 from F3) were invited to complete an online questionnaire (in French, German, English or Romanian) covering socioeconomic data, the AES scale and the QoL-psychological, QoL-social relationships and QoL-environment subscales as measured with the World Health Organisation Quality of Life short-form (WHOQoL-BREF) questionnaire. Analyses included multiple regressions with interactions. Results: QoL-psychological, QoL-social relationships and QoL-environment’ scores were highest in F1 (Luxembourg), and the QoL-psychological score in F2 (Belgium) was the lower. AES score was higher in F1 than in F3 (Romania). A positive link was found between QoL-psychological and AES for F1 (correlation coefficient 0.29, p < 0.01) and F3 (correlation coefficient 0.30, p < 0.05), but the association was negative for F2 (correlation coefficient -0.25, p < 0.01). QoL-psychological correlated positively with QoL-social relationships (regression coefficient 0.31, p < 0.001) and QoL-environment (regression coefficient 0.35, p < 0.001). Conclusions: Psychological quality of life is associated with acquisition of skills that increase employability from the faculties offering vocational/applied/professional courses in Luxembourg and Romania, but not their academically orientated Belgian counterparts. In the context of developing a European Higher Educational Area, these measurements are major indicators that can be used as a guide to promoting programs geared towards counseling, improvement of the social environment, and services to assist with university work and facilitate achievement of future professional projects. Keywords: students WHOQoL-BREF, QoL-psychological, employability, academic skills, QoL-environmental, QoLsocial relationship
Egocentric and allocentric representations in auditory cortex
A key function of the brain is to provide a stable representation of an object’s location in the world. In hearing, sound azimuth and elevation are encoded by neurons throughout the auditory system, and auditory cortex is necessary for sound localization. However, the coordinate frame in which neurons represent sound space remains undefined: classical spatial receptive fields in head-fixed subjects can be explained either by sensitivity to sound source location relative to the head (egocentric) or relative to the world (allocentric encoding). This coordinate frame ambiguity can be resolved by studying freely moving subjects; here we recorded spatial receptive fields in the auditory cortex of freely moving ferrets. We found that most spatially tuned neurons represented sound source location relative to the head across changes in head position and direction. In addition, we also recorded a small number of neurons in which sound location was represented in a world-centered coordinate frame. We used measurements of spatial tuning across changes in head position and direction to explore the influence of sound source distance and speed of head movement on auditory cortical activity and spatial tuning. Modulation depth of spatial tuning increased with distance for egocentric but not allocentric units, whereas, for both populations, modulation was stronger at faster movement speeds. Our findings suggest that early auditory cortex primarily represents sound source location relative to ourselves but that a minority of cells can represent sound location in the world independent of our own position
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