Gastrointestinal symptoms in low-dose aspirin users: a comparison between plain and buffered aspirin

Contains fulltext : 127588.pdf (publisher's version ) (Open Access)BACKGROUND: Aspirin is associated with gastrointestinal side effects such as gastric ulcers, gastric bleeding and dyspepsia. High-dose effervescent calcium carbasalate (ECC), a buffered formulation of aspirin, is associated with reduced gastric toxicity compared with plain aspirin in healthy volunteers, but at lower cardiovascular doses no beneficial effects were observed. AIM: To compare the prevalence of self-reported gastrointestinal symptoms between low-dose plain aspirin and ECC. METHODS: A total of 51,869 questionnaires were sent to a representative sample of the Dutch adult general population in December 2008. Questions about demographics, gastrointestinal symptoms in general and specific symptoms, comorbidity, and medication use including bioequivalent doses of ECC (100 mg) and plain aspirin (80 mg) were stated. We investigated the prevalence of self-reported gastrointestinal symptoms on ECC compared with plain aspirin using univariate and multivariate logistic regression analyses. RESULTS: A total of 16,715 questionnaires (32 %) were returned and eligible for analysis. Of these, 911 (5 %) respondents reported the use of plain aspirin, 633 (4 %) ECC and 15,171 reported using neither form of aspirin (91 %). The prevalence of self-reported gastrointestinal symptoms in general was higher in respondents using ECC (27.5 %) compared with plain aspirin (26.3 %), but did not differ significantly with either univariate (OR 1.06, 95 %CI 0.84-1.33), or multivariate analysis (aOR 1.08, 95 %CI 0.83-1.41). Also, none of the specific types of symptoms differed between the two aspirin formulations. CONCLUSIONS: In this large cohort representative of the general Dutch population, low-dose ECC is not associated with a reduction in self-reported gastrointestinal symptoms compared with plain aspirin

[Reduced risk of complications associated with severe acute (necrotizing) pancreatitis by administration of antibiotics; results from a literature review]

Item does not contain fulltex

[Screening for colorectal cancer: definitely implement],Screening for colorectal cancer: definitely implement

Item does not contain fulltextAn individual's lifetime risk of developing colorectal cancer is estimated at 5%. Currently, screening the asymptomatic population is the only way to effectively reduce mortality. Colorectal cancer screening meets prospectively defined scientific criteria for screening and is more cost-effective than existing screening programmes for cancers of the cervix and breast. Therefore, screening for colorectal cancer should be implemented

Flexible sigmoidoscopy to prevent colorectal cancer.

Item does not contain fulltex

Bevolkingsonderzoek naar darmkanker

Contains fulltext : 88638.pdf (publisher's version ) (Open Access

Effects of oltipraz, alpha-tocopherol, beta-carotene and phenethylisothiocyanate on rat oesophageal, gastric, colonic and hepatic glutathione, glutathione S-transferase and peroxidase

Contains fulltext : 23799___.PDF (publisher's version ) (Open Access

Effects of somatostatin on human satiety

Contains fulltext : 21928___.PDF (publisher's version ) (Open Access

Inhibition of gastrin-stimulated gastric acid secretion by medium-chain triglycerides and long-chain triglycerides in healthy young men.

Contains fulltext : 24134___.PDF (publisher's version ) (Open Access

Eradication of Helicobacter pylori infection in patients with non-ulcer dyspepsia : Effects on basal and bombesin-stimulated serum gastrin and gastric acid secretion

Contains fulltext : 21971___.PDF (publisher's version ) (Open Access