1,542 research outputs found
A Population-Based Study of the Risk of Diabetic Retinopathy in Patients With Type 1 Diabetes and Celiac Disease
Objective: Celiac disease (CD) is associated with type 1 diabetes (T1D). In the current study, we examined whether CD affects the risk of diabetic retinopathy (DRP) in patients with T1D.
Research design and methods: This was a population-based cohort study. Through the Swedish National Patient Register, we identified 41,566 patients diagnosed with diabetes in 1964–2009 and who were ≤30 years of age at diagnosis. CD was defined as having villous atrophy (Marsh stage 3) according to small intestinal biopsies performed between 1969 and 2008, with biopsy reports obtained from Sweden’s 28 pathology departments. During follow-up, 947 T1D patients had a diagnosis of CD. We used Cox regression analysis with CD as a time-dependent covariate to estimate adjusted hazard ratios (aHRs) for DRP in patients with T1D and CD and compared them with patients with T1D but no CD.
Results: Duration of CD correlated with the risk of DRP. When results were stratified by time since CD diagnosis, individuals with T1D and CD were at a lower risk of DRP in the first 5 years after CD diagnosis (aHR 0.57 [95% CI 0.36–0.91]), followed by a neutral risk in years 5 to <10 (1.03 [0.68–1.57]). With longer follow-up, coexisting CD was a risk factor for DRP (10 to <15 years of follow-up, aHR 2.83 [95% CI 1.95–4.11]; ≥15 years of follow-up, 3.01 [1.43–6.32]).
Conclusions: Having a diagnosis of CD for >10 years is a risk factor for the development of DRP in T1D. Long-standing CD in patients with T1D merits intense monitoring of DRP
Towards a New Standard Model for Black Hole Accretion
We briefly review recent developments in black hole accretion disk theory,
emphasizing the vital role played by magnetohydrodynamic (MHD) stresses in
transporting angular momentum. The apparent universality of accretion-related
outflow phenomena is a strong indicator that large-scale MHD torques facilitate
vertical transport of angular momentum. This leads to an enhanced overall rate
of angular momentum transport and allows accretion of matter to proceed at an
interesting rate. Furthermore, we argue that when vertical transport is
important, the radial structure of the accretion disk is modified at small
radii and this affects the disk emission spectrum. We present a simple model
demonstrating how energetic, magnetically-driven outflows modify the emergent
disk emission spectrum with respect to that predicted by standard accretion
disk theory. A comparison of the predicted spectra against observations of
quasar spectral energy distributions suggests that mass accretion rates
inferred using the standard disk model may severely underestimate their true
values.Comment: To appear in the Fifth Stromlo Symposium Proceedings special issue of
ApS
Generation of two-mode nonclassical states and a quantum phase gate operation in trapped ion cavity QED
We propose a scheme to generate nonclassical states of a quantum system,
which is composed of the one-dimensional trapped ion motion and a single cavity
field mode. We show that two-mode SU(2) Schr\"odinger-cat states, entangled
coherent states, two-mode squeezed vacuum states and their superposition can be
generated. If the vibration mode and the cavity mode are used to represent
separately a qubit, a quantum phase gate can be implemented.Comment: to appear in PR
Pure mathematics in Australia
I.D. Macdonald argued in this journal in 1968 that there was an inadequate number of mathematicians teaching in Australian universities who were qualified by international standards to conduct honours courses and supervise research students..
Generation of arbitrary two dimensional motional state of a trapped ion
We present a scheme to generate an arbitrary two-dimensional quantum state of
motion of a trapped ion. This proposal is based on a sequence of laser pulses,
which are tuned appropriately to control transitions on the sidebands of two
modes of vibration. Not more than laser pulses are needed to
generate a pure state with upper phonon number and in the and
direction respectively.Comment: to appear in PR
Online Makespan Minimization with Parallel Schedules
In online makespan minimization a sequence of jobs
has to be scheduled on identical parallel machines so as to minimize the
maximum completion time of any job. We investigate the problem with an
essentially new model of resource augmentation. Here, an online algorithm is
allowed to build several schedules in parallel while processing . At
the end of the scheduling process the best schedule is selected. This model can
be viewed as providing an online algorithm with extra space, which is invested
to maintain multiple solutions. The setting is of particular interest in
parallel processing environments where each processor can maintain a single or
a small set of solutions.
We develop a (4/3+\eps)-competitive algorithm, for any 0<\eps\leq 1, that
uses a number of 1/\eps^{O(\log (1/\eps))} schedules. We also give a
(1+\eps)-competitive algorithm, for any 0<\eps\leq 1, that builds a
polynomial number of (m/\eps)^{O(\log (1/\eps) / \eps)} schedules. This value
depends on but is independent of the input . The performance
guarantees are nearly best possible. We show that any algorithm that achieves a
competitiveness smaller than 4/3 must construct schedules. Our
algorithms make use of novel guessing schemes that (1) predict the optimum
makespan of a job sequence to within a factor of 1+\eps and (2)
guess the job processing times and their frequencies in . In (2) we
have to sparsify the universe of all guesses so as to reduce the number of
schedules to a constant.
The competitive ratios achieved using parallel schedules are considerably
smaller than those in the standard problem without resource augmentation
Homodyne Bell's inequalities for entangled mesoscopic superpositions
We present a scheme for demonstrating violation of Bell's inequalities using
a spin-1/2 system entangled with a pair of classically distinguishable wave
packets in a harmonic potential. In the optical domain, such wave packets can
be represented by coherent states of a single light mode. The proposed scheme
involves standard spin-1/2 projections and measurements of the position and the
momentum of the harmonic oscillator system, which for a light mode can be
realized by means of homodyne detection. We discuss effects of imperfections,
including non-unit efficiency of the homodyne detector, and point out a close
link between the visibility of interference and violation of Bell's
inequalities in the described scheme.Comment: 6 pages, 3 figures. Extended version, journal reference adde
Multipartite entangled states in coupled quantum dots and cavity-QED
We investigate the generation of multipartite entangled state in a system of
N quantum dots embedded in a microcavity and examine the emergence of genuine
multipartite entanglement by three different characterizations of entanglement.
At certain times of dynamical evolution one can generate multipartite entangled
coherent exciton states or multiqubit states by initially preparing the
cavity field in a superposition of coherent states or the Fock state with one
photon, respectively. Finally we study environmental effects on multipartite
entanglement generation and find that the decay rate for the entanglement is
proportional to the number of excitons.Comment: 9 pages, 4 figures, to appear in Phys. Rev.
Persistent mucosal damage and risk of epilepsy in people with celiac disease
BACKGROUND: Celiac disease (CD) is associated with an increased risk of developing epilepsy, a risk that persists after CD diagnosis. A significant proportion of CD patients have persistent villous atrophy (VA) on follow-up biopsy. This study's objective was to determine whether persistent VA on follow-up biopsy affects long-term epilepsy risk and epilepsy-related hospital emergency admissions. METHODS: Nationwide Cohort Study. We identified all people in Sweden with histological evidence of CD who underwent a follow-up small intestinal biopsy (1969-2008). We compared those with persistent VA to those who showed histological improvement, assessing the development of epilepsy and related emergency hospital admissions (defined according to relevant ICD codes in the Swedish Patient Register). Cox regression analysis was used to assess outcome measures. RESULTS: Of 7590 people with CD who had a follow-up biopsy, VA was present in 43%. The presence of persistent VA was significantly associated with a reduced risk of developing newly-diagnosed epilepsy (hazard ratio [HR] 0.61; 95% confidence interval [CI] 0.38-0.98). On stratified analysis this effect was primarily amongst males (HR 0.35; 95 CI 0.15-0.80). Among the 58 CD patients with a prior diagnosis of epilepsy, those with persistent VA were less likely to visit an emergency department with epilepsy (HR 0.37; 95%CI 0.09-1.09). CONCLUSIONS: In a population-based study of CD individuals, persisting VA on follow up biopsy was associated with reduced future risk of developing epilepsy but did not influence emergency epilepsy-related hospital admissions. Mechanisms as to why persistent VA confers this benefit requires further exploration
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