The case of tin-plating of surface mounted glass diodes

New product development is one of the most powerful but difficult activities in business. It is also a very important factor affecting final product quality. There are many techniques available for new product development. Experimental design is now regarded as one of the most significant techniques. In this article, we will discuss how to use the technique of experimental design in developing a new product - an extrusion press. In order to provide a better understanding of this specific process, a brief description of the extrusion press is presented. To ensure the successful development of the extrusion press, customer requirements and expectations were obtained by detailed market research. The critical and non-critical factors affecting the performance of the extrusion press were identified in preliminary experiments. Through conducting single factorial experiments, the critical factorial levels were determined. The relationships between the performance indexes of the extrusion press and the four critical factors were determined on the basis of multi-factorial experiments. The mathematical models for the performance of the extrusion press were established according to a central composite rotatable design. The best combination of the four critical factors and the optimum performance indexes were determined by optimum design. The results were verified by conducting a confirmatory experiment. Finally, a number of conclusions became evident.

Control charts for monitoring the mean of AR(1) data

New product development is one of the most powerful but difficult activities in business. It is also a very important factor affecting final product quality. There are many techniques available for new product development. Experimental design is now regarded as one of the most significant techniques. In this article, we will discuss how to use the technique of experimental design in developing a new product - an extrusion press. In order to provide a better understanding of this specific process, a brief description of the extrusion press is presented. To ensure the successful development of the extrusion press, customer requirements and expectations were obtained by detailed market research. The critical and non-critical factors affecting the performance of the extrusion press were identified in preliminary experiments. Through conducting single factorial experiments, the critical factorial levels were determined. The relationships between the performance indexes of the extrusion press and the four critical factors were determined on the basis of multi-factorial experiments. The mathematical models for the performance of the extrusion press were established according to a central composite rotatable design. The best combination of the four critical factors and the optimum performance indexes were determined by optimum design. The results were verified by conducting a confirmatory experiment. Finally, a number of conclusions became evident.

Improving College Access and Completion for Low-Income and First-Generation Students: The Role of College Access and Success Programs

Resequencing of Agaricus bisporus herbarium specimen 99817338

Genomic Treasure Troves: Complete Genome Sequencing of Herbarium and Insect Museum Specimens

Unlocking the vast genomic diversity stored in natural history collections would create unprecedented opportunities for genome-scale evolutionary, phylogenetic, domestication and population genomic studies. Many researchers have been discouraged from using historical specimens in molecular studies because of both generally limited success of DNA extraction and the challenges associated with PCR-amplifying highly degraded DNA. In today's next-generation sequencing (NGS) world, opportunities and prospects for historical DNA have changed dramatically, as most NGS methods are actually designed for taking short fragmented DNA molecules as templates. Here we show that using a standard multiplex and paired-end Illumina sequencing approach, genome-scale sequence data can be generated reliably from dry-preserved plant, fungal and insect specimens collected up to 115 years ago, and with minimal destructive sampling. Using a reference-based assembly approach, we were able to produce the entire nuclear genome of a 43-year-old Arabidopsis thaliana (Brassicaceae) herbarium specimen with high and uniform sequence coverage. Nuclear genome sequences of three fungal specimens of 22–82 years of age (Agaricus bisporus, Laccaria bicolor, Pleurotus ostreatus) were generated with 81.4–97.9% exome coverage. Complete organellar genome sequences were assembled for all specimens. Using de novo assembly we retrieved between 16.2–71.0% of coding sequence regions, and hence remain somewhat cautious about prospects for de novo genome assembly from historical specimens. Non-target sequence contaminations were observed in 2 of our insect museum specimens. We anticipate that future museum genomics projects will perhaps not generate entire genome sequences in all cases (our specimens contained relatively small and low-complexity genomes), but at least generating vital comparative genomic data for testing (phylo)genetic, demographic and genetic hypotheses, that become increasingly more horizontal. Furthermore, NGS of historical DNA enables recovering crucial genetic information from old type specimens that to date have remained mostly unutilized and, thus, opens up a new frontier for taxonomic research as well

Breeding synchrony in birds

Breeding synchrony in birds, large clusters of individuals that are in the same breeding stage at the same time, is a well-known phenomenon. Individuals birds are expected to adapt their breeding schedules to changing environmental conditions: they all should aim to raise their chicks when they have the highest chance of survival. This way birds living in the same place and having the same environmental conditions will develop the same breeding schedules. But sharing comparable environmental conditions is not the only reason why birds might develop equal breeding times. Recent studies have shown that birds adapt their breeding schedules to the breeding schedules of close living neighbors. And although this can create breeding times which deviate from the optimal response to environmental change in an individual birds’ perspective, it still may enhance their fitness. In this paper, I will discuss how breeding synchrony may enhance or reduce fitness in colonial birds and what selection pressures may have led to breeding synchrony.