Stability improvement of a laser-accelerated electron beam and the pulse width measurement of the electron beam

Laser wakefield acceleration has the possibility to generate an ultrashort electron beam of the order of femtoseconds or less. In applications of these laser accelerated electron beams, stable and controllable electron beams are necessary. A high stability electron bunch is generated by laser wakefield acceleration with the help of a colliding laser pulse (optical injection). Stable and monoenergetic electron beams have been generated in the self-injection scheme of laser acceleration by using a Nitrogen gas jet target. The electron interaction with the laser field results in transverse oscillations of the electron beam. From the electron oscillation period dependence on the electron energy we find that the electron beam width is equal to 1.7 fs (rms).В процессе ускорения кильватерными волнами возможна генерация сверхкоротких электронных пучков фемтосекундной длительностью. Для приложений требуются электронные пучки с воспроизводимыми и котролируемыми параметрами. Оптическая инжекция, использующая сталкивающиеся лазерные импульсы, обеспечивает высокую воспроизводимость параметров пучков ускоренных электронов. Моноэнергетические пучки электронов с воспроизводимыми параметрами были получены при «самоинжекции» в кильватерную волну в экспериментах, использующих в качестве мишени струю азота. Взаимодействие электронов с излучением лазерного импульса приводит к поперечным осцилляциям электронного пучка. Анализ наблюдаемой в эксперименте зависимости периода осцилляций от энергии электронов позволяет найти длительность электронного пучка, равную 1.7 фс.В процесі прискорення кільватерними хвилями можлива генерація надкоротких електронних пучків фемтосекундної тривалості. Для додатків потрібні електронні пучки з відтворюючими і котролюючими параметрами. Оптична інжекція, що використовує зіштовхуючі лазерні імпульси, забезпечує високу відтворюваність параметрів пучків прискорених електронів. Моноенергетичні пучки електронів з відтворюваними параметрами були отримані при «самоінжекції» в кільватерну хвилю в експериментах, в яких в якості мішені використовувалася струмінь азоту. Взаємодія електронів з випромінюванням лазерного імпульсу призводить до поперечних осциляцій електронного пучка. Аналіз спостерігаючої в експерименті залежності періоду осциляцій від енергії електронів дозволяє знайти тривалість електронного пучка, яка дорівнює 1.7 фс

Observation of Burst Intensification by Singularity Emitting Radiation generated from relativistic plasma with a high-intensity laser

Coherent x-rays via the Burst Intensification by Singularity Emitting Radiation (BISER) mechanism are generated from relativistic plasma in helium gas target. A broad modulation of the BISER spectrum, which is significantly wider than the harmonic order, is observed and characterized. In particular, we found that the modulation period can be as large as 41 eV

High order harmonics from relativistic electron spikes

A new regime of relativistic high-order harmonic generation is discovered [Phys. Rev. Lett. 108, 135004 (2012)]. Multi-terawatt relativistic-irradiance (>1018 W/cm2) femtosecond (~30-50 fs) lasers focused to underdense (few×1019 cm-3) plasma formed in gas jet targets produce comb-like spectra with hundreds of even and odd harmonic orders reaching the photon energy of 360 eV, including the 'water window' spectral range. Harmonics are generated by either linearly or circularly polarized pulses from the J-KAREN (KPSI, JAEA) and Astra Gemini (CLF, RAL, UK) lasers. The photon number scalability has been demonstrated with a 120 TW laser producing 40 μJ/sr per harmonic at 120 eV. The experimental results are explained using particle-in-cell (PIC) simulations and catastrophe theory. A new mechanism of harmonic generation by sharp, structurally stable, oscillating electron spikes at the joint of boundaries of wake and bow waves excited by a laser pulse is introduced. In this paper detailed descriptions of the experiments, simulations and model are provided and new features are shown, including data obtained with a two-channel spectrograph, harmonic generation by circularly polarized laser pulses and angular distribution

Optical Constants of Ices Important to Planetary Science From Laboratory Reflectance Spectroscopy

Laboratory-derived optical constants are essential for identifying ices and measuring their relative abundances on Solar System objects. Almost all optical constants of ices important to planetary science come from experiments with transmission geometries. Here, we describe our new experimental setup and the modification of an iterative algorithm in the literature to measure the optical constants of ices from experiments with reflectance geometries. We apply our techniques to CH4 ice and H2O ice samples and find good agreement between our values and those in the literature, except for one CH4 band in the literature that likely suffers from saturation. The work we present here demonstrates that labs with reflectance geometries can generate optical constants essential for the proper analysis of near- and mid-infrared spectra of outer Solar System objects such as those obtained with the James Webb Space Telescope

Optical Constants of Ices Important to Planetary Science From Laboratory Reflectance Spectroscopy

Laboratory-derived optical constants are essential for identifying ices and measuring their relative abundances on Solar System objects. Almost all optical constants of ices important to planetary science come from experiments with transmission geometries. Here, we describe our new experimental setup and the modification of an iterative algorithm in the literature to measure the optical constants of ices from experiments with reflectance geometries. We apply our techniques to CH4 ice and H2O ice samples and find good agreement between our values and those in the literature, except for one CH4 band in the literature that likely suffers from saturation. The work we present here demonstrates that labs with reflectance geometries can generate optical constants essential for the proper analysis of near- and mid-infrared spectra of outer Solar System objects such as those obtained with the James Webb Space Telescope

Track A Basic Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138319/1/jia218438.pd

Atorvastatin induces associated reductions in platelet P-selectin, oxidized low-density lipoprotein, and interleukin-6 in patients with coronary artery diseases.

The development and progression of atherosclerosis comprises various processes, such as endothelial dysfunction, chronic inflammation, thrombus formation, and lipid profile modification. Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors that have pleiotropic effects in addition to cholesterol-lowering properties. However, the mechanisms of these effects are not completely understood. Here, we investigated whether atorvastatin affects the levels of malondialdehyde-modified low-density lipoprotein (MDALDL), an oxidized LDL, the proinflammatory cytokine interleukin-6 (IL-6), or platelet P-selectin, a marker of platelet activation, relative to that of LDL cholesterol (LDL-C). Forty-eight patients with coronary artery disease and hyperlipidemia were separated into two groups that were administered with (atorvastatin group) or without (control group) atorvastatin. The baseline MDA-LDL level in all participants significantly correlated with LDL-C (r = 0.71, P < 0.01) and apolipoprotein B levels (r = 0.66, P < 0.01). Atorvastatin (10 mg/day) significantly reduced the LDL-C level within 4 weeks and persisted for a further 8 weeks of administration. Atorvastatin also reduced the MDA-LDL level within 4 weeks and further reduced it over the next 8 weeks. Platelet P-selectin expression did not change until 4 weeks of administration and then significantly decreased at 12 weeks, whereas the IL-6 level was gradually, but not significantly, reduced at 12 weeks. In contrast, none of these parameters significantly changed in the control group within these time frames. The reduction (%) in IL-6 between 4 and 12 weeks after atorvastatin administration significantly correlated with that of MDALDL and of platelet P-selectin (r = 0.65, P < 0.05 and r = 0.70, P < 0.05, respectively). These results suggested that the positive effects of atorvastatin on the LDL-C oxidation, platelet activation and inflammation that are involved in atherosclerotic processes are exerted in concert after lowering LDL-C

Laboratory Measurement of Volatile Ice Vapor Pressures With a Quartz Crystal Microbalance

Nitrogen, carbon monoxide, and methane are key materials in the far outer Solar System where their high volatility enables them to sublimate, potentially driving activity at very low temperatures. Knowledge of their vapor pressures and latent heats of sublimation at relevant temperatures is needed to model the processes involved. We describe a method for using a quartz crystal microbalance to measure the sublimation flux of these volatile ices in the free molecular flow regime, accounting for the simultaneous sublimation from and condensation onto the quartz crystal to derive vapor pressures and latent heats of sublimation. We find vapor pressures to be somewhat lower than previous estimates in literature, with carbon monoxide being the most discrepant of the three species, almost an order of magnitude lower than had been thought. These results have important implications across a variety of astrophysical and planetary environments