Die verhouding tussen openbaring, dogmavorming en doksa-uiting in die himniese stof van die Nuwe Testament

The relation between revelation, the formation of dogma and the expression of doxa in the hymnal matter of the New Testament This article proceeds from the central theoretical argument that in the liturgical song an integral relation exists between revelation, the formation of confession (dogma) and the expression of glory (doxa). The purpose of the article is to analyse the mentioned relationship as it becomes manifest in the hymnal matter of the New Testament and to determine its significance in the hymnal action of the community of worshippers. It is kept in mind that the New Testament, unlike the Old Testament, does not contain a book of songs and that the number of complete songs is limited. The article thus also focuses on song fragments. The conclusion arrived at is that the song material of the New Testament indicates that the revelation stands in a causal relation to dogma formation and doxa expression that occur in the liturgical song. Dogma formation and doxa expression respond to the revelation and actualize the revelation, while these two vital elements of the hymnal content (dogma formation and doxa expression) stand in a convergent and symbiotic relation to each other. The result of this investigation appears to be important for the meaningful use of New Testament songs in contemporary liturgy

Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract

Murine γ-herpesvirus 68 (MHV-68) infection of Mus musculus-derived strains of mice is an established model of γ-herpesvirus infection. We have previously developed an alternative system using a natural host, the wood mouse (Apodemus sylvaticus), and shown that the MHV-68 M3 chemokine-binding protein contributes significantly to MHV-68 pathogenesis. Here we demonstrate in A. sylvaticus using high-density micro-arrays that M3 influences the expression of genes involved in the host response including Scgb1a1 and Bpifa1 that encode potential innate defense proteins secreted into the respiratory tract. Further analysis of MHV-68-infected animals showed that the levels of both protein and RNA for SCGB1A1 and BPIFA1 were decreased at day 7 post infection (p.i.) but increased at day 14 p.i. as compared with M3-deficient and mock-infected animals. The modulation of expression was most pronounced in bronchioles but was also present in the bronchi and trachea. Double staining using RNA in situ hybridization and immunohistology demonstrated that much of the BPIFA1 expression occurs in club cells along with SCGB1A1 and that BPIFA1 is stored within granules in these cells. The increase in SCGB1A1 and BPIFA1 expression at day 14 p.i. was associated with the differentiation of club cells into mucus-secreting cells. Our data highlight the role of club cells and the potential of SCGB1A1 and BPIFA1 as innate defense mediators during respiratory virus infection

Die verhouding tussen openbaring, dogmavorming en doksa-uiting in die himniese stof van die Nuwe Testament

The relation between revelation, the formation of dogma and the expression of doxa in the hymnal matter of the New Testament This article proceeds from the central theoretical argument that in the liturgical song an integral relation exists between revelation, the formation of confession (dogma) and the expression of glory (doxa). The purpose of the article is to analyse the mentioned relationship as it becomes manifest in the hymnal matter of the New Testament and to determine its significance in the hymnal action of the community of worshippers. It is kept in mind that the New Testament, unlike the Old Testament, does not contain a book of songs and that the number of complete songs is limited. The article thus also focuses on song fragments. The conclusion arrived at is that the song material of the New Testament indicates that the revelation stands in a causal relation to dogma formation and doxa expression that occur in the liturgical song. Dogma formation and doxa expression respond to the revelation and actualize the revelation, while these two vital elements of the hymnal content (dogma formation and doxa expression) stand in a convergent and symbiotic relation to each other. The result of this investigation appears to be important for the meaningful use of New Testament songs in contemporary liturgy.http://dx.doi.org/10.4102/ids.v37i2.464http://www.inluceverbi.org.za/index.php/skriflig/article/viewFile/464/35

DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis*

Tissue homeostasis requires a carefully-orchestrated balance between cell proliferation, cellular senescence and cell death. Cells proliferate through a cell cycle that is tightly regulated by cyclin-dependent kinase activities. Cellular senescence is a safeguard program limiting the proliferative competence of cells in living organisms. Apoptosis eliminates unwanted cells by the coordinated activity of gene products that regulate and effect cell death. The intimate link between the cell cycle, cellular senescence, apoptosis regulation, cancer development and tumor responses to cancer treatment has become eminently apparent. Extensive research on tumor suppressor genes, oncogenes, the cell cycle and apoptosis regulatory genes has revealed how the DNA damage-sensing and -signaling pathways, referred to as the DNA-damage response network, are tied to cell proliferation, cell-cycle arrest, cellular senescence and apoptosis. DNA-damage responses are complex, involving “sensor” proteins that sense the damage, and transmit signals to “transducer” proteins, which, in turn, convey the signals to numerous “effector” proteins implicated in specific cellular pathways, including DNA repair mechanisms, cell-cycle checkpoints, cellular senescence and apoptosis. The Bcl-2 family of proteins stands among the most crucial regulators of apoptosis and performs vital functions in deciding whether a cell will live or die after cancer chemotherapy and irradiation. In addition, several studies have now revealed that members of the Bcl-2 family also interface with the cell cycle, DNA repair/recombination and cellular senescence, effects that are generally distinct from their function in apoptosis. In this review, we report progress in understanding the molecular networks that regulate cell-cycle checkpoints, cellular senescence and apoptosis after DNA damage, and discuss the influence of some Bcl-2 family members on cell-cycle checkpoint regulation