Identificacion of transthyretin and β4 thymosin as potential biomarkers in aucte coronary syndrome by two independent methods, 2-DE/DIGE and SELDI/TOF

Comunicaciones a congreso

Matkailutyö

Matkailututkimus – mitkä ovat sen keskeiset käsitteet ja millaisiin tutkimusperinteisiin ne pohjautuvat? Millaista uutta tutkimusta tarvitaan? Matkailututkimuksen avainkäsitteet luo kehykset ja perustan matkailun moni- ja poikkitieteiselle tutkimukselle. Se rakentaa eri aloilta tuleville tutkijoille yhteisen käsitteistön ja auttaa näin ymmärtämään matkailua monimuotoisena paikallisena ja globaalina voimana. Vasta yhteisen ymmärryksen pohjalta matkailututkimus voi vakiintua varteenotettavaksi tieteenalaksi. Yhtä laajaa suomenkielistä teosta ei matkailututkimuksesta ole aikaisemmin julkaistu. Tämän laajasti vertaisarvioidun kirjan kirjoittajina on 42 asiantuntijaa yliopistoista, ammattikorkeakouluista ja tutkimuslaitoksista eri puolilta Suomea

Mitochondrial functions on oocytes and preimplantation embryos*

Oocyte quality has long been considered as a main limiting factor for in vitro fertilization (IVF). In the past decade, extensive observations demonstrated that the mitochondrion plays a vital role in the oocyte cytoplasm, for it can provide adenosine triphosphate (ATP) for fertilization and preimplantation embryo development and also act as stores of intracellular calcium and proapoptotic factors. During the oocyte maturation, mitochondria are characterized by distinct changes of their distribution pattern from being homogeneous to heterogeneous, which is correlated with the cumulus apoptosis. Oocyte quality decreases with the increasing maternal age. Recent studies have shown that low quality oocytes have some age-related dysfunctions, which include the decrease in mitochondrial membrane potential, increase of mitochondrial DNA (mtDNA) damages, chromosomal aneuploidies, the incidence of apoptosis, and changes in mitochondrial gene expression. All these dysfunctions may cause a high level of developmental retardation and arrest of preimplantation embryos. It has been suggested that these mitochondrial changes may arise from excessive reactive oxygen species (ROS) that is closely associated with the oxidative energy production or calcium overload, which may trigger permeability transition pore opening and subsequent apoptosis. Therefore, mitochondria can be seen as signs for oocyte quality evaluation, and it is possible that the oocyte quality can be improved by enhancing the physical function of mitochondria. Here we reviewed recent advances in mitochondrial functions on oocytes