339 research outputs found
Approximating multi-dimensional Hamiltonian flows by billiards
Consider a family of smooth potentials , which, in the limit
, become a singular hard-wall potential of a multi-dimensional
billiard. We define auxiliary billiard domains that asymptote, as
to the original billiard, and provide asymptotic expansion of
the smooth Hamiltonian solution in terms of these billiard approximations. The
asymptotic expansion includes error estimates in the norm and an
iteration scheme for improving this approximation. Applying this theory to
smooth potentials which limit to the multi-dimensional close to ellipsoidal
billiards, we predict when the separatrix splitting persists for various types
of potentials
Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε
IKKε and TBK1 are noncanonical IKK family members which regulate inflammatory signaling pathways and also play important roles in oncogenesis. However, few inhibitors of these kinases have been identified. While the substrate specificity of IKKε has recently been described, the substrate specificity of TBK1 is unknown, hindering the development of high-throughput screening technologies for inhibitor identification. Here, we describe the optimal substrate phosphorylation motif for TBK1, and show that it is identical to the phosphorylation motif previously described for IKKε. This information enabled the design of an optimal TBK1/IKKε substrate peptide amenable to high-throughput screening and we assayed a 6,006 compound library that included 4,727 kinase-focused compounds to discover in vitro inhibitors of TBK1 and IKKε. 227 compounds in this library inhibited TBK1 at a concentration of 10 μM, while 57 compounds inhibited IKKε. Together, these data describe a new high-throughput screening assay which will facilitate the discovery of small molecule TBK1/IKKε inhibitors possessing therapeutic potential for both inflammatory diseases and cancer
Adaptive optics in high-contrast imaging
The development of adaptive optics (AO) played a major role in modern
astronomy over the last three decades. By compensating for the atmospheric
turbulence, these systems enable to reach the diffraction limit on large
telescopes. In this review, we will focus on high contrast applications of
adaptive optics, namely, imaging the close vicinity of bright stellar objects
and revealing regions otherwise hidden within the turbulent halo of the
atmosphere to look for objects with a contrast ratio lower than 10^-4 with
respect to the central star. Such high-contrast AO-corrected observations have
led to fundamental results in our current understanding of planetary formation
and evolution as well as stellar evolution. AO systems equipped three
generations of instruments, from the first pioneering experiments in the
nineties, to the first wave of instruments on 8m-class telescopes in the years
2000, and finally to the extreme AO systems that have recently started
operations. Along with high-contrast techniques, AO enables to reveal the
circumstellar environment: massive protoplanetary disks featuring spiral arms,
gaps or other asymmetries hinting at on-going planet formation, young giant
planets shining in thermal emission, or tenuous debris disks and micron-sized
dust leftover from collisions in massive asteroid-belt analogs. After
introducing the science case and technical requirements, we will review the
architecture of standard and extreme AO systems, before presenting a few
selected science highlights obtained with recent AO instruments.Comment: 24 pages, 14 figure
Active Galaxies in the UV
In this article we present different aspects of AGN studies demonstrating the
importance of the UV spectral range. Most important diagnostic lines for
studying the general physical conditions as well as the metalicities in the
central broad line region in AGN are emitted in the UV. The UV/FUV continuum in
AGN excites not only the emission lines in the immediate surrounding but it is
responsible for the ionization of the intergalactic medium in the early stages
of the universe. Variability studies of the emission line profiles of AGN in
the UV give us information on the structure and kinematics of the immediate
surrounding of the central supermassive black hole as well as on its mass
itself.Comment: 29 pages, 13 figures, Ap&SS in pres
Hydrophobic and ionic-interactions in bulk and confined water with implications for collapse and folding of proteins
Water and water-mediated interactions determine thermodynamic and kinetics of
protein folding, protein aggregation and self-assembly in confined spaces. To
obtain insights into the role of water in the context of folding problems, we
describe computer simulations of a few related model systems. The dynamics of
collapse of eicosane shows that upon expulsion of water the linear hydrocarbon
chain adopts an ordered helical hairpin structure with 1.5 turns. The structure
of dimer of eicosane molecules has two well ordered helical hairpins that are
stacked perpendicular to each other. As a prelude to studying folding in
confined spaces we used simulations to understand changes in hydrophobic and
ionic interactions in nano droplets. Solvation of hydrophobic and charged
species change drastically in nano water droplets. Hydrophobic species are
localized at the boundary. The tendency of ions to be at the boundary where
water density is low increases as the charge density decreases. Interaction
between hydrophobic, polar, and charged residue are also profoundly altered in
confined spaces. Using the results of computer simulations and accounting for
loss of chain entropy upon confinement we argue and then demonstrate, using
simulations in explicit water, that ordered states of generic amphiphilic
peptide sequences should be stabilized in cylindrical nanopores
Supermassive Binaries and Extragalactic Jets
Some quasars show Doppler shifted broad emission line peaks. I give new
statistics of the occurrence of these peaks and show that, while the most
spectacular cases are in quasars with strong radio jets inclined to the line of
sight, they are also almost as common in radio-quiet quasars. Theories of the
origin of the peaks are reviewed and it is argued that the displaced peaks are
most likely produced by the supermassive binary model. The separations of the
peaks in the 3C 390.3-type objects are consistent with orientation-dependent
"unified models" of quasar activity. If the supermassive binary model is
correct, all members of "the jet set" (astrophysical objects showing jets)
could be binaries.Comment: 31 pages, PostScript, missing figure is in ApJ 464, L105 (see
http://www.aas.org/ApJ/v464n2/5736/5736.html
HI in the Outskirts of Nearby Galaxies
The HI in disk galaxies frequently extends beyond the optical image, and can
trace the dark matter there. I briefly highlight the history of high spatial
resolution HI imaging, the contribution it made to the dark matter problem, and
the current tension between several dynamical methods to break the disk-halo
degeneracy. I then turn to the flaring problem, which could in principle probe
the shape of the dark halo. Instead, however, a lot of attention is now devoted
to understanding the role of gas accretion via galactic fountains. The current
cold dark matter theory has problems on galactic scales, such as
the core-cusp problem, which can be addressed with HI observations of dwarf
galaxies. For a similar range in rotation velocities, galaxies of type Sd have
thin disks, while those of type Im are much thicker. After a few comments on
modified Newtonian dynamics and on irregular galaxies, I close with statistics
on the HI extent of galaxies.Comment: 38 pages, 17 figures, invited review, book chapter in "Outskirts of
Galaxies", Eds. J. H. Knapen, J. C. Lee and A. Gil de Paz, Astrophysics and
Space Science Library, Springer, in pres
'Education, education, education' : legal, moral and clinical
This article brings together Professor Donald Nicolson's intellectual interest in professional legal ethics and his long-standing involvement with law clinics both as an advisor at the University of Cape Town and Director of the University of Bristol Law Clinic and the University of Strathclyde Law Clinic. In this article he looks at how legal education may help start this process of character development, arguing that the best means is through student involvement in voluntary law clinics. And here he builds upon his recent article which argues for voluntary, community service oriented law clinics over those which emphasise the education of students
Prevalence of asthma in a Portuguese countryside town: repercussions on absenteeism and self-concept
Fitting the integrated Spectral Energy Distributions of Galaxies
Fitting the spectral energy distributions (SEDs) of galaxies is an almost
universally used technique that has matured significantly in the last decade.
Model predictions and fitting procedures have improved significantly over this
time, attempting to keep up with the vastly increased volume and quality of
available data. We review here the field of SED fitting, describing the
modelling of ultraviolet to infrared galaxy SEDs, the creation of
multiwavelength data sets, and the methods used to fit model SEDs to observed
galaxy data sets. We touch upon the achievements and challenges in the major
ingredients of SED fitting, with a special emphasis on describing the interplay
between the quality of the available data, the quality of the available models,
and the best fitting technique to use in order to obtain a realistic
measurement as well as realistic uncertainties. We conclude that SED fitting
can be used effectively to derive a range of physical properties of galaxies,
such as redshift, stellar masses, star formation rates, dust masses, and
metallicities, with care taken not to over-interpret the available data. Yet
there still exist many issues such as estimating the age of the oldest stars in
a galaxy, finer details ofdust properties and dust-star geometry, and the
influences of poorly understood, luminous stellar types and phases. The
challenge for the coming years will be to improve both the models and the
observational data sets to resolve these uncertainties. The present review will
be made available on an interactive, moderated web page (sedfitting.org), where
the community can access and change the text. The intention is to expand the
text and keep it up to date over the coming years.Comment: 54 pages, 26 figures, Accepted for publication in Astrophysics &
Space Scienc
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