Erratum for the Report “A precise measurement of the magnetic field in the corona of the black hole binary V404 Cygni”

In the Report “A precise measurement of the magnetic field in the corona of the black hole binary V404 Cygni,” a calculation error led to values of the magnetic field that were about 14 times too high. The mathematical expressions given in the Report were correct, but the code used to calculate the numerical values included an extraneous factor, which led to incorrect results. The magnetic fields calculated from the observations at different wavelengths were all scaled by the same factor, so after this is removed they remain consistent with each other. The corrected value of the magnetic field is lower than previously calculated, making the field in V404 Cygni even more unlike those estimated for other systems. However, the lower magnetic field is no longer consistent with the value predicted from the equipartition model. The text, materials and methods, Table S1, and Figure S3 have been updated to reflect the corrected magnetic field values and to state that the system was not in equipartition. No other results or conclusions of the study were affected. The authors thank J. Malzac (Institut de Recherche en Astrophysique et Planétologie, Université de Toulouse) for alerting them to this error

Sediment trap efficiency of paddy fields at the watershed scale in a mountainous catchment in northwest Vietnam

Composite agricultural systems with permanent maize cultivation in the uplands and irrigated rice in the valleys are very common in mountainous southeast Asia. The soil loss and fertility decline of the upland fields is well documented, but little is known about reallocation of these sediments within the landscape. In this study, a turbidity-based linear mixed model was used to quantify sediment inputs, from surface reservoir irrigation water and from direct overland flow, into a paddy area of 13 ha. Simultaneously, the sediment load exported from the rice fields was determined. Mid-infrared spectroscopy was applied to analyze sediment particle size. Our results showed that per year, 64Mgha-1 of sediments were imported into paddy fields, of which around 75% were delivered by irrigation water and the remainder by direct overland flow during rainfall events. Overland flow contributed one-third of the received sandy fraction, while irrigated sediments were predominantly silty. Overall, rice fields were a net sink for sediments, trapping 28Mgha-1 a-1 or almost half of total sediment inputs. As paddy outflow consisted almost exclusively of silt- and clay-sized material, 24Mgha-1 a-1 of the trapped amount of sediment was estimated to be sandy. Under continued intensive upland maize cultivation, such a sustained input of coarse material could jeopardize paddy soil fertility, puddling capacity and ultimately food security of the inhabitants of these mountainous areas. Preventing direct overland flow from entering the paddy fields, however, could reduce sand inputs by up to 34 %

Quantifying uncertainty on sediment loads using bootstrap confidence intervals

Load estimates are more informative than constituent concentrations alone, as they allow quantification of on- and off-site impacts of environmental processes concerning pollutants, nutrients and sediment, such as soil fertility loss, reservoir sedimentation and irrigation channel siltation. While statistical models used to predict constituent concentrations have been developed considerably over the last few years, measures of uncertainty on constituent loads are rarely reported. Loads are the product of two predictions, constituent concentration and discharge, integrated over a time period, which does not make it straightforward to produce a standard error or a confidence interval. In this paper, a linear mixed model is used to estimate sediment concentrations. A bootstrap method is then developed that accounts for the uncertainty in the concentration and discharge predictions, allowing temporal correlation in the constituent data, and can be used when data transformations are required. The method was tested for a small watershed in Northwest Vietnam for the period 2010–2011. The results showed that confidence intervals were asymmetric, with the highest uncertainty in the upper limit, and that a load of 6262 Mg year-1 had a 95 % confidence interval of (4331, 12 267) in 2010 and a load of 5543 Mg an interval of (3593, 8975) in 2011. Additionally, the approach demonstrated that direct estimates from the data were biased downwards compared to bootstrap median estimates. These results imply that constituent loads predicted from regression-type water quality models could frequently be underestimating sediment yields and their environmental impact

Sediment-associated organic carbon and nitrogen inputs from erosion and irrigation to rice fields in a mountainous watershed in Northwest Vietnam

Maintaining indigenous nutrient supply and positive nutrient balances are key factors in sustaining rice yields. Irrigation systems act as conveyers for water, sediments and nutrients throughout landscapes, especially in mountainous, cultivated tropical areas where erosivity is usually high. Contributions of erosion and irrigation to the nutrient balance of paddy fields, however, are rarely assessed. In this study, a turbidity-based method was used to quantify sediment-associated organic carbon and nitrogen as well as dissolved nitrogen inputs from erosion and irrigation to a 13 ha rice area in Northwest Vietnam. The irrigation source is a surface reservoir, and both reservoir and irrigation channel are surrounded by permanent upland maize cultivation on the steep slopes. Additionally, organic carbon and nitrogen loads in paddy outflow were determined to obtain nutrient budgets. Irrigation contributed 90 % of sediment-associated organic carbon inputs and virtually all nitrogen inputs. Analysis of ammonium and nitrate in total nitrogen loads showed that 24 % of the total N inputs from irrigation to the rice area, or 0.28 Mg ha-1 a-1, were plant-available. Loads measured at the outlet of rice fields showed that paddies were a trap for sediment-associated nutrients: balancing inputs and outflow, a net load of 1.09 Mg ha-1 a-1 of sediment-associated organic carbon and 0.68 Mg ha-1 a-1 of sediment-associated nitrogen remained in the rice fields. Sediment-associated organic carbon and nitrogen inputs thus form an important contribution to the indigenous nutrient supply of rice in these maize-paddy systems, while the rice fields simultaneously capture nutrients, protecting downstream areas from the effects of land use intensification on surrounding slopes. These results underscore the importance of upland-lowland linkages in tropical, mountainous, erosion-prone areas

Flagellin delays spontaneous human neutrophil apoptosis

Neutrophils are short-lived cells that rapidly undergo apoptosis. However, their survival can be regulated by signals from the environment. Flagellin, the primary component of the bacterial flagella, is known to induce neutrophil activation. In this study we examined the ability of flagellin to modulate neutrophil apoptosis. Neutrophils cultured for 12 and 24 h in the presence of flagellin from Salmonella thyphimurim at concentrations found in pathological situations underwent a marked prevention of apoptosis. In contrast, Helicobacter pylori flagellin did not affect neutrophil survival, suggesting that Salmonella flagellin exerts the antiapoptotic effect by interacting with TLR5. The delaying in apoptosis mediated by Salmonella flagellin was coupled to higher expression levels of the antiapoptotic protein Mcl-1 and lower levels of activated caspase-3. Analysis of the signaling pathways indicated that Salmonella flagellin induced the activation of the p38 and ERK1/2 MAPK pathways as well as the PI3K/Akt pathway. Furthermore, it also stimulated IBα degradation and the phosphorylation of the p65 subunit, suggesting that Salmonella flagellin also triggers NF-B activation. Moreover, the pharmacological inhibition of ERK1/2 pathway and NF-B activation partially prevented the antiapoptotic effects exerted by flagellin. Finally, the apoptotic delaying effect exerted by flagellin was also evidenced when neutrophils were cultured with whole heat-killed S. thyphimurim. Both a wild-type and an aflagellate mutant S. thyphimurim strain promoted neutrophil survival; however, when cultured in low bacteria/neutrophil ratios, the flagellate bacteria showed a higher capacity to inhibit neutrophil apoptosis, although both strains showed a similar ability to induce neutrophil activation. Taken together, our results indicate that flagellin delays neutrophil apoptosis by a mechanism partially dependent on the activation of ERK1/2 MAPK and NF-B. The ability of flagellin to delay neutrophil apoptosis could contribute to perpetuate the inflammation during infections with flagellated bacteria. © 2010 USCAP, Inc All rights reserved.Fil:Salamone, G.V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Gabelloni, M.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Vermeulen, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Trevani, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina

The intensive care delirium research agenda:a multinational, interprofessional perspective

Delirium, a prevalent organ dysfunction in critically ill patients, is independently associated with increased morbidity. This last decade has witnessed an exponential growth in delirium research in hospitalized patients, including those critically ill, and this research has highlighted that delirium needs to be better understood mechanistically to help foster research that will ultimately lead to its prevention and treatment. In this invited, evidence-based paper, a multinational and interprofessional group of clinicians and researchers from within the fields of critical care medicine, psychiatry, pediatrics, anesthesiology, geriatrics, surgery, neurology, nursing, pharmacy, and the neurosciences sought to address five questions: (1) What is the current standard of care in managing ICU delirium? (2) What have been the major recent advances in delirium research and care? (3) What are the common delirium beliefs that have been challenged by recent trials? (4) What are the remaining areas of uncertainty in delirium research? (5) What are some of the top study areas/trials to be done in the next 10 years? Herein, we briefly review the epidemiology of delirium, the current best practices for management of critically ill patients at risk for delirium or experiencing delirium, identify recent advances in our understanding of delirium as well as gaps in knowledge, and discuss research opportunities and barriers to implementation, with the goal of promoting an integrated research agenda