30 research outputs found

    Cortex commands the performance of skilled movement

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    Mammalian cerebral cortex is accepted as being critical for voluntary motor control, but what functions depend on cortex is still unclear. Here we used rapid, reversible optogenetic inhibition to test the role of cortex during a head-fixed task in which mice reach, grab, and eat a food pellet. Sudden cortical inhibition blocked initiation or froze execution of this skilled prehension behavior, but left untrained forelimb movements unaffected. Unexpectedly, kinematically normal prehension occurred immediately after cortical inhibition, even during rest periods lacking cue and pellet. This ‘rebound’ prehension was only evoked in trained and food-deprived animals, suggesting that a motivation-gated motor engram sufficient to evoke prehension is activated at inhibition’s end. These results demonstrate the necessity and sufficiency of cortical activity for enacting a learned skill

    Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage

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    Discussion: Strictly lobar MBs strongly predict CAA in non-ICH individuals when found in a hospital context. However, their diagnostic accuracy in the general population appears limited. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.Paroxysmal Cerebral Disorder

    A Trinomial Logit Analysis of Household Composition

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    This article analyzes the effects on the marriage and household composition decisions of characteristics of the householder and of the place of residence. High housing costs reduced the probability of living alone. For female householders, increases in income decreased the probability of living alone rather than with unrelated individuals; the reverse was true for male householders. An increase in income decreased the probability of marriage for female householders over twenty-three years of age and increased the probability of marriage for male householders. Non-white householders over forty were less likely to be married than white householders over forty. Copyright American Real Estate and Urban Economics Association.
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