986 research outputs found
Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model
Practically, all chemotherapeutic agents lead to drug resistance. Clinically,
it is a challenge to determine whether resistance arises prior to, or as a
result of, cancer therapy. Further, a number of different intracellular and
microenvironmental factors have been correlated with the emergence of drug
resistance. With the goal of better understanding drug resistance and its
connection with the tumor microenvironment, we have developed a hybrid
discrete-continuous mathematical model. In this model, cancer cells described
through a particle-spring approach respond to dynamically changing oxygen and
DNA damaging drug concentrations described through partial differential
equations. We thoroughly explored the behavior of our self-calibrated model
under the following common conditions: a fixed layout of the vasculature, an
identical initial configuration of cancer cells, the same mechanism of drug
action, and one mechanism of cellular response to the drug. We considered one
set of simulations in which drug resistance existed prior to the start of
treatment, and another set in which drug resistance is acquired in response to
treatment. This allows us to compare how both kinds of resistance influence the
spatial and temporal dynamics of the developing tumor, and its clonal
diversity. We show that both pre-existing and acquired resistance can give rise
to three biologically distinct parameter regimes: successful tumor eradication,
reduced effectiveness of drug during the course of treatment (resistance), and
complete treatment failure
Mixed mode data clustering: an approach based on tectrachoric correlations
In this paper we face the problem of clustering mixedmode data by assuming that the observed binary variables aregenerated from latent continuous variables. We perform a principalcomponents analysis on the matrix of tetrachoric correlations and wethen estimate the scores of each latent variable and construct adata matrix with continuous variables to be used in fully Guassianmixture models or in the k-means cluster analysis. The calculationof the expected a posteriori (EAP) estimates may proceed by simplyconsidering a limited number of quadrature points. Results on asimulation study and on a real data set are reported
Experimental Critical Current Patterns in Josephson Junction Ladders
We present an experimental and theoretical study of the magnetic field
dependence of the critical current of Josephson junction ladders. At variance
with the well-known case of a one-dimensional (1D) parallel array of Josephson
junctions the magnetic field patterns display a single minimum even for very
low values of the self-inductance parameter . Experiments
performed changing both the geometrical value of the inductance and the
critical current of the junctions show a good agreement with numerical
simulations. We argue that the observed magnetic field patterns are due to a
peculiar mapping between the isotropic Josephson ladder and the 1D parallel
array with the self-inductance parameter .Comment: 4 pages, 4 picture
Fibre Inflation: Observable Gravity Waves from IIB String Compactifications
We introduce a simple string model of inflation, in which the inflaton field
can take trans-Planckian values while driving a period of slow-roll inflation.
This leads naturally to a realisation of large field inflation, inasmuch as the
inflationary epoch is well described by the single-field scalar potential . Remarkably, for a broad class of vacua
all adjustable parameters enter only through the overall coefficient , and
in particular do not enter into the slow-roll parameters. Consequently these
are determined purely by the number of \e-foldings, , and so are not
independent: . This implies similar
relations among observables like the primordial scalar-to-tensor amplitude,
, and the scalar spectral tilt, : . is
itself more model-dependent since it depends partly on the post-inflationary
reheat history. In a simple reheating scenario a reheating temperature of
GeV gives , corresponding to and , within reach of future observations. The model is
an example of a class that arises naturally in the context of type IIB string
compactifications with large-volume moduli stabilisation, and takes advantage
of the generic existence there of Kahler moduli whose dominant appearance in
the scalar potential arises from string loop corrections to the Kahler
potential. The inflaton field is a combination of Kahler moduli of a K3-fibered
Calabi-Yau manifold. We believe there are likely to be a great number of models
in this class -- `high-fibre models' -- in which the inflaton starts off far
enough up the fibre to produce observably large primordial gravity waves.Comment: Extended calculations beyond the leading approximations, including
numerical integrations of multi-field evolution; Display an example with ; Simplify the discussion of large fields; Corrected minor errors and
typos; Added references; 41 pages LaTeX, 25 figure
Measuring CMB Polarization with BOOMERANG
BOOMERANG is a balloon-borne telescope designed for long duration (LDB)
flights around Antarctica. The second LDB Flight of BOOMERANG took place in
January 2003. The primary goal of this flight was to measure the polarization
of the CMB. The receiver uses polarization sensitive bolometers at 145 GHz.
Polarizing grids provide polarization sensitivity at 245 and 345 GHz. We
describe the BOOMERANG telescope noting changes made for 2003 LDB flight, and
discuss some of the issues involved in the measurement of polarization with
bolometers. Lastly, we report on the 2003 flight and provide an estimate of the
expected results.Comment: 12 pages, 8 figures, To be published in the proceedings of "The
Cosmic Microwave Background and its Polarization", New Astronomy Reviews,
(eds. S. Hanany and K.A. Olive). Fixed typos, and reformatted citation
SPIDER: Probing the Early Universe with a Suborbital Polarimeter
We evaluate the ability of SPIDER, a balloon-borne polarimeter, to detect a
divergence-free polarization pattern ("B-modes") in the Cosmic Microwave
Background (CMB). In the inflationary scenario, the amplitude of this signal is
proportional to that of the primordial scalar perturbations through the
tensor-to-scalar ratio r. We show that the expected level of systematic error
in the SPIDER instrument is significantly below the amplitude of an interesting
cosmological signal with r=0.03. We present a scanning strategy that enables us
to minimize uncertainty in the reconstruction of the Stokes parameters used to
characterize the CMB, while accessing a relatively wide range of angular
scales. Evaluating the amplitude of the polarized Galactic emission in the
SPIDER field, we conclude that the polarized emission from interstellar dust is
as bright or brighter than the cosmological signal at all SPIDER frequencies
(90 GHz, 150 GHz, and 280 GHz), a situation similar to that found in the
"Southern Hole." We show that two ~20-day flights of the SPIDER instrument can
constrain the amplitude of the B-mode signal to r<0.03 (99% CL) even when
foreground contamination is taken into account. In the absence of foregrounds,
the same limit can be reached after one 20-day flight.Comment: 29 pages, 8 figures, 4 tables; v2: matches published version, flight
schedule updated, two typos fixed in Table 2, references and minor
clarifications added, results unchange
Vector meson production and nucleon resonance analysis in a coupled-channel approach for energies m_N < sqrt(s) < 2 GeV II: photon-induced results
We present a nucleon resonance analysis by simultaneously considering all
pion- and photon-induced experimental data on the final states gamma N, pi N, 2
pi N, eta N, K Lambda, K Sigma, and omega N for energies from the nucleon mass
up to sqrt(s) = 2 GeV. In this analysis we find strong evidence for the
resonances P_{31}(1750), P_{13}(1900), P_{33}(1920), and D_{13}(1950). The
omega N production mechanism is dominated by large P_{11}(1710) and
P_{13}(1900) contributions. In this second part we present the results on the
photoproduction reactions and the electromagnetic properties of the resonances.
The inclusion of all important final states up to sqrt(s) = 2 GeV allows for
estimates on the importance of the individual states for the GDH sum rule.Comment: 41 pages, 26 figures, discussion extended, typos corrected,
references updated, to appear in Phys. Rev.
First Results from the Arcminute Cosmology Bolometer Array Receiver
We review the first science results from the Arcminute Cosmology Bolometer
Array Receiver (ACBAR); a multifrequency millimeter-wave receiver optimized for
observations of the Cosmic Microwave Background (CMB) and the
Sunyaev-Zel'dovich (SZ) effect in clusters of galaxies. ACBAR was installed on
the 2 m Viper telescope at the South Pole in January 2001 and the results
presented here incorporate data through July 2002. We present the power
spectrum of the CMB at 150 GHz over the range \ell = 150 - 3000 measured by
ACBAR as well as estimates for the values of the cosmological parameters within
the context of Lambda-CDM models. We find that the inclusion of Omega_Lambda
greatly improves the fit to the power spectrum. We also observe a slight excess
of small-scale anisotropy at 150 GHz; if interpreted as power from the SZ
effect of unresolved clusters, the measured signal is consistent with CBI and
BIMA within the context of the SZ power spectrum models tested.Comment: To be published in the proceedings of "The Cosmic Microwave
Background and its Polarization", New Astronomy Reviews, (eds. S. Hanany and
K.A. Olive). 10 pages, 2 figure
Taxonomic surrogacy in biodiversity assessments, and the meaning of Linnaean ranks
Copyright © 2006 The Natural History MuseumThe majority of biodiversity assessments use species as the base unit. Recently, a series of studies have suggested replacing numbers of species with higher ranked taxa (genera, families, etc.); a method known as taxonomic surrogacy that has an important potential to save time and resources in assesments of biological diversity. We examine the relationships between taxa and ranks, and suggest that species/higher taxon exchanges are founded on misconceptions about the properties of Linnaean classification. Rank allocations in current classifications constitute a heterogeneous mixture of various historical and contemporary views. Even if all taxa were monophyletic, those referred to the same rank would simply denote separate clades without further equivalence. We conclude that they are no more comparable than any other, non-nested taxa, such as, for example, the genus Rattus and the phylum Arthropoda, and that taxonomic surrogacy lacks justification. These problems are also illustrated with data of polychaetous annelid worms from a broad-scale study of benthic biodiversity and species distributions in the Irish Sea. A recent consensus phylogeny for polychaetes is used to provide three different family-level classifications of polychaetes. We use families as a surrogate for species, and present ShannonâWiener diversity indices for the different sites and the three different classifications, showing how the diversity measures rely on subjective rank allocations.Y. Bertrand, F. Pleijel and G. W. Rous
The BOOMERanG experiment and the curvature of the Universe
We describe the BOOMERanG experiment and its main result, i.e. the
measurement of the large scale curvature of the Universe. BOOMERanG is a
balloon-borne microwave telescope with sensitive cryogenic detectors. BOOMERanG
has measured the angular distribution of the Cosmic Microwave Background on
of the sky, with a resolution of arcmin and a sensitivity
of per pixel. The resulting image is dominated by hot and cold
spots with rms fluctuations and typical size of . The
detailed angular power spectrum of the image features three peaks and two dips
at and , respectively. Such very characteristic
spectrum can be explained assuming that the detected structures are the result
of acoustic oscillations in the primeval plasma. In this framework, the
measured pattern constrains the density parameter to be (95% confidence interval). Other cosmological parameters, like the
spectral index of initial density fluctuations, the density parameter for
baryons, dark matter and dark energy, are detected or constrained by the
BOOMERanG measurements and by other recent CMB anisotropy experiments. When
combined with other cosmological observations, these results depict a new,
consistent, cosmological scenario.Comment: Proc. of the Erice School on "Neutrinos in Astro, Particle and
Nuclear Physics", 18.-26. September 2001, Amand Faessler, Jan Kuckei eds,
"Progress in Particle and Nuclear Physics", vol. 4
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