UBA1: At the Crossroads of Ubiquitin Homeostasis and Neurodegeneration

Neurodegenerative diseases are a leading cause of disability and early death. A common feature of these conditions is disruption of protein homeostasis. Ubiquitin-like modifier activating enzyme 1 (UBA1), the E1 ubiquitin-activating enzyme, sits at the apex of the ubiquitin cascade and represents an important regulator of cellular protein homeostasis. Critical contributions of UBA1-dependent pathways to the regulation of homeostasis and degeneration in the nervous system are emerging, including specific disruption of UBA1 in spinal muscular atrophy (SMA) and Huntington's disease (HD). In this review we discuss recent findings that put UBA1 at the centre of cellular homeostasis and neurodegeneration, highlighting the potential for UBA1 to act as a promising therapeutic target for a range of neurodegenerative diseases

UGC 12732: A Disk Galaxy Lacking High-Velocity Clouds

We used the Very Large Array to obtain high-sensitivity 21cm synthesis images of the disk galaxy UGC 12732. This object did not show high-velocity wings in Arecibo telescope spectra obtained to search for populations of high-velocity clouds in external galaxies.Peer reviewe

High-Velocity H I in the Spiral Galaxy NGC 5668

Original article can be found at: http://adsabs.harvard.edu/ Copyright American Astronomical Society. DOI: 10.1086/118070 [Full text of this article is not available in the UHRA]The nature and origin of the high-velocity clouds (HVCs) of neutral hydrogen in our Galaxy are not well understood, in part because of the uncertain distances to the clouds. As a result it is difficult to measure the mass of neutral hydrogen in the HVCs in the Galaxy, but further insight into the nature of HVCs can be obtained by finding and studying such gas in other galaxies. The Sc-galaxy NGC 5668 was found to have high-velocity wings beyond the double-horned 21 cm profile in observations performed with the Arecibo 305 m telescope; these wings are the expected signature of HVCs in a disk galaxy. In this paper, Very Large Array observations of NGC 5668 are presented that confirm the high- velocity H I wings detected with the Arecibo telescope. About 60% of the material in the high-velocity wings is distinct in position-velocity diagrams, located primarily outside the optical disk of the galaxy, and may be infalling material comparable to the Magellanic Stream in our own Galaxy. The total mass of this kinematically distinct neutral hydrogen is 4 x 10^8^ M_sun_. A natural source for the rest of the wing material is halo gas produced by a galactic fountain. Such a fountain would be driven by supernovae and energetic stellar winds from massive stars in OB associations that would also transfer kinetic energy to the neutral hydrogen disk. This would result in a larger H I velocity dispersion within the optical disk than outside of it, as is suggested by these observations.Peer reviewe

Renal duplications: The impact of perinatal ultrasound on diagnosis and management

SCOPUS: ar.jinfo:eu-repo/semantics/publishe