2,491 research outputs found
BPS black holes, the Hesse potential, and the topological string
The Hesse potential is constructed for a class of four-dimensional N=2
supersymmetric effective actions with S- and T-duality by performing the
relevant Legendre transform by iteration. It is a function of fields that
transform under duality according to an arithmetic subgroup of the classical
dualities reflecting the monodromies of the underlying string compactification.
These transformations are not subject to corrections, unlike the
transformations of the fields that appear in the effective action which are
affected by the presence of higher-derivative couplings. The class of actions
that are considered includes those of the FHSV and the STU model. We also
consider heterotic N=4 supersymmetric compactifications. The Hesse potential,
which is equal to the free energy function for BPS black holes, is manifestly
duality invariant. Generically it can be expanded in terms of powers of the
modulus that represents the inverse topological string coupling constant,
, and its complex conjugate. The terms depending holomorphically on
are expected to correspond to the topological string partition function and
this expectation is explicitly verified in two cases. Terms proportional to
mixed powers of and are in principle present.Comment: 28 pages, LaTeX, added comment
A bioassay system of autologous human endothelial, smooth muscle cells and leucocytes for use in drug discovery, phenotyping and tissue engineering
Purpose: Blood vessels are comprised of endothelial and smooth muscle cells. Obtaining both types of cells from vessels of living donors is not possible without invasive surgery. To address this we have devised a strategy whereby human endothelial and smooth muscle cells derived from blood progenitors from the same donor could be cultured with autologous leucocytes to generate a same donor ‘vessel in a dish’ bioassay. Basic procedures: Autologous sets of blood outgrowth endothelial cells (BOECs), smooth muscle cells (BO-SMCs) and leucocytes were obtained from 4 donors. Cells were treated in mono and cumulative co-culture conditions. The endothelial specific mediator endothelin-1 along with interleukin (IL)-6, IL-8, tumour necrosis factor α, and interferon gamma-induced protein 10 were measured under control culture conditions and after stimulation with cytokines. Main findings: Co-cultures remained viable throughout. The profile of individual mediators released from cells was consistent with what we know of endothelial and smooth muscle cells cultured from blood vessels. Principle conclusions: For the first time, we report a proof of concept study where autologous blood outgrowth ‘vascular’ cells and leucocytes were studied alone and in co-culture. This novel bioassay has utility in vascular biology research, patient phenotyping, drug testing and tissue engineering
Counting all dyons in N =4 string theory
For dyons in heterotic string theory compactified on a six-torus, with
electric charge vector Q and magnetic charge vector P, the positive integer I =
g.c.d.(Q \wedge P) is an invariant of the U-duality group. We propose the
microscopic theory for computing the spectrum of all dyons for all values of I,
generalizing earlier results that exist only for the simplest case of I=1. Our
derivation uses a combination of arguments from duality, 4d-5d lift, and a
careful analysis of fermionic zero modes. The resulting degeneracy agrees with
the black hole degeneracy for large charges and with the degeneracy of
field-theory dyons for small charges. It naturally satisfies several physical
requirements including integrality and duality invariance. As a byproduct, we
also derive the microscopic (0,4) superconformal field theory relevant for
computing the spectrum of five-dimensional Strominger-Vafa black holes in ALE
backgrounds and count the resulting degeneracies
Enhanced error estimator based on a nearly equilibrated moving least squares recovery technique for FEM and XFEM
In this paper a new technique aimed to obtain accurate estimates of the error
in energy norm using a moving least squares (MLS) recovery-based procedure is
presented. We explore the capabilities of a recovery technique based on an
enhanced MLS fitting, which directly provides continuous interpolated fields,
to obtain estimates of the error in energy norm as an alternative to the
superconvergent patch recovery (SPR). Boundary equilibrium is enforced using a
nearest point approach that modifies the MLS functional. Lagrange multipliers
are used to impose a nearly exact satisfaction of the internal equilibrium
equation. The numerical results show the high accuracy of the proposed error
estimator
Development of a novel UPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping
Amine quantification is an important strategy in patient stratification and personalised medicine. This is because amines, including amino acids and methylarginines impact on many homeostatic processes. One important pathway regulated by amine levels is nitric oxide synthase (NOS). NOS is regulated by levels of (i) the substrate, arginine, (ii) amino acids which cycle with arginine and (iii) methylarginine inhibitors of NOS. However, biomarker research in this area is hindered by the lack of a unified analytical platform. Thus, the development of a common metabolomics platform, where a wide range of amino acids and methylarginines can be measured constitutes an important unmet need. Here we report a novel high-throughput ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) platform where ≈40 amine analytes, including arginine and methylarginines can be detected and quantified on a molar basis, in a single sample of human plasma. To validate the platform and to generate biomarkers, human plasma from a well-defined cohort of patients before and after coronary artery bypass surgery, who developed systemic inflammatory response syndrome (SIRS), were analysed. Bypass surgery with SIRS significantly altered 26 amine analytes, including arginine and ADMA. Consequently, pathway analysis revealed significant changes in a range of pathways including those associated with NOS
Condensate cosmology in O'Raifeartaigh models
Flat directions charged under an R-symmetry are a generic feature of
O'Raifeartaigh models. Non-topological solitons associated with this symmetry,
R-balls, are likely to form through the fragmentation of a condensate, itself
created by soft terms induced during inflation. In gravity mediated SUSY
breaking R-balls decay to gravitinos, reheating the universe. For gauge
mediation R-balls can provide a good dark matter candidate. Alternatively they
can decay, either reheating or cooling the universe. Conserved R-symmetry
permits decay to gravitinos or gauginos, whereas spontaneously broken
R-symmetry results in decay to visible sector gauge bosons.Comment: 29 pages, 5 figures. Comments and references added, accepted for
publication in JHE
Long-Lived Neutralino NLSPs
We investigate the collider signatures of heavy, long-lived, neutral
particles that decay to charged particles plus missing energy. Specifically, we
focus on the case of a neutralino NLSP decaying to Z and gravitino within the
context of General Gauge Mediation. We show that a combination of searches
using the inner detector and the muon spectrometer yields a wide range of
potential early LHC discoveries for NLSP lifetimes ranging from 10^(-1)-10^5
mm. We further show that events from Z(l+l-) can be used for detailed kinematic
reconstruction, leading to accurate determinations of the neutralino mass and
lifetime. In particular, we examine the prospects for detailed event study at
ATLAS using the ECAL (making use of its timing and pointing capabilities)
together with the TRT, or using the muon spectrometer alone. Finally, we also
demonstrate that there is a region in parameter space where the Tevatron could
potentially discover new physics in the delayed Z(l+l-)+MET channel. While our
discussion centers on gauge mediation, many of the results apply to any
scenario with a long-lived neutral particle decaying to charged particles.Comment: 31 pages, 12 figure
General Gauge Mediation at the Weak Scale
We completely characterize General Gauge Mediation (GGM) at the weak scale by
solving all IR constraints over the full parameter space. This is made possible
through a combination of numerical and analytical methods, based on a set of
algebraic relations among the IR soft masses derived from the GGM boundary
conditions in the UV. We show how tensions between just a few constraints
determine the boundaries of the parameter space: electroweak symmetry breaking
(EWSB), the Higgs mass, slepton tachyons, and left-handed stop/sbottom
tachyons. While these constraints allow the left-handed squarks to be
arbitrarily light, they place strong lower bounds on all of the right-handed
squarks. Meanwhile, light EW superpartners are generic throughout much of the
parameter space. This is especially the case at lower messenger scales, where a
positive threshold correction to coming from light Higgsinos and winos is
essential in order to satisfy the Higgs mass constraint.Comment: 43 pages, 20 figures, mathematica package included in the sourc
Prompt Decays of General Neutralino NLSPs at the Tevatron
Recent theoretical developments have shown that gauge mediation has a much
larger parameter space of possible spectra and mixings than previously
considered. Motivated by this, we explore the collider phenomenology of gauge
mediation models where a general neutralino is the lightest MSSM superpartner
(the NLSP), focusing on the potential reach from existing and future Tevatron
searches. Promptly decaying general neutralino NLSPs can give rise to final
states involving missing energy plus photons, Zs, Ws and/or Higgses. We survey
the final states and determine those where the Tevatron should have the most
sensitivity. We then estimate the reach of existing Tevatron searches in these
final states and discuss new searches (or optimizations of existing ones) that
should improve the reach. Finally we comment on the potential for discovery at
the LHC.Comment: 41 pages, minor changes, added refs and discussion of previous
literatur
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