610 research outputs found
PCV1 Costo-Efectividad De Un Programa De Nefroproteccion En Una Cohorte De 17.000 Pacientes Con Enfermedad Renal Cronica Afiliados A Una Aseguradora En Salud En Colombia
PHS54 Cost-Effectiveness Of A Care Program For Hiv/Aids Patients Insured By A Health Maintenance Organization In Colombia Comparing Three Health Care Providers Nationwide
PHS41 Direct costs of Health care for Breast Cancer, the case of a Health manteinance Organization in Colombia
Comparing "challenge-based" and "code-based" internet voting verification implementations
Internet-enabled voting introduces an element of invisibility and unfamiliarity into the voting process, which makes it very different from traditional voting. Voters might be concerned about their vote being recorded correctly and included in the final tally. To mitigate mistrust, many Internet-enabled voting systems build verifiability into their systems. This allows voters to verify that their votes have been cast as intended, stored as cast and tallied as stored at the conclusion of the voting period. Verification implementations have not been universally successful, mostly due to voter difficulties using them. Here, we evaluate two cast as intended verification approaches in a lab study: (1) "Challenge-Based" and (2) "Code-Based". We assessed cast-as-intended vote verification efficacy, and identified usability issues related to verifying and/or vote casting. We also explored acceptance issues post-verification, to see whether our participants were willing to engage with Internet voting in a real election. Our study revealed the superiority of the code-based approach, in terms of ability to verify effectively. In terms of real-life Internet voting acceptance, convenience encourages acceptance, while security concerns and complexity might lead to rejection
Community Member Perspectives from Transgender Women and Men Who Have Sex with Men on Pre-Exposure Prophylaxis as an HIV Prevention Strategy: Implications for Implementation
Background: An international randomized clinical trial (RCT) on pre-exposure prophylaxis (PrEP) as an human immunodeficiency virus (HIV)-prevention intervention found that taken on a daily basis, PrEP was safe and effective among men who have sex with men (MSM) and male-to-female transgender women. Within the context of the HIV epidemic in the United States (US), MSM and transgender women are the most appropriate groups to target for PrEP implementation at the population level; however, their perspectives on evidenced-based biomedical research and the results of this large trial remain virtually unknown. In this study, we examined the acceptability of individual daily use of PrEP and assessed potential barriers to community uptake. Methods: We conducted semi-structured interviews with an ethnoracially diverse sample of thirty HIV-negative and unknown status MSM (n = 24) and transgender women (n = 6) in three California metropolitan areas. Given the burden of disease among ethnoracial minorities in the US, we purposefully oversampled for these groups. Thematic coding and analysis of data was conducted utilizing an approach rooted in grounded theory. Results: While participants expressed general interest in PrEP availability, results demonstrate: a lack of community awareness and confusion about PrEP; reservations about PrEP utilization, even when informed of efficacious RCT results; and concerns regarding equity and the manner in which a PrEP intervention could be packaged and marketed in their communities. Conclusions: In order to effectively reduce HIV health disparities at the population level, PrEP implementation must take into account the uptake concerns of those groups who would actually access and use this biomedical intervention as a prevention strategy. Recommendations addressing these concerns are provided
Human-centered Explainable AI: Towards a Reflective Sociotechnical Approach
Explanations--a form of post-hoc interpretability--play an instrumental role
in making systems accessible as AI continues to proliferate complex and
sensitive sociotechnical systems. In this paper, we introduce Human-centered
Explainable AI (HCXAI) as an approach that puts the human at the center of
technology design. It develops a holistic understanding of "who" the human is
by considering the interplay of values, interpersonal dynamics, and the
socially situated nature of AI systems. In particular, we advocate for a
reflective sociotechnical approach. We illustrate HCXAI through a case study of
an explanation system for non-technical end-users that shows how technical
advancements and the understanding of human factors co-evolve. Building on the
case study, we lay out open research questions pertaining to further refining
our understanding of "who" the human is and extending beyond 1-to-1
human-computer interactions. Finally, we propose that a reflective HCXAI
paradigm-mediated through the perspective of Critical Technical Practice and
supplemented with strategies from HCI, such as value-sensitive design and
participatory design--not only helps us understand our intellectual blind
spots, but it can also open up new design and research spaces.Comment: In Proceedings of HCI International 2020: 22nd International
Conference On Human-Computer Interactio
Identification of a large, fast-expanding HIV-1 subtype B transmission cluster among MSM in Valencia, Spain
We describe and characterize an exceptionally large HIV-1 subtype B transmission cluster occurring in the Comunidad Valenciana (CV, Spain). A total of 1806 HIV-1 protease-reverse transcriptase (PR/RT) sequences from different patients were obtained in the CV between 2004 and 2014. After subtyping and generating a phylogenetic tree with additional HIV-1 subtype B sequences, a very large transmission cluster which included almost exclusively sequences from the CV was detected (n = 143 patients). This cluster was then validated and characterized with further maximum-likelihood phylogenetic analyses and Bayesian coalescent reconstructions. With these analyses, the CV cluster was delimited to 113 patients, predominately men who have sex with men (MSM). Although it was significantly located in the city of Valencia (n = 105), phylogenetic analyses suggested this cluster derives from a larger HIV lineage affecting other Spanish localities (n = 194). Coalescent analyses estimated its expansion in Valencia to have started between 1998 and 2004. From 2004 to 2009, members of this cluster represented only 1.46% of the HIV-1 subtype B samples studied in Valencia (n = 5/143), whereas from 2010 onwards its prevalence raised to 12.64% (n = 100/791). In conclusion, we have detected a very large transmission cluster in the CV where it has experienced a very fast growth in the recent years in the city of Valencia, thus contributing significantly to the HIV epidemic in this locality. Its transmission efficiency evidences shortcomings in HIV control measures in Spain and particularly in Valencia
The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters
HIV infections are still a very serious concern for public heath worldwide. We have applied molecular evolution methods to study the HIV-1 epidemics in the Comunidad Valenciana (CV, Spain) from a public health surveillance perspective. For this, we analysed 1804 HIV-1 sequences comprising protease and reverse transcriptase (PR/RT) coding regions, sampled between 2004 and 2014. These sequences were subtyped and subjected to phylogenetic analyses in order to detect transmission clusters. In addition, univariate and multinomial comparisons were performed to detect epidemiological differences between HIV-1 subtypes, and risk groups. The HIV epidemic in the CV is dominated by subtype B infections among local men who have sex with men (MSM). 270 transmission clusters were identified (>57% of the dataset), 12 of which included â„10 patients; 11 of subtype B (9 affecting MSMs) and one (n = 21) of CRF14, affecting predominately intravenous drug users (IDUs). Dated phylogenies revealed these large clusters to have originated from the mid-80s to the early 00 s. Subtype B is more likely to form transmission clusters than non-B variants and MSMs to cluster than other risk groups. Multinomial analyses revealed an association between non-B variants, which are not established in the local population yet, and different foreign groups
Switching from tipranavir (TPV) 500/ritonavir (RTV) 200 mg to TPV 500/RTV 100 mg in treatment-experienced patients (pts) with HIV RNA <50 copies/mL
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