A 3D Model of the 4GLS VUV-FEL Conceptual Design Including Improved Modelling of the Optical Cavity

The Conceptual Design Report for the 4th Generation Light Source (4GLS) at Daresbury Laboratory in the UK was published in Spring 2006. The proposal includes a low-Q cavity (also called a regenerative amplifier) FEL to generate variably-polarised, temporally-coherent radiation in the photon energy range 3-10eV. A new simulation code has been developed that incorporates the 3D FEL code Genesis 1.3 and which simulates in 3D the optical components and radiation propagation within the non-amplifying sections of an optical cavity*. This code is used to estimate the optimum low-Q cavity design and characterise the output from the 4GLS VUV-FEL

Vortex pinning in high-Tc materials via randomly oriented columnar defects, created by GeV proton-induced fission fragments

Extensive work has shown that irradiation with 0.8 GeV protons can produce randomly oriented columnar defects (CD's) in a large number of HTS materials, specifically those cuprates containing Hg, Tl, Pb, Bi, and similar heavy elements. Absorbing the incident proton causes the nucleus of these species to fission, and the recoiling fission fragments create amorphous tracks, i.e., CD's. The superconductive transition temperature Tc decreases linearly with proton fluence and we analyze how the rate depends on the family of superconductors. In a study of Tl-2212 materials, adding defects decreases the equilibrium magnetization Meq(H) significantly in magnitude and changes its field dependence; this result is modeled in terms of vortex pinning. Analysis of the irreversible magnetization and its time dependence shows marked increases in the persistent current density and effective pinning energy, and leads to an estimate for the elementary attempt time for vortex hopping, tau ~ 4x10^(-9) s.Comment: Submitted to Physica C; presentation at ISS-2001. PDF file only, 13 pp. tota

A Quantum Bousso Bound

The Bousso bound requires that one quarter the area of a closed codimension two spacelike surface exceeds the entropy flux across a certain lightsheet terminating on the surface. The bound can be violated by quantum effects such as Hawking radiation. It is proposed that at the quantum level the bound be modified by adding to the area the quantum entanglement entropy across the surface. The validity of this quantum Bousso bound is proven in a two-dimensional large N dilaton gravity theory.Comment: 17 page

Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies

<p><b>Background and Purpose:</b> Glycine Antagonist in Neuroprotection (GAIN) International and GAIN Americas trials were prospectively designed, randomized, placebo-controlled trials of gavestinel, a glycine-site antagonist and putative neuroprotectant drug administered within 6 hours of suspected ischemic or hemorrhagic stroke. Both trials reported that gavestinel was ineffective in ischemic stroke. This analysis reports the results in those with primary intracerebral hemorrhage.</p> <p><b>Methods:</b> The primary hypothesis was that gavestinel treatment did not alter outcome, measured at 3 months by the Barthel Index (BI), from acute intracerebral hemorrhage, based on pooled results from both trials. The BI scores were divided into 3 groups: 95 to 100 (independent), 60 to 90 (assisted independence), and 0 to 55 (dependent) or dead.</p> <p><b>Results:</b> In total, 3450 patients were randomized in GAIN International (N=1804) and GAIN Americas (N=1646). Of these, 571 were ultimately identified to have spontaneous intracerebral hematoma on baseline head computerized tomography scan. The difference in distribution of trichotomized BI scores at 3 months between gavestinel and placebo was not statistically significant (P=0.09). Serious adverse events were reported at similar rates in the 2 treatment groups.</p> <p><b>Conclusions:</b> These observations from the combined GAIN International and GAIN Americas trials suggest that gavestinel is not of substantial benefit or harm to patients with primary intracerebral hemorrhage. These findings are similar to results previously reported in patients with ischemic stroke.</p&gt

Treatment of hypertension following endotracheal intubation A study comparing the efficacy of labetalol, practolol and placebo

Labetalol, a new adrenergic receptor antagonist, has both a- and B-blocking properties. Intravenous labetalol (0,25 and 0,5 mg/kg), practolol (0,4 mg/kg) and saline (1 ml), injected prior to anaesthesia, were compared with respect to their effect on the haemodynamic consequences of direct laryngoscopy followed by the passage of an endotracheal tube. When compared with intravenous saline injection, both labetalol and practolol obtunded the tachycardia induced by endotracheal intubation. The higher dose of labetalol was more effective in reducing the hypertensive response than the lower dose of practolol. However, none of the regimens completely abolished the adverse haemodynamic consequences of laryngotracheal, manipulations

A Comparative Study on the Solution Techniques for Fiber Orientation in Two-Dimensional Converging and Diverging Flows

The two-dimensional steady flow of both infinite and finite aspect ratio (length to diameter ratio) fibers suspended in a Newtonian fluid is investigated numeri cally. Forty-five-degree convergent and divergent channel geometries are considered for the analysis. Due to symmetry, only half the channel geometry is considered and the ori entation field is assumed to be planar. The analysis is carried out for the creeping flows where the inertia terms are neglected. Numerical grid generation is used to generate the mesh, and the transformed governing equations in terms of the stream function are solved in the computational domain using a finite difference scheme. In this study, several solu tion strategies for solving the orientation field are investigated. The orientation of individ ual fibers are assumed to be governed by Jeffery's equation. The orientation field, which can be expressed in different forms (i.e., a unit vector, tensorial quantities, or an orienta tion distribution function), is specified by solving the orientation equations along particle paths. A tracing technique is implemented to obtain these particle paths for each grid point in the flow domain. The solution of the orientation field is obtained by using two basic techniques. First, a large number of fibers are considered, and by using analytical expres sions developed to describe the orientation state of one fiber, a statistical orientation distri bution function is generated. Second, tensorial quantities (both second- and fourth-order orientation tensors) are employed to solve for the orientation field. In order to overcome the closure problem occurring in the resulting orientation equations, quadratic approxima tions are used. Maximum orientation angles are reported from both the techniques, and their accuracies are investigated. The maximum orientation angles (i.e., preferred orienta tion) obtained from the second- and fourth-order tensorial solutions are observed to be identical. On the other hand, the degree of fiber alignments that are specified by the indi vidual tensor components differ considerably. Comparison of the solution techniques shows that the accuracy of the preferred angle obtained from statistical solution is depen dent on the number of fibers considered. In addition, the calculations for the finite fiber aspect ratio revealed some discrepancies between the statistical and tensorial results at the regions of rapid fiber tumbling.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Molecular scale contact line hydrodynamics of immiscible flows

From extensive molecular dynamics simulations on immiscible two-phase flows, we find the relative slipping between the fluids and the solid wall everywhere to follow the generalized Navier boundary condition, in which the amount of slipping is proportional to the sum of tangential viscous stress and the uncompensated Young stress. The latter arises from the deviation of the fluid-fluid interface from its static configuration. We give a continuum formulation of the immiscible flow hydrodynamics, comprising the generalized Navier boundary condition, the Navier-Stokes equation, and the Cahn-Hilliard interfacial free energy. Our hydrodynamic model yields interfacial and velocity profiles matching those from the molecular dynamics simulations at the molecular-scale vicinity of the contact line. In particular, the behavior at high capillary numbers, leading to the breakup of the fluid-fluid interface, is accurately predicted.Comment: 33 pages for text in preprint format, 10 pages for 10 figures with captions, content changed in this resubmissio

On-chip quantum interference between silicon photon-pair sources

Large-scale integrated quantum photonic technologies1, 2 will require on-chip integration of identical photon sources with reconfigurable waveguide circuits. Relatively complex quantum circuits have been demonstrated already1, 2, 3, 4, 5, 6, 7, but few studies acknowledge the pressing need to integrate photon sources and waveguide circuits together on-chip8, 9. A key step towards such large-scale quantum technologies is the integration of just two individual photon sources within a waveguide circuit, and the demonstration of high-visibility quantum interference between them. Here, we report a silicon-on-insulator device that combines two four-wave mixing sources in an interferometer with a reconfigurable phase shifter. We configured the device to create and manipulate two-colour (non-degenerate) or same-colour (degenerate) path-entangled or path-unentangled photon pairs. We observed up to 100.0 ± 0.4% visibility quantum interference on-chip, and up to 95 ± 4% off-chip. Our device removes the need for external photon sources, provides a path to increasing the complexity of quantum photonic circuits and is a first step towards fully integrated quantum technologies