Smart load cells: an industrial application

This paper presents a data acquisition solution using a RISC type microcontroller with a very few components around, taking advantage of the ratiometric functioning of the load cells. The need of thermally stable circuits is minimized through the use of the same amplification chain for both signal and reference. The amplification and filtering are done trough switched-capacitor techniques controlled by the microcontroller. This option allows the choice of the proper scale according to the platform and permits the auto-calibration of the system. The weighing tests show errors below 100 gr in 400 kg for an industrial platform of 8 smart load cells. The paper also describes an example of software calibration of a multi-load cell weigh-bridge using one processor per smart load cell

Microlenses array made with AZ4562 photoresist for stereoscopic acquisition

In this paper is presented a fabrication process for obtaining refractive microlenses arrays with high reproducibility and low cost. This process was specifically optimized for the AZ4562 photoresist. Functional prototypes of microlenses arrays with dimensions in the range of 30 m, 4.9 mm and 5 m for width, length and thickness, respectively, were fabricated and tested. The pre-thermal reflow spacing between adjacent isosceles trapezoids is 1.35-5.43 m, from bottom to top, respectively. This separation allows the photoresist to reflow and join the adjacent microlens creating a consistent and homogeneous array.This work and Rui Pedro Rocha are fully supported by the Portuguese Foundation for Science and Technology under the project FCT/PTDC/EEA-ELC/109936/2009 and the financial grant SFRH/BD/33733/2009, respectively. The authors would also like to acknowledge Dr.-Ing Christian Koch from MicroChemicals GmbH for the technical support

Theoretical study of electric field-dependent polaron-type mobility in conjugated polymers

We have used a self-consistent quantum molecular dynamics approach to calculate the mobility of both positive and negative polaron-type carriers on solated chains of poly(p-phenylene vinylene) (PPV) and some of its derivatives and the dependence of their mobility on the applied electric field. Our results suggest that polaron-type mobility along most of these polymer chains has a clear dependence on the electric field which is quite different from the result derived for bulk PPV-based materials.Fundação para a Ciência e a Tecnologia (FCT) Programa Operacional “Ciência , Tecnologia, Inovação” – POCTI/CTM/41574/2001, CONC-REEQ/443/EEI/2001 e SFRH/BD/11231/200

Design, fabrication and measurements with a UV Linear-Variable Optical Filter microspectrometer

An IC-Compatible Linear-Variable Optical Filter (LVOF) for application in the UV spectral range between 310 nm and 400 nm has been fabricated using resist reflow and an optimized dry-etching. The LVOF is mounted on the top of a commercially available CMOS camera to result in a UV microspectrometer. A special calibration technique has been employed that is based on an initial spectral measurement on a Xenon lamp. The image recorded on the camera during calibration is used in a signal processing algorithm to reconstruct the spectrum of the Mercury lamp and the calibration data is subsequently used in UV spectral measurements. Experiments on fabricated LVOF-based microspectrometer with this calibration approach implemented reveal a spectral resolution of 0.5 nm

An array of fabry-perot optical-channels for biological fluids analysis

This paper describes a biosystem (biological system) used to measure the concentration of biochemical substances in urine, serum, plasma or cerebrospinal fluid. Rather than just one channel, it comprises 16 optical-channels that enable the measurement of the concentration of 16 different biochemical substances. An array of 16 optical filters based on Fabry-Perot thin-films optical resonators has been designed. Each optical-channel is sensitive in a single wavelength with a full-width-half-maximum (FWHM) of 7 nm. The filter fabrication requires only four masks, used with different etch time. A commercially available band-pass optical filter with a band-pass wavelength in 450–650 nm is used. The biosystem requires only a white light source for illumination due the use of selective optical filters.Fundação para a Ciência e a Tecnologia (FCT) - SFRH/BD/1281/2000, POCTI/33747/ESE/1999 – Fundo Europeu para o Desenvolvimento Regional

Biological microsystem for measuring uric acid in biological fluids

This paper describes a biological microsystem (bio-system) for measuring uric acid concentration in serum, plasma or urine. Its operation is based on optical absorption in a well-defined part of the visible spectrum. The bio-system is composed by two dies: one is fabricated in polystyrene and contains the microchannels and the other is fabricated in a CMOS standard process and contains the photodetector and readout electronics. The uric acid concentration is measured by using a mixture of 14µl of infinity™ uric acid reagent with 0.25µl of sample. The achieved sensitivity is 0.33 mg/dl (±0.6% of the value in urine of a healthy person), with a 1mm lightpath. Using an optical absorption method, a maximum peak at wavelength λ = 494 nm, is detected. This bio-system can be included in the group of low-cost disposable devices for biological fluids analysis.Fundação para a Ciência e a Tecnologia (FCT) - SFRH/BD/1281/2000, POCTI/33747/ESE/1999), FEDER

A wireless RF CMOS mixed-signal interface for soil moisture measurements

This paper describes a wireless RF CMOS interface for soil moisture measurements. The interface basically comprises a Delta-Sigma (ΔΣ) modulator for acquiring an external sensor signal, and a RF section where data is transmitted to a local processing unit. The ΔΣ modulator is a single-bit, second-order modulator and it is implemented using switched-capacitors techniques in a fully-differential topology. With a sampling frequency of 423.75 kHz and an oversampling ratio (OSR) of 256, the modulator achieves a dynamic range of 98.7 dB (16.1 bit). The output of the modulator is applied to a counter, as a first-order decimation filter, and the result is stored. Prior to transmission, data is encoded as a pulse width modulated signal and assembled in a frame containing preamble and checksum control fields. This frame is then transmitted through a power amplifier operating at 433.92 MHz in class-E mode. To evaluate the ΔΣ modulator performance, the bitstream was acquired and transferred to a personal computer to perform digital filtering and decimation using MATLAB. The soil moisture sensor is based on dual-probe heat-pulse (DPHP) method and is implemented by using an integrated temperature sensor and a heater. After applying a heat-pulse for a fixed period of time, the temperature rise, that is a function of soil moisture, generates a differential voltage that is amplified and applied to the mixed-signal interface input. The described interface can also be used with other kinds of environmental sensors in a wireless sensors network. The CMOS mixed-signal interface has been implemented in a single-chip using a standard CMOS 0.7 μm process (AMI C07M-A, n-well, 2 metals and 1 poly)

CMOS x-rays detector array based on scintillating light guides

This paper describes a pixel imaging array consisting in 400µm x 400µm photodiodes fabricated in CMOS technology. An array of scintillating CsI:Tl crystals is placed above the photodiodes. These crystals are encapsulated in aluminum walls, forming a light path that guides the visible light produced by the scintillating crystal into the photodiodes. In This way, the x-ray energy is first converted into visible light which is then detected by the photodiode at the end of each light guide. The scintillator is 800 µm thick, absorbing almost all 20keV x-ray photons. Usually, the spatial resolution of the scintillating x-ray detectors is identical to the scintillator thickness. By using the light guides, the scintillator thickness can be increased without decreasing the spatial resolution. The increase of the scintillator thickness is desirable in order to increase the x-rays absorption efficiency. Tests carried out on the system show very promising results near 20keV

Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers

Infection with helminth parasites remains a persistent public health problem in developing countries. Three of these pathogens, the liver flukes Clonorchis sinensis, Opisthorchis viverrini and the blood fluke Schistosoma haematobium, are of particular concern due to their classification as Group 1 carcinogens: infection with these worms is carcinogenic. Using liquid chromatography-mass spectrometry (LC-MS/MS) approaches, we identified steroid hormone like (e.g., oxysterol-like, catechol estrogen quinone-like, etc.) metabolites and related DNA-adducts, apparently of parasite origin, in developmental stages including eggs of S. haematobium, in urine of people with urogenital schistosomiasis, and in the adult stage of O. viverrini. Since these kinds of sterol derivatives are metabolized to active quinones that can modify DNA, which in other contexts can lead to breast and other cancers, helminth parasite associated sterols might induce tumor-like phenotypes in the target cells susceptible to helminth parasite associated cancers, i.e., urothelial cells of the bladder in the case of urogenital schistosomiasis and the bile duct epithelia or cholangiocytes, in the case of O. viverrini and C. sinensis. Indeed we postulate that helminth induced cancers originate from parasite estrogen-host epithelial/urothelial cell chromosomal DNA adducts, and here we review recent findings that support this conjecture.José M. Correia da Costa, Maria J. Gouveia, Mónica C. Botelho, Lúcio L. Santos, and Júlio H. Santos thank FCT for Pest- OE/AGR/UI0211/2011 and Strategic Project UI211-2011- 2013, Clínica Sagrada Esperança and Hospital Américo Boavida, Luanda, Angola. Nuno Vale thanks to Fundação para a Ciência e Tecnologia (FCT, Portugal) and FEDER (European Union) for funding through project grants CONCREEQ/275/QUI and PEstC/QUI/UI0081/2011. Nuno Vale also thanks FCT for Post-Doc grant SFRH/BPD/48345/2008. The research findings reviewed here were supported by award R01CA155297 (Paul J. Brindley, Gabriel Rinaldi, Banchob Sripa) from the National Cancer Institute, NIH and P50 P50AI098639 (Banchob Sripa, Paul J. Brindley) from the National Institute of Allergy and Infectious Diseases, NIH