11 research outputs found
Morsures par vipères européennes en France métropolitaine en 2017 : utilisation de deux antivenins
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men
Démarche de création d'une fonction biomédicale répondant aux besoins de qualité et de sûreté
Use of serial carcinoembryonic antigen assays in detecting relapses in breast cancer involving high risk of metastasis
First cryogenic tests on BINGO innovations
International audienceNeutrinoless double-beta decay () is a hypothetical rare nuclear transition. Its observation would provide an important insight about the nature of neutrinos (Dirac or Majorana particle) demonstrating that the lepton number is not conserved. BINGO (Bi-Isotope Next Generation Observatory) aims to set the technological grounds for future bolometric experiments. It is based on a dual heat-light readout, i.e. a main scintillating absorber embedding the double-beta decay isotope accompanied by a cryogenic light detector. BINGO will study two of the most promising isotopes: Mo embedded in LiMoO (LMO) crystals and Te embedded in TeO. BINGO technology will reduce dramatically the background in the region of interest, thus boosting the discovery sensitivity of . The proposed solutions will have a high impact on next-generation bolometric tonne-scale experiments, like CUPID. In this contribution, we present the results obtained during the first tests performed in the framework of BINGO R&D
First cryogenic tests on BINGO innovations
International audienceNeutrinoless double-beta decay () is a hypothetical rare nuclear transition. Its observation would provide an important insight about the nature of neutrinos (Dirac or Majorana particle) demonstrating that the lepton number is not conserved. BINGO (Bi-Isotope Next Generation Observatory) aims to set the technological grounds for future bolometric experiments. It is based on a dual heat-light readout, i.e. a main scintillating absorber embedding the double-beta decay isotope accompanied by a cryogenic light detector. BINGO will study two of the most promising isotopes: Mo embedded in LiMoO (LMO) crystals and Te embedded in TeO. BINGO technology will reduce dramatically the background in the region of interest, thus boosting the discovery sensitivity of . The proposed solutions will have a high impact on next-generation bolometric tonne-scale experiments, like CUPID. In this contribution, we present the results obtained during the first tests performed in the framework of BINGO R&D
Structure, microstructure and electrical properties of Cu2+ doped (K,Na,Li)(Nb,Ta,Sb)O3 piezoelectric ceramics
BINGO innovative assembly for background reduction in bolometric experiments
International audienceBINGO is a project aiming to set the grounds for large-scale bolometric neutrinoless double-beta-decay experiments capable of investigating the effective Majorana neutrino mass at a few meV level. It focuses on developing innovative technologies to achieve a very low background index, of the order of counts/(keV kg yr) in the region of interest. The BINGO demonstrator, called MINI-BINGO, will be composed of LiMoO and TeO crystals coupled to bolometric light detectors designed to investigate the promising double-beta-decay isotopes Mo and Te. This will allow us to reject a significant background in bolometers caused by surface contamination from -active radionuclides by means of light yield selection. In addition, BINGO introduces new methods to mitigate other sources of background, such as surface radioactive contamination, external radioactivity, and pile-up due to random coincidence of background events. This paper focuses on the description of an innovative assembly designed to reduce the passive materials in line of sight of the detectors, which is expected to be a dominant source of background in next-generation bolometric experiments. We present the performance of two prototype modules -- housing four LiMoO crystals in total -- operated in the Canfranc underground laboratory in Spain within a facility developed for the CROSS double-beta-decay experiment
BINGO innovative assembly for background reduction in bolometric experiments
International audienceBINGO is a project aiming to set the grounds for large-scale bolometric neutrinoless double-beta-decay experiments capable of investigating the effective Majorana neutrino mass at a few meV level. It focuses on developing innovative technologies to achieve a very low background index, of the order of counts/(keV kg yr) in the region of interest. The BINGO demonstrator, called MINI-BINGO, will be composed of LiMoO and TeO crystals coupled to bolometric light detectors designed to investigate the promising double-beta-decay isotopes Mo and Te. This will allow us to reject a significant background in bolometers caused by surface contamination from -active radionuclides by means of light yield selection. In addition, BINGO introduces new methods to mitigate other sources of background, such as surface radioactive contamination, external radioactivity, and pile-up due to random coincidence of background events. This paper focuses on the description of an innovative assembly designed to reduce the passive materials in line of sight of the detectors, which is expected to be a dominant source of background in next-generation bolometric experiments. We present the performance of two prototype modules -- housing four LiMoO crystals in total -- operated in the Canfranc underground laboratory in Spain within a facility developed for the CROSS double-beta-decay experiment