A nondiagrammatic calculation of the Rho parameter from heavy fermions

A simple nondiagrammatic evaluation of the nondecoupling effect of heavy fermions on the Veltman's Rho parameter is presented in detail. This calculation is based on the path integral approach, the electroweak chiral Lagrangian formalism, and the Schwinger proper time method.Comment: 11 page

Revisión sobre métodos de preparación, mecanismos y aplicaciones de péptidos antioxidantes en aceites

Natural antioxidants, especially those used in edible oil, are safer compared to chemically synthesized antioxidants. Therefore, research on natural antioxidants has become prevelant. Antioxidant peptides derived from food protein can effectively prevent oil oxidation. Protein hydrolyzation is widely applied for the production of antioxidant peptides in industry, and bioinformatics is employed nowadays to generate the desired peptide sequence. Furthermore, the mechanism of antioxidant peptides in the oil system is still controversial, which limits the further development of antioxidant peptides as food antioxidants. This review introduces the preparation method of antioxidant peptides and their mechanisms as well as applications in the oil. It will help to comprehensively understand the function of antioxidant peptides and promote their development in the oil field.Los antioxidantes naturales, especialmente utilizados en aceites comestibles, son más seguros en comparación con los antioxidantes sintetizados químicamente. Por lo tanto, la investigación sobre antioxidantes naturales se convierte en un punto de interés. Los péptidos antioxidantes derivados de las proteínas alimentarias pueden prevenir eficazmente la oxidación del aceite. La hidrolización de proteínas se usa ampliamente en la industria para la producción de péptidos antioxidantes y la bioinformática se emplea hoy en día para generar la secuencia de péptidos deseada. Además, el mecanismo de los péptidos antioxidantes en el sistema oleoso sigue siendo controvertido, lo que limita el desarrollo posterior de péptidos antioxidantes como antioxidantes alimentarios. Esta revisión presenta el método de preparación de péptidos antioxidantes y su mecanismo, así como las aplicaciones en aceite, lo que ayudará a comprender de manera integral la función de los péptidos antioxidantes y promoverá su desarrollo en el campo petrolero

Molecular cytogenetic aberrations in patients with multiple myeloma studied by interphase fluorescence in situ hybridization

Background: Multiple myeloma (MM) is an incurable hematological disorder characterized by the accumulation of malignant plasma cells within the bone marrow (BM). The clinical heterogeneity of MM is dictated by the cytogenetic aberrations present in the clonal plasma cells (PCs). Cytogenetic studies in MM are hampered by the hypoproliferative nature of plasma cells in MM. Therefore, fluorescence in situ hybridization (FISH) analysis combined with magnetic-activated cell sorting (MACS) is an attractive alternative for evaluation of numerical and structural chromosomal changes in MM. Methods: Interphase FISH studies with three different specific probes for the regions containing 13q14.3 (D13S319), 14q32 (IGHC/IGHV) and 1q12(CEP1 ) were performed in 48 MM patients. Interphase FISH studies with LSI IGH/CCND1, LSI IGH/FGFR3, and LSI IGH/MAF probes were used to detect t(11;14)(q13;q32), t(4;14)(p16;q32), and t(14;16)(q32;q23) in patients with 14q32 rearrangement. Results: Molecular cytogenetic aberrations were found in 40 (83.3%) of the 48 MM patients. 13 patients (27.1%) simultaneously had 13q deletion/monosomy 13 [del(13q14)], illegitimate IGH rearrangement and chromosome 1 abnormality. Del(13q14) was detected in 21 cases (43.7%), and illegitimate IGH rearrangements in 29 (60.4%) including 6 with t(11;14) and 5 with t(4;14). None of 9 patients with illegitimate IGH rearrangements and without t(11;14) or t(4;14) we detected had t(14;16) (q32;q23). 24 of the 48 MM patients (50%) had chromosome 1 abnormalities. Among 21 patients with del(13q14), 15 patients had Amp1q12;16 had IgH rearrangements. Whereas, among 27 cases without del(13q14), 8 had Amp1q12; 13 had IgH rearrangements. There was a strong association between del(13q14) and Amp1q12(c2 = 8.26, р < 0.01), and between del(13q14) and IgH rearrangement(c2 = 3.88, p < 0.05). Conclusion: 13q deletion/monosomy 13, IGH rearrangement and chromosome 1 abnormality are frequent in MM. They are not randomly distributed, but strongly interconnected. Interphase FISH technique combined with MACS using CD138-specific antibody is a highly sensitive technique at detecting molecular cytogenetic aberrations in MM.Обоснование: множественная миелома (MM) — неизлечимое гематологическое заболевание, характеризирующееся накоплением злокачественных плазматических клеток в костном мозге (КM). Клиническая гетерогенность MM определяется цитогенетическими аберрациями, присутствующими в клоне плазматических клеток (ПК). Цитогенетические исследования MM осложнены гипопролиферативными особенностями ПК. В связи с этим флуоресцентная гибридизация in situ (FISH) в комбинации с сортировкой клеток, активированных магнитными полями (MACS) представляется достойной альтернативой методам оценки точечных и структурных изменений хромосом при MM. Методы: интерфазные исследования методом FISH с использованием трех различных специфических зондов для участков, содержащих 13q14.3 (D13S319), 14q32 (IGHC/IGHV) и 1q12(CEP1), проводили у 48 больных с MM. Интерфазные исследования методом FISH с использованием зондов LSI IGH/CCND1, LSI IGH/FGFR3 и LSI IGH/MAF применяли для детекции t(11;14)(q13;q32), t(4;14)(p16;q32), и t(14;16)(q32;q23) у пациентов с перестройкой 14q32. Результаты: молекулярные цитогенетические аберрации выявляли у 40 (83,3%) из 48 больных с MM. У 13 пациентов (27,1%) одновременно определены 13q делеция/моносомия 13 [del(13q14)], аномальная перестройка IGH и аномалия хромосомы 1. Del(13q14) детектировали в 21 случае (43,7%), а аномальные перестройки IGH — в 29 (60,4%), в том числе у 6 пациентов с t(11;14) и 5 с t(4;14). Ни у одного из 9 больных с аномальными перестройками IGH и без t(11;14) или t(4;14) не выявляли транслокацию t(14;16) (q32;q23). У 24 из 48 пациентов с MM (50%) определяли аномалии хромосомы 1. В группе из 21 больных с del(13q14) в 15 случаях имелись перестройки IgH Amp1q12;16. В то же время из 27 случаев без del(13q14) у 8 содержались Amp1q12; в 13 случаях отмечали перестройки IgH. Выявлена взаимосвязь между del(13q14) и Amp1q12(χ2 = 8,26, p < 0,01) и между del(13q14) и перестройками IgH (χ2 = 3,88, p < 0,05). Выводы: 13q делецию/моносомию 13, перестройку IGH и аномалию хромосомы 1 часто отмечают при MM, причем их распределение не случайно и тесно взаимосвязано. Интерфазный анализ FISH в комбинации с MACS с использованием CD138-специфичных антител является высокочувствительным методом детекции молекулярных цитогенетических аберраций при MM

Non-Extremal D-instantons and the AdS/CFT Correspondence

We investigate non-extremal D-instantons in an asymptotically $AdS_5 \times S^5$ background and the role they play in the $AdS_5 / CFT_4$ correspondence. We find that the holographic dual operators of non-extremal D-instanton configurations do not correspond to self-dual Yang-Mills instantons, and we compute explicitly the deviation from self-duality. Furthermore, a class of non-extremal D-instantons yield Euclidean axionic wormhole solutions with two asymptotic boundaries. After Wick rotating, this provides a playground for investigating holography in the presence of cosmological singularities in a closed universe.Comment: 30 pages, 3 figure

Brane Cosmology in the Background of D-Brane with NS B Field

We study the cosmological evolution of the four-dimensional universe on the probe D3-brane in geodesic motion in the curved background of the source Dp-brane with non-zero NS B field. The Friedman equations describing the expansion of the brane universe are obtained and analyzed for various limits. We elaborate on corrections to the cosmological evolution due to nonzero NS B field.Comment: 13 pages, LaTeX, revised version with minor corrections to appear in Phys. Rev.

Oxygen radical-mediated oxidation reactions of an alanine peptide motif - density functional theory and transition state theory study

Background: Oxygen-base (O-base) oxidation in protein backbone is important in the protein backbone fragmentation due to the attack from reactive oxygen species (ROS). In this study, an alanine peptide was used model system to investigate this O-base oxidation by employing density functional theory (DFT) calculations combining with continuum solvent model. Detailed reaction steps were analyzed along with their reaction rate constants. Results: Most of the O-base oxidation reactions for this alanine peptide are exothermic except for the bond-breakage of the C-alpha-N bond to form hydroperoxy alanine radical. Among the reactions investigated in this study, the activated energy of OH alpha-H abstraction is the lowest one, while the generation of alkylperoxy peptide radical must overcome the highest energy barrier. The aqueous situation facilitates the oxidation reactions to generate hydroxyl alanine peptide derivatives except for the fragmentations of alkoxyl alanine peptide radical. The C-alpha-C-beta bond of the alkoxyl alanine peptide radical is more labile than the peptide bond. Conclusion: the rate-determining step of oxidation in protein backbone is the generation of hydroperoxy peptide radical via the reaction of alkylperoxy peptide radical with HO2. The stabilities of alkylperoxy peptide radical and complex of alkylperoxy peptide radical with HO2 are crucial in this O-base oxidation reaction

Assessing the association between dipeptidyl peptidase 4 inhibitor use and inflammatory bowel disease through drug adverse event reporting

Inflammatory bowel disease (IBD), including Crohn disease (CD) and ulcerative colitis (UC), is an autoimmune digestive system disease. A recent cohort study using the U.K. Clinical Practice Research Datalink (CPRD) involving 7,231 dipeptidyl peptidase 4 inhibitor (DPP4i) users with 49 IBD cases indicated that new use of DPP4is over a median duration of 1.6 years was associated with IBD risk in patients with type 2 diabetes compared with other noninsulin antihyperglycemic drugs (hazard ratio 1.75, 95% CI 1.22, 2.49). Current evidence regarding the effect of DPP4is on IBD risk is very limited. We thus performed a disproportionality analysis using the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database, which contains all adverse events spontaneously reported to the Food and Drug Administration since 2004

a.SCatch: semantic structure for architectural floor plan retrieval

Architects’ daily routine involves working with drawings. They use either a pen or a computer to sketch out their ideas or to do a drawing to scale. We therefore propose the use of a sketch-based approach when using the floor plan repository for queries. This enables the user of the system to sketch a schematic abstraction of a floor plan and search for floor plans that are structurally similar. We also propose the use of a visual query language, and a semantic structure as put forward by Langenhan. An algorithm extracts the semantic structure sketched by the architect on DFKI’s Touch& Write table and compares the structure of the sketch with that of those from the floor plan repository. The a.SCatch system enables the user to access knowledge from past projects easily. Based on CBR strategies and shape detection technologies, a sketch-based retrieval gives access to a semantic floor plan repository. Furthermore, details of a prototypical application which allows semantic structure to be extracted from image data and put into the repository semi-automatically are provided

Convergence of energy-dependent incommensurate antiferromagnetic neutron scattering peaks to commensurate resonance in underdoped bilayer cuprates

The recently discovered coexistence of incommensurate antiferromagnetic neutron scattering peaks and commensurate resonance in underdoped YBa$_2$Cu$_3$O$_{6+x}$ is calling for an explanation. Within the t-J model, the doping and energy dependence of the spin dynamics of the underdoped bilayer cuprates in the normal state is studied based on the fermion-spin theory by considering the bilayer interactions. Incommensurate peaks are found at $[(1\pm\delta)\pi,\pi]$ and $[\pi,(1\pm\delta)\pi]$ at low energies with $\delta$ initially increasing with doping at low dopings and then saturating at higher dopings. These incommensurate peaks are suppressed, and the parameter $\delta$ is reduced with increasing energy. Eventually it converges to the $[\pi,\pi]$ resonance peak. Thus the recently observed coexistence is interpreted in terms of bilayer interactions.Comment: 15 pages, Revtex, five figures are included, accepted for publication in Phys. Rev.

Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation

Although IGF-II activating the IGF-II receptor signaling pathway has been found to stimulate cardiomyocyte hypertrophy, the role of IGF-II in cardiac cell apoptosis remains unclear. This study aimed to identify the roles of IGF-II and/or IGF-II receptors (IGF-II/IIR) in cardiomyoblast apoptosis and in hypertensive rat hearts with abdominal aorta ligation. Cultured rat heart-derived H9c2 cardiomyoblasts and excised hearts from Sprague-Dawley rats with 0- to 20-day complete abdominal aorta ligation, a model of ANG II elevation and hypertension, were used. IGF-II/IIR expression, caspase activity, DNA fragmentation, and apoptotic cells were measured by RT-PCR, Western blot, agarose gel electrophoresis, and TUNEL assay following various combinations of ANG II, IGF-II/IIR antibody, CsA (calcineurin inhibitor), SP-600125 (JNK inhibitor), SB-203580 (p38 inhibitor), U-0126 (MEK inhibitor), or Staurosporine (PKC inhibitor) in H9c2 cells. ANG II-induced DNA fragmentation and TUNEL-positive cells were blocked by IGF-II/IIR antibodies and antisense IGF-II, but not by IGF-II sense. IGF-II-induced apoptosis was blocked by IGF-IIR antibody and CsA. The increased gene expressions of IGF-II and -IIR induced by ANG II were reversed by U-0126 and Sp600125, respectively. Caspase 8 activities induced by ANG II were attenuated by U-0126, SP-600125, and CsA. DNA fragmentation induced by ANG II was totally blocked by SP-600125, and CsA and was attenuated by U-0126. In rats with 0- to 20-day complete abdominal aorta ligation, the increases in IGF-II/IIR levels in the left ventricle were accompanied by hypertension as well as increases in caspase 9 activities and TUNEL-positive cardiac myocytes. ANG II-induced apoptosis was reversed by IGF-II/IIR blockade and coexisted with increased transactivation of IGF-II and -IIR, which are mediated by ERK and JNK pathways, respectively, both of which further contributed to cardiomyoblast apoptosis via calcineurin signaling. The increased cardiac IGF-II, IGF-IIR, caspase 9, and cellular apoptosis were also found in hypertensive rats with abdominal aorta ligation