21 research outputs found
Prospects for e+e- physics at Frascati between the phi and the psi
We present a detailed study, done in the framework of the INFN 2006 Roadmap,
of the prospects for e+e- physics at the Frascati National Laboratories. The
physics case for an e+e- collider running at high luminosity at the phi
resonance energy and also reaching a maximum center of mass energy of 2.5 GeV
is discussed, together with the specific aspects of a very high luminosity
tau-charm factory. Subjects connected to Kaon decay physics are not discussed
here, being part of another INFN Roadmap working group. The significance of the
project and the impact on INFN are also discussed. All the documentation
related to the activities of the working group can be found in
http://www.roma1.infn.it/people/bini/roadmap.html.Comment: INFN Roadmap Report: 86 pages, 25 figures, 9 table
Congenital malformations in the fylde region of Lancashire, England 1957-1973
This paper uses data collected by a consultant paediatrician to examine variations in the prevalence of neural tube and cardiovascular malformations within the Fylde region of North West England. Results at the district scale indicate contrasts in the geographical distributions of the two classes of malformation and these are then further assessed via a case-control study which standardises for factors such as date of conception, age of mother and parity. The results of this study suggest that there were wards in Blackpool and Fleetwood with unusually high prevalences of neural tube defects. Further research is being undertaken to identify the causes of these concentrations.congenital malformations prevalence geographical variations Poisson probabilities case- control study
Congenital malformations associated with anencephaly in the Fylde peninsula of Lancashire.
Seasonal prevalence of major congenital malformations in the Fylde of Lancaster 1957-1981
The seasonal prevalence of major congenital malformations was studied in a prospective survey of 88,449 children born in the circumscribed Fylde of Lancashire to residents there over 25 years. Ascertainment was thought to be as complete as was practically possible because cases were recorded daily by one, and for 17 years the only, paediatrician and a very high rate of necropsies was maintained. The number of malformations were classified by month of maternal last menstrual period and seasonal variation was assessed by three statistical models. Neural tube defects showed a significant seasonal variation in month of last menstrual period but not in month of birth. From May 1956 to April 1968, when the prevalence of neural tube defects was high (5.5 per 1000 total births), conceptions were significantly more common in December to May. For anencephaly alone the figures were not significant, but spina bifida and cranium bifidum were more common in March to May. From May 1968 to April 1981, when the prevalence of neural tube defects fell below the national average, the significant variations disappeared. Seasonality for spina bifida and cranium bifidum was seen only in "singles" (cases with no other major lesion), but for anencephaly it was seen only in "multiples" (cases with other lesions). The three types of cardiac septal defect and persistent ductus each showed a higher prevalence of conceptions at some time during May to October. In contrast the commonest group of cyanotic cases showed no such pattern but with greater numbers in winter. There was evidence of a seasonal variation for bilateral renal agenesis and for vesicoureteric reflux as ascertained. Seasonal prevalence in an aetiological factor for certain malformations of the central nervous system, cardiac and urinary systems
The presentation of symptomatic heart disease in infancy based on 10 years' experience (1973-82). Implications for the provision of services.
How do Brandsâ âOwn Genericsâ Affect Pharmaceutical Prices?
This paper examines the price effects of generic drugs that are produced by brand-name drug firms and that are labeled, priced, and marketed to compete against independent generics. The strategy of introducing such âpseudo-genericsâ â also known as âauthorized genericsâ â has raised some antitrust concerns. One defense of this strategy has been that the additional competition created by pseudo-generics should lead to lower prices. This paper develops a simple model to show that pseudo-generics can be expected to have exactly the opposite effect. It then examines empirical evidence on this point from the Canadian pharmaceutical market, showing that there appears to be a positive relationship between drug prices and the share of generic sales made by the brandâs own pseudo-generic. Copyright Springer 2005Competition, generics, pharmaceuticals, L12, I18,