3,821 research outputs found

    Transcriptional regulation of 11β-hydroxysteroid dehydrogenase type 1

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    Curating Queer Migrant Cinema:Interview between Sudeep Dasgupta and James S. Williams

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    This chapter comprises an extended interview with the influential theorist and practitioner of queer European migratory cinema, Sudeep Dasgupta. As well as a leading figure in queer/migrant studies based at the University of Amsterdam, Dasgupta is co-curator and programmer of the annual Dutch International Queer and Migrant Film Festival. He talks here in enlightening detail not only about the selection process and criteria for the annual festival, but also about the often fraught relations between lived queer migrant experience and theoretical critique. Engaging with some of the key common themes running throughout the volume, notably the value of the aesthetic in rendering the relational experience of migration, he also considers his own personal journey and location and how they have informed his critical work and intellectual project, including the particular paradoxes of the Dutch situation – an ultra-progressive and gay-friendly territory with a proud self-image as a tolerant ‘guiding nation’ (gidsland), yet where the faultlines of homonationalism are now acutely visible

    Identifying the mechanisms underpinning recognition of structured sequences of action

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    © 2012 The Experimental Psychology SocietyWe present three experiments to identify the specific information sources that skilled participants use to make recognition judgements when presented with dynamic, structured stimuli. A group of less skilled participants acted as controls. In all experiments, participants were presented with filmed stimuli containing structured action sequences. In a subsequent recognition phase, participants were presented with new and previously seen stimuli and were required to make judgements as to whether or not each sequence had been presented earlier (or were edited versions of earlier sequences). In Experiment 1, skilled participants demonstrated superior sensitivity in recognition when viewing dynamic clips compared with static images and clips where the frames were presented in a nonsequential, randomized manner, implicating the importance of motion information when identifying familiar or unfamiliar sequences. In Experiment 2, we presented normal and mirror-reversed sequences in order to distort access to absolute motion information. Skilled participants demonstrated superior recognition sensitivity, but no significant differences were observed across viewing conditions, leading to the suggestion that skilled participants are more likely to extract relative rather than absolute motion when making such judgements. In Experiment 3, we manipulated relative motion information by occluding several display features for the duration of each film sequence. A significant decrement in performance was reported when centrally located features were occluded compared to those located in more peripheral positions. Findings indicate that skilled participants are particularly sensitive to relative motion information when attempting to identify familiarity in dynamic, visual displays involving interaction between numerous features

    Optimization of superstructured fiber bragg gratings for microwave photonic filters response

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    The microwave photonic responses of superstructured fiber Bragg gratings in combination with dispersive fiber are investigated theoretically and experimentally. The superstructured gratings are optimized, taking account of the spectral response of the broad-band source, Erbium-doped fiber amplifier, and optical tunable filter to achieve a filter response with sidelobe suppression of more than 60 dB. © 2004 IEEE

    Experimental Assessment of Proximal Stent-graft (InterVascularTM) Fixation in Human Cadaveric Infrarenal Aortas

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    AbstractObjectivesthis paper investigates the radial deformation load of an aortic endoluminal prosthesis and determines the longitudinal load required to cause migration in a human cadaveric aorta of the endoprosthesis.Design and methodsthe endovascular prosthesis under investigation was a 24 mm diameter, nitinol, self-expanding aortoaortic device (InterVascular, Clearwater, Florida, U.S.A.). Initially, a motorised digital force gauge developed an incremental load which was applied to the ends of five stent-grafts, to a maximum of 10 mm (42%) compression. Secondly, using a simple bench model, each end of four stent-grafts were deployed into 10 cadaveric experimental aneurysm necks and a longitudinal load applied to effect distraction.Resultsincreasing load produced increasing percentage deformation of the stent-grafts. The mean longitudinal distraction load for an aneurysm neck of 20 mm was 409 g (200–480 g), for 15 mm was 277 g (130–410 g) and for 10 mm was 218 g (130–340 g). The aneurysm diameter and aortic calcification hadpvalues of 0.002 and 0.047, respectively, while thepvalue for aneurysm neck length was less than 0.00001.Conclusionsthese results suggest that there is a theoretical advantage of oversizing an aortic prosthesis and that sufficient anchorage is achieved in an aortic neck of 10 mm to prevent migration when fully deployed

    Universal screening for meticillin-resistant Staphylococcus aureus : interim results from the NHS Scotland pathfinder project

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    Following recommendations from a Health Technology Assessment (HTA), a prospective cohort study of meticillin-resistant Staphylococcus aureus (MRSA) screening of all admissions (N = 29 690) to six acute hospitals in three regions in Scotland indicated that 7.5% of patientswere colonised on admission to hospital. Factors associated with colonisation included re-admission, specialty of admission (highest in nephrology, care of the elderly, dermatology and vascular surgery), increasing age, and the source of admission (care home or other hospital). Three percent of all those who were identified as colonised developed hospital-associated MRSA infection, compared with only 0.1% of those not colonised. Specialtieswith a high rate of colonisation on admission also had higher rates of MRSA infection. Very few patients refused screening (11 patients, 0.03%) or had treatment deferred (14 patients, 0.05%). Several organisational issues were identified, including difficulties in achieving complete uptake of screening (88%) or decolonisation (41%); the latter was largely due to short duration of stay and turnaround time for test results. Patient movement resulted in a decision to decontaminate all positive patients rather than just those in high risk specialties as proposed by the HTA. Issues also included a lack of isolation facilities to manage patients with MRSA. The study raises significant concerns about the contribution of decolonisation to reducing risks in hospital due to short duration of stay, and reinforces the central role of infection control precautions. Further study is required before the HTA model can be re-run and conclusions redrawn on the cost and clinical effectiveness of universal MRSA screening

    A new method for microwave generation and data transmission using DFB laser based on fiber bragg gratings

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    A novel architecture for microwave/millimeter-wave signal generation and data modulation using a fiber-grating-based distributed feedback laser has been proposed in this letter. For demonstration, a 155.52-Mb/s data stream on a 16.9-GHz subcarrier has been transmitted and recovered successfully. It has been proved that this technology would be of benefit to future microwave data transmission systems. © 2006 IEEE

    Addressing the clumsiness loophole in a Leggett-Garg test of macrorealism

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    The rise of quantum information theory has lent new relevance to experimental tests for non-classicality, particularly in controversial cases such as adiabatic quantum computing superconducting circuits. The Leggett-Garg inequality is a "Bell inequality in time" designed to indicate whether a single quantum system behaves in a macrorealistic fashion. Unfortunately, a violation of the inequality can only show that the system is either (i) non-macrorealistic or (ii) macrorealistic but subjected to a measurement technique that happens to disturb the system. The "clumsiness" loophole (ii) provides reliable refuge for the stubborn macrorealist, who can invoke it to brand recent experimental and theoretical work on the Leggett-Garg test inconclusive. Here, we present a revised Leggett-Garg protocol that permits one to conclude that a system is either (i) non-macrorealistic or (ii) macrorealistic but with the property that two seemingly non-invasive measurements can somehow collude and strongly disturb the system. By providing an explicit check of the invasiveness of the measurements, the protocol replaces the clumsiness loophole with a significantly smaller "collusion" loophole.Comment: 7 pages, 3 figure

    The Complex Topology of Chemical Plants

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    We show that flowsheets of oil refineries can be associated to complex network topologies that are scale-free, display small-world effect and possess hierarchical organization. The emergence of these properties from such man-made networks is explained as a consequence of the currently used principles for process design, which include heuristics as well as algorithmic techniques. We expect these results to be valid for chemical plants of different types and capacities.Comment: 7 pages, 5 figures and 1 tabl

    Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT(1A) agonist in rat models of ischaemic stroke.

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    RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.BACKGROUND: 5HT1A agonists have previously been shown to promote recovery in animal models of stroke using ex vivo outcome measures which have raised the hopes for a potential clinical implementation. The purpose of this study was to evaluate the potential neuroprotective properties of a novel 5HT1A agonist DU123015 in 2 different models of transient focal ischaemic stroke of varying severities using both in vivo neuroimaging and behavioural techniques as primary outcome measures. For these studies, the NMDA receptor antagonist MK-801 was also utilized as a positive control to further assess the effectiveness of the stroke models and techniques used. RESULTS: In contrast to MK-801, no significant therapeutic effect of DU123015 on lesion volume in either the distal MCAo or intraluminal thread model of stroke was found. MK-801 significantly reduced lesion volume in both models; the mild distal MCAo condition (60 min ischaemia) and the intraluminal thread model, although it had no significant impact upon the lesion size in the severe distal MCAo condition (120 min ischaemia). These therapeutic effects on lesion size were mirrored on a behavioural test for sensory neglect and neurological deficit score in the intraluminal thread model. CONCLUSION: This study highlights the need for a thorough experimental design to test novel neuroprotective compounds in experimental stroke investigations incorporating: a positive reference compound, different models of focal ischaemia, varying the duration of ischaemia, and objective in vivo assessments within a single study. This procedure will help us to minimise the translation of less efficacious compounds
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