PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

BACKGROUND: PG545 is a heparan sulfate (HS) mimetic that inhibits tumour angiogenesis by sequestering angiogenic growth factors in the extracellular matrix (ECM), thus limiting subsequent binding to receptors. Importantly, PG545 also inhibits heparanase, the only endoglycosidase which cleaves HS chains in the ECM. The aim of the study was to assess PG545 in various solid tumour and metastasis models

Is There a Place for an Ageing Subject? Stories of Ageing at the University of the Third Age in Poland

The University of the Third Age (U3A) is an organization widely recognized for its achievements in the field of adult education. However, little research to date has addressed the position of the U3A in the context of the societal discourse on ageing. The aim of this study was to examine stories of ageing told by the U3A in Poland and to place these stories within the contemporary discourse of ageing. The study sought to reflect on the role of the U3A in providing an environment that encourages the growth of an ageing subject. The results of this study indicate that rather than resisting ageist discourses, the U3A simply rejects the idea of old age. The U3A characterizes its members as exceptional people who have nothing in common with old people outside of the U3A. Therefore, the U3A plays only a minor role in changing the social circumstances of old people in Poland

Becoming Old. The Gendered Body and the Experience of Aging

It seems rather obvious that the experience of ageing is not indifferent to gender, and that studies of gender ought to account for ageing and old age. Yet, the two subject matters have been rarely investigated together. This is due to the tendency to reduce ageing (as well as its gendered aspects) either to supposedly biological necessities or to their social construction and restrictions. Notwithstanding, both ageing and gender are first and foremost bodily phenomena. Aging, as well as gender are dimensions we experience, incorporate and express through our bodies. The aim of the proposed paper is to bridge the gap between the biological and social approaches to ageing and gender with a phenomenological-anthropological approach. In this respect, I want to argue that the biological and the social are intertwined in human embodiment. The paper thus addresses ageing and gender neither as purely biological nor as merely discursive phenomena, but as phenomena of an embodied experience. Experience in this sense is necessarily situated, constituted by biological, material, historical and socio-cultural circumstances. As situated bodily beings, we not only have a first, but also a second nature: social norms are incorporated in the ways we habitually relate to the world, ourselves and others. While the process of ageing always confronts us with the finitude and materiality of our bodily being in general, with respect to gender and ageing, this means, as situated, specific circumstances and norms influence not only the way we think about ageing, but also the processes of becoming older and the experience of our aged bodies. It seems rather obvious that the experience of ageing is not indifferent to gender, and that studies of gender ought to account for ageing and old age. Yet, the two subject matters have been rarely investigated together. This is due to the tendency to reduce ageing (as well as its gendered aspects) either to supposedly biological necessities or to their social construction and restrictions. Notwithstanding, both ageing and gender are first and foremost bodily phenomena. Aging, as well as gender are dimensions we experience, incorporate and express through our bodies. The aim of the proposed paper is to bridge the gap between the biological and social approaches to ageing and gender with a phenomenological-anthropological approach. In this respect, I want to argue that the biological and the social are intertwined in human embodiment. The paper thus addresses ageing and gender neither as purely biological nor as merely discursive phenomena, but as phenomena of an embodied experience. Experience in this sense is necessarily situated, constituted by biological, material, historical and socio-cultural circumstances. As situated bodily beings, we not only have a first, but also a second nature: social norms are incorporated in the ways we habitually relate to the world, ourselves and others. While the process of ageing always confronts us with the finitude and materiality of our bodily being in general, with respect to gender and ageing, this means, as situated, specific circumstances and norms influence not only the way we think about ageing, but also the processes of becoming older and the experience of our aged bodies. It seems rather obvious that the experience of ageing is not indifferent to gender, and that studies of gender ought to account for ageing and old age. Yet, the two subject matters have been rarely investigated together. This is due to the tendency to reduce ageing (as well as its gendered aspects) either to supposedly biological necessities or to their social construction and restrictions. Notwithstanding, both ageing and gender are first and foremost bodily phenomena. Aging, as well as gender are dimensions we experience, incorporate and express through our bodies. The aim of the proposed paper is to bridge the gap between the biological and social approaches to ageing and gender with a phenomenological-anthropological approach. In this respect, I want to argue that the biological and the social are intertwined in human embodiment. The paper thus addresses ageing and gender neither as purely biological nor as merely discursive phenomena, but as phenomena of an embodied experience. Experience in this sense is necessarily situated, constituted by biological, material, historical and socio-cultural circumstances. As situated bodily beings, we not only have a first, but also a second nature: social norms are incorporated in the ways we habitually relate to the world, ourselves and others. While the process of ageing always confronts us with the finitude and materiality of our bodily being in general, with respect to gender and ageing, this means, as situated, specific circumstances and norms influence not only the way we think about ageing, but also the processes of becoming older and the experience of our aged bodies. It seems rather obvious that the experience of ageing is not indifferent to gender, and that studies of gender ought to account for ageing and old age. Yet, the two subject matters have been rarely investigated together. This is due to the tendency to reduce ageing (as well as its gendered aspects) either to supposedly biological necessities or to their social construction and restrictions. Notwithstanding, both ageing and gender are first and foremost bodily phenomena. Aging, as well as gender are dimensions we experience, incorporate and express through our bodies. The aim of the proposed paper is to bridge the gap between the biological and social approaches to ageing and gender with a phenomenological-anthropological approach. In this respect, I want to argue that the biological and the social are intertwined in human embodiment. The paper thus addresses ageing and gender neither as purely biological nor as merely discursive phenomena, but as phenomena of an embodied experience. Experience in this sense is necessarily situated, constituted by biological, material, historical and socio-cultural circumstances. As situated bodily beings, we not only have a first, but also a second nature: social norms are incorporated in the ways we habitually relate to the world, ourselves and others. While the process of ageing always confronts us with the finitude and materiality of our bodily being in general, with respect to gender and ageing, this means, as situated, specific circumstances and norms influence not only the way we think about ageing, but also the processes of becoming older and the experience of our aged bodies. It seems rather obvious that the experience of ageing is not indifferent to gender, and that studies of gender ought to account for ageing and old age. Yet, the two subject matters have been rarely investigated together. This is due to the tendency to reduce ageing (as well as its gendered aspects) either to supposedly biological necessities or to their social construction and restrictions. Notwithstanding, both ageing and gender are first and foremost bodily phenomena. Aging, as well as gender are dimensions we experience, incorporate and express through our bodies. The aim of the proposed paper is to bridge the gap between the biological and social approaches to ageing and gender with a phenomenological-anthropological approach. In this respect, I want to argue that the biological and the social are intertwined in human embodiment. The paper thus addresses ageing and gender neither as purely biological nor as merely discursive phenomena, but as phenomena of an embodied experience. Experience in this sense is necessarily situated, constituted by biological, material, historical and socio-cultural circumstances. As situated bodily beings, we not only have a first, but also a second nature: social norms are incorporated in the ways we habitually relate to the world, ourselves and others. While the process of ageing always confronts us with the finitude and materiality of our bodily being in general, with respect to gender and ageing, this means, as situated, specific circumstances and norms influence not only the way we think about ageing, but also the processes of becoming older and the experience of our aged bodies