4,486 research outputs found

    Nine Principles of Semantic Harmonization

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    Medical data is routinely collected, stored and recorded across different institutions and in a range of different formats. Semantic harmonization is the process of collating this data into a singular consistent logical view, with many approaches to harmonizing both possible and valid. The broad scope of possibilities for undertaking semantic harmonization do lead however to the development of bespoke and ad-hoc systems; this is particularly the case when it comes to cohort data, the format of which is often specific to a cohort's area of focus. Guided by work we have undertaken in developing the 'EMIF Knowledge Object Library', a semantic harmonization framework underpinning the collation of pan-European Alzheimer's cohort data, we have developed a set of nine generic guiding principles for developing semantic harmonization frameworks, the application of which will establish a solid base for constructing similar frameworks

    NGC 5775: Anatomy of a disk-halo interface

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    We present the first high-resolution study of the disk-halo interface in an edge-on galaxy (NGC 5775) in which every component of the interstellar medium is represented and resolved (though not all to the same resolution). New single-dish CO J=2-1 and CO J=1-0 data, ROSAT X-ray data, and HIRES IRAS data are presented along with HI data which emphasizes the high latitude features. In conjunction with previously published radio continuum (6 and 20 cm) and H data, we find spatial correlations between various ISM components in that all components of the ISM are present in the disk-halo features (except for CO for which there is insufficient spatial coverage). The HI features extend to ~7 kpc above the plane, form loops in position-position space, in one case, form a loop in position-velocity space, and are also observed over a large velocity range. This implies that the disk-halo features represent expanding supershells. However, the shells may be incomplete and partially open-topped, suggesting that we are observing the breakup of the supershells as they traverse the disk-halo interface. There is some evidence for acceleration with z and both redshifted and blueshifted velocities are present, although the gas which is lagging with respect to galactic rotation dominates. The radio continuum spectral index is flatter around the shell rims and we show that this cannot be due to a contribution from thermal gas but rather is due to intrinsic flattening of the non-thermal spectral index, suggesting that shocks may be important in these regions. The H emission is located interior to the HI. For feature F3, the H emission forms the interior skin of the HI shell, yet there appears to be a minimum of in-disk star formation immediately below the feature. We present a picture of a typical HI supershell which accelerates and breaks up through the disk-halo interface. Such a feature is likely internally generated via an energetic event in the disk

    The perceptions of undertaking a higher degree alongside orthodontic speciality training: a cross-sectional survey of British Orthodontic Society members

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    Introduction: In the UK, orthodontic speciality training takes place over three years full-time. In addition to the clinical training, there is an expectation that trainees undertake a higher degree. Currently, there is little evidence regarding the impact of undertaking a higher degree on specialist orthodontists. Aims: Investigate UK orthodontists' perceptions of undertaking a higher degree alongside speciality training. Materials and methods: A cross-sectional research study involving the distribution of an anonymous, descriptive, online, questionnaire-based survey between May and June 2021 via the British Orthodontic Society. Data were obtained in relation to the impact of undertaking a higher degree on the completion of speciality training, research skills, delivery of patient care and career opportunities. Results: In total, 166 questionnaires were completed (approximately 13.3% response rate). Most respondents 'agreed' or 'strongly agreed' that undertaking a higher degree had improved their scientific (77.1%) and critical appraisal skills (80.7%), job prospects (60.2%) and career opportunities (63.9%). Most respondents felt the benefits of the higher degree outweighed the associated costs (65.1%) and was a worthwhile component of training (69.3%). Conclusions: Specialist orthodontists place a high value on undertaking a higher degree. The results of this questionnaire should be of importance to stakeholders involved in the development of the orthodontic curriculum

    Traditional, virtual, and digital intermediaries in university-industry collaboration: exploring institutional logics and bounded rationality

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    This is the final version. Available on open access from Elsevier via the DOI in this recordUniversity-industry collaboration now extends beyond traditional intermediary structures and logics, enabled by more contemporary virtual networks and digital formats. This however poses new strategic and operational challenges for effective and responsive knowledge transfer. The purpose of this paper is to compare traditional models of knowledge transfer intermediaries in university-industry collaboration with emerging, virtual (network-based) and digital intermediaries by exploring their structures (thus institutional logics) and their services (their agency). We synthesise literature to form a comprehensive analytical framework to assess the structure and agency of twenty international knowledge transfer intermediaries from around the world. Further running a cluster analysis using multiple correspondence analysis method and following its results we propose a unique combination of institutional logic and bounded rationality lenses, which allowed us to identify four types of knowledge transfer intermediaries: rigid, rigid-unbounded, agent-bounded and agile. Our unique framework contributes to existing knowledge focused on traditional forms of knowledge transfer intermediaries, by identifying and positing institutional logics for emerging contemporary virtual and digital intermediaries in university-industry collaboration.Finnish Foundation for Economic Education (Liikesivistysrahasto)Scandinavian Consortium for Organizational Research (SCANCOR

    A Time Series Analysis of Air Pollution and Preterm Birth in Pennsylvania, 1997–2001

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    Preterm delivery can lead to serious infant health outcomes, including death and lifelong disability. Small increases in preterm delivery risk in relation to spatial gradients of air pollution have been reported, but previous studies may have controlled inadequately for individual factors. Using a time-series analysis, which eliminates potential confounding by individual risk factors that do not change over short periods of time, we investigated the effect of ambient outdoor particulate matter with diameter ≤10 μm (PM(10)) and sulfur dioxide on risk for preterm delivery. Daily counts of preterm births were obtained from birth records in four Pennsylvania counties from 1997 through 2001. We observed increased risk for preterm delivery with exposure to average PM(10) and SO(2) in the 6 weeks before birth [respectively, relative risk (RR) = 1.07; 95% confidence interval (CI), 0.98–1.18 per 50 μg/m(3) increase; RR = 1.15; 95% CI, 1.00–1. 32 per 15 ppb increase], adjusting for long-term preterm delivery trends, co-pollutants, and offsetting by the number of gestations at risk. We also examined lags up to 7 days before the birth and found an acute effect of exposure to PM(10) 2 days and 5 days before birth (respectively, RR = 1.10; 95% CI, 1.00–1.21; RR = 1.07; 95% CI, 0.98–1.18) and SO(2) 3 days before birth (RR = 1.07; 95% CI, 0.99–1.15), adjusting for covariates, including temperature, dew point temperature, and day of the week. The results from this time-series analysis, which provides evidence of an increase in preterm birth risk with exposure to PM(10) and SO(2), are consistent with prior investigations of spatial contrasts

    Scientists’ Warning on Climate Change and Medicinal Plants

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    The recent publication of a World Scientists’ Warning to Humanity highlighted the fact that climate change, absent strenuous mitigation or adaptation efforts, will have profound negative effects for humanity and other species, affecting numerous aspects of life. In this paper, we call attention to one of these aspects, the effects of climate change on medicinal plants. These plants provide many benefits for human health, particularly in communities where Western medicine is unavailable. As for other species, their populations may be threatened by changing temperature and precipitation regimes, disruption of commensal relationships, and increases in pests and pathogens, combined with anthropogenic habitat fragmentation that impedes migration. Additionally, medicinal species are often harvested unsustainably, and this combination of pressures may push many populations to extinction. A second issue is that some species may respond to increased environmental stresses not only with declines in biomass production but with changes in chemical content, potentially affecting quality or even safety of medicinal products. We therefore recommend actions including conservation and local cultivation of valued plants, sustainability training for harvesters and certification of commercial material, preservation of traditional knowledge, and programs to monitor raw material quality, in addition to, of course, efforts to mitigate climate change

    Austerity, personalisation and the degradation of voluntary sector employment conditions

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    This qualitative study of two social care organisations, explores how public sector austerity and policies to personalise social care services through introducing individual budgets in the UK combine to reshape employment conditions. It further explores how these new market relations impact on staff morale and commitment. The individual case summaries reveal a remarkable degree of similarity in terms of employment outcomes, with social care workers experiencing an erosion of the standard employment relationship. Workers experience greater insecurity in areas of pay and conditions, working time, training and development, career prospects, along with work intensification. Worker morale appeared vulnerable as employees struggled to cope with worsening working conditions, but also expressed concerns with quality of care in an era of austerity
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